Unit One Exam Flashcards
Who submits the Animal Welfare Assurance of Compliance that the animal research program meets all relevant regulations and standards?
Institutional Official
T/F: The Registry is a mandatory program that documents
professional development.
False
Which is NOT a required skill for ALAT’s?
A: Feeding animals
B: Changing animal bedding
C: Determining the sex of animals
D: Diagnosing diseases in animals
D: Diagnosing diseases in animals.
Which of the following provides the most valuable information about the research animals’ health and environment?
A: Accurate, up-to-date records
B: A well-composed protocol
C: The laboratory animal science mission statement
D: Standard operating procedures
A: Accurate, up-to-date records.
What helps to ensure that the data collected are not influenced by factors related to animal management?
Consistency
Which of the following warm-blooded vertebrates are NOT regulated by the Animal Welfare Act?
A: Guinea pigs
B: Wild mice
C: Purpose-bred rats
D: Rabbits
C: Purpose-bred rats
What nonprofit organization accredits laboratory animal research programs?
AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care)
What guidelines must an animal facility follow when research animals are euthanized at the end of a study?
AVMA Guidelines for the Euthanasia of Animals
Beyond food, water, shelter, and healthcare requirements, to comply the Animal Welfare Act, what must be provided to dogs in a laboratory animal research facility?
Opportunities for exercise.
To whom is Animal Welfare Assurance of Compliance Statement submitted?
Office of Laboratory Animal Welfare (OLAW)
What are the 3 R’s?
Replacement, refinement, reduction
Who administers the Animal Welfare Regulations?
APHIS (Animal and Plant Health Inspection) of the USDA (United States Department of Agriculture)
How often must IACUC perform inspections of the facility?
Every 6 months
Who has the authority to sign the PHS Assurance?
The Institutional Official
Who reviews all animal use protocols at the institution before studies using animals can begin?
IACUC
How often does APHIS inspect the animal research facility?
At least once a year
Which regulations apply to animal and non-animal research and safety studies funded or reviewed by the Food and Drug Administration and the Environmental Protection Agency?
Good Laboratory Practices
What is the role of a Quality Assurance Unit?
To ensure compliance with the GLP’s (Good laboratory Practices)
Which type of SOP addresses procedures specific to each study?
Procedural
The appropriate use of analgesics in postsurgical animals applies to which principle of the 3 R’s?
Refinement
Records of USDA inspections are available to the public under a provision of which federal law?
Freedom of Information Act
Who develops the disaster plan?
Senior management and safety officials
______ involves the development of methods for uniquely recognizing humans based upon physical features?
Biometrics
Where should the contact list be posted?
In common areas that have heavy traffic.
Why is it especially important that a background check is done for potential new employees of an animal research facility?
To avoid hiring anyone opposed to the use of animals in research.
Which federal agency enforces the rules or standards related to workplace safety?
OSHA (Occupational Safety and Health Administration)
At what noise level is considered a hazard to your hearing?
85 Decibels
What does an eyewash station use to clean the eye?
Clean water under low pressure
What is radioactivity?
The loss of energy by the emission of particles
Which type of hazard causes musculoskeletal injuries?
Ergonomic
What is the term of a disease that can be transmitted between animals and humans?
Zoonosis
What provides information on the toxicity of chemicals?
SDS (Safety Data Sheet)
Whose standards specifically address the storage and handling of radioactive materials in the facility?
NRC (Nuclear Regulatory Commission)
Which aspect of the annual health screen is especially important for animal care staff working with primates?
Tuberculin skin test
What type of injury can be prevented by taking frequent short breaks to rest and stretch the body?
Repetitive motion
What are three of the most common types of cage washers used in today’s facilities?
Tunnel washer, rack washer, cabinet washer
Which of the following is NOT a method used to test for residual microorganisms following decontamination?
A: Inoculating RODAC plates
B PCR testing of plenum and air filter dust
C: ATP measurement swabs
D: Spore strips
D Spore strips
List two reasons that automatic watering systems are often used to provide drinking water for laboratory animals.
They reduce the incidence of ergonomic injuries.
They eliminate labor in washing and sterilizing water bottles,
They provide a filtration system for the water.
What features of a biological safety cabinet protect the animal inside.
The HEPA filtration system.
High Efficiency Particulate Air
How is waste from tissue digesters disposed of?
Flushing down a sanitary sewer
What precautions must be taken when autoclaving a liquid substance in a bottle?
Liquid containers should not be tightly sealed or completely filled because the liquid will expand as the temperature rises.
What three characteristics determine the required time, pressure, and temperature of an autoclave?
The type, size and contamination level of the material being sterilized.
List the three methods that are used to check the effectiveness of an autoclave cycle, and give an example of each:
Mechanical: Pressure gauges
Chemical: Autoclave tape
Biological: Spore strips
Sterilizes instruments, equipment, and glass items using superheated steam and pressure
Autoclave
Buns material such as animal tissues and trash
Incinerator
Uses a sliding beam and weighing platform to determine weights
Balance
Protects the user from exposure to pathogenic microorganisms
Class III BSC (Bio-safety Cabinet)
Protects the user from chemical fumes
Fume hood
What two features of a cage dumping station help protect the technician during cage changing?
The air-circulating fan
The HEPA filter
What chemicals are often added to animals’ drinking water to reduce bacterial contamination?
Acid and chlorine
What type of cage washer is best used for cleaning larger pieces of equipment such as bulk carts and cage racks?
Rack washer
What is super heated steam?
Steam that is maintained at a greater temperature than 212 degrees F. because it is maintained at a higher pressure.
What type of micro-isolation cage is not mechanically ventilated? How is this type of cage venilated?
Static Micro-isolation cage: It has a filtered lid that allows passive air exchange into and out of the cage.
Why is feed offered in more than one location for group-housed animals?
Because dominant animals may hoard feed.
What health problem in guinea pigs can be caused by wire mesh flooring?
Pododermatitis
List the two species the most commonly found in aquatic cages in the laboratory setting
African clawed Frog
Zebra fish
Four types of plastics used to manufacture small animal caging systems, and withstand frequent autoclaving.
Polyethylene
Polycarbonate
Polysulfone
Polyphenylsulfone
What scenario would a disposable cage not be preferable?
For studies involving nonhuman primates
What are the five parameters that determine the necessary size of a primary enclosure?
Weight, vertical height and length of animal, enrichment needs, experimental requirements, exercise requirements
Metabolism cages are most commonly used with which of the following types of animals:
A: Ruminants
B: Rodents
C: Swine
D: Amphibians
B: Rodents
What are the two types of research studies that use biocontainment caging systems for the animals?
Infectious
Toxicity
If animals are infected with pathogens that are regulated by the CDC or the USDA, what special feature must their cages have?
A locking mechanism
What type of caging is not recommended by the Guide for rats and mice?
Wire bottom cages
Squeeze cages are typically used to hold what type of species of animals?
Nonhuman primates
Nestling materials, toys, foraging devices, and food treats are examples of which type of enrichment?
Environmental enrichment
Suspended caging systems are commonly used for which species?
Rabbits
What type of caging is the term “jump box” used to describe?
Transfer cage
