Upper GI Pharm

Question 1

omeprazole: mechanism of action, use

Answer 1

proton pump inhibitor, irreversibly inhibits H+/K+ ATPase in stomach parietal cells; acid suppression

Question 2

cimetidine: mechanism of action, use

Answer 2

H2 blocker, reversible block of histamine H2-receptors –> decrease H+ secretion by parietal cells; acid suppression

Question 3

cimetidine: toxicity

Answer 3

potent inhibitor of of cytochrome P450

Question 4

drug of choice for Zollinger-Ellison syndrome

Answer 4

PPIs (i.e., omeprazole)

Question 5

scopolamine: mechanism of action, use

Answer 5

muscarinic antagonist; motion sickness

Question 6

dimenhydrinate: mechanism of action, use

Answer 6

H1 blocker, reversible inhibition of H1 histamine receptors; motion sickness

Question 7

ondansetron: mechanism of action, use

Answer 7

serotonin (5-HT3)-receptor antagonist, decreases vagal stimulation; chemo-induced emesis

Question 8

metoclopramide: mechanism of action, use

Answer 8

D2 receptor antagonist, prokinetic; diabetic gastroparesis

Question 9

dexamethasone: mechanism of action, use

Answer 9

glucocorticoid; adjunct in treatment of cancer-induced nausea (suppresses tumor inflammation)