Upper GI conditions Flashcards

1
Q

Causes of upper GI bleed

A

Ulcers
Mallory weiss tear
oesophageal varices
malignancy

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2
Q

Duodenal + gastric ulcer presentation

A

DU = worse at night, more common.
Worse 2-5hrs after meals, alleviated by eating
GU = epigastric pain, N+V, exacerbated by eating

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3
Q

Investigations for ?ulcers

A

Endoscopy (OGD) - biopsies sent for histology is diagnostic
CLO urease H pylori test (carbon 13 urea breath test)
Bloods

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4
Q

Management of ulcers

A

Medical management with PPIs for 6-8 weeks
H pylori eradication if positive = metronidazole + clarithromycin + PPI for 7 days
Surgery for perforation or Zollinger Ellison syndrome
Repeat endoscopy

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5
Q

Causes of peptic ulcers

A
H pylori
NSAIDs
Aspirin 
Alcohol
Steroids
Zollinger-Ellison syndrome -severe peptic ulcer disease, gastric acid hypersecretion + gastrinoma
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6
Q

Red flags for peptic ulcers

A
ALARMS
Anaemia
Lost weight
Anorexia
Recent rapid onset
Malaena
Swallowing difficulties
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7
Q

Indications for urgent upper GI endoscopy

A

New onset dysphagia >55 y/o with weight loss + abdo pain/ reflux/ dyspepsia
New onset dyspepsia not responding to PPI

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8
Q

Management of acute GI bleed

A

ABCDE
Transfusion with blood, platelets + clotting factors
Variceal bleeding = terlipressin, abx, TIPS
Endoscopy
Varcieal bleeding = endoscopic injection of N-butyl-2-cyanoacrylate
Non variceal bleedong = mechanical method, thermal coagulation or fibrin with adrenaline
High dose PPI therapy

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9
Q

What scores are used to assess upper GI bleeding?

A

Blatchford at first assessment

Rockall after endoscopy

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10
Q

GI bleeds in pts on NSAIDs, aspirin + clopidogrel

A

Continue low dose aspirin
Stop NSAIDs during acute phase
Discuss risk of clopidogrel

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11
Q

How are upper GI bleeds prevented in acutely unwell pts?

A

H2 antagonist or PPI therapy in pts admitted to critical care
Use oral form if possible

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12
Q

What is dyspepsia?

A

> 4 weeks of upper abdo pain/ discomfort, heartburn, reflux, N+V

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13
Q

Common causes of dyspepsia

A

GORD, peptic ulcers, functional dyspepsia

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14
Q

Initial management of dyspepsia

A

Advice on lifestyle
Managing stress, anxiety + depression
Reducing drugs that may cause dyspepsia

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15
Q

Management of persistent (>1 month) dyspepsia

A

PPI for 1 month of H pylori testing

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16
Q

What test should be used for H pylori?

A

Carbon 13 urea breath test or stool antigen test

17
Q

When should a pt with dyspepsia be referred for endoscopy?

A

Recurrent symptoms despite management

2nd line eradication of H pylori is unsuccessful

18
Q

What is proven GORD?

A

Oesophagitis (endoscopy determined) or endoscopy negative reflux disease

19
Q

RF for GORD

A

Obesity, trigger foods, smoking, alcohol, coffee, stress
CCB, anticholinergics, theophylline, benzos, nitrates
Pregnancy

20
Q

How common is Barrett’s oesophagus + oesophageal cancer?

A

10-15% of GORD get Barretts

1-10% of these develop adenocarcinoma

21
Q

Management of GORD

A

Lifestyle, sleeping with head of bed raised
Stopping NSAIDs
Full dose PPI for 4 weeks for GORD + 8 weeks for oesophagitis

22
Q

Management of refractory GORD

A

Further 4 weeks PPI

Or add H2 antagonist

23
Q

When should pts with GORD be referred for endoscopy

A

Refractory to treatment, or unexplained

Associated with RF for Barrett’s

24
Q

Complications of peptic ulcers

A

Hemorrhage, perforation, gastric outlet obstruction

25
Q

What is achalasia?

A

Progressive degeneration of ganglion cells in myenteric plexus in esophagus leading to failure of relaxation of esophageal sphincter + loss of peristalsis

26
Q

S+S achalasia

A

Dysphagia + regurg of bland undigested food

Chest pain, heartburn, difficulty burping

27
Q

How is the diagnosis of achalasia made?

A

Manometry - aperistalsis + incomplete LES relaxation
Barium swallow
Endoscopy to exclude malignancy

28
Q

Management of achalasia

A

Mechanical disruption of fibres (pneumatic dilation, myotomy) or reduction in LES pressure (injection of botox, oral nitrates)

29
Q

What are the 2 types of functional dyspepsia?

A

Epigastric pain syndrome
Post-prandial distress syndrome
Can overlap

30
Q

Causes of esophageal perforation

A

Iatrogenic (endoscopic, biopsy, intubation, operative)
Barogenic (trauma, forceful vomiting)
FB ingestion
Carcinoma

31
Q

What is a Mallory-weiss tear?

A

Non-transmural esophageal tear

Due to forceful emesis

32
Q

What is Boerhaeve’s syndrome?

A

Transmural oesophageal perforation

Due to forceful emesis

33
Q

Complications of duodenal ulcer

A

Perforation
Posterior penetration
Hemorrhage
Gastric outlet obstruction

34
Q

What is a kissing ulcer?

A

Combination of perforation + bleeding

35
Q

Signs of metastatic gastric carcinoma

A
Virchow’s node (left supraclavicular) 
Blumer’s shelf (mass in Pouch of Douglas)
Krukenberg tumor (mets to ovary) 
Sister Mary Joseph node (umbilical mets)
Irish’s node (left axillary node)