Unit One Exam Flashcards

1
Q

Who submits the Animal Welfare Assurance of Compliance that the animal research program meets all relevant regulations and standards?

A

Institutional Official

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2
Q

T/F: The Registry is a mandatory program that documents

professional development.

A

False

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3
Q

Which is NOT a required skill for ALAT’s?

A: Feeding animals
B: Changing animal bedding
C: Determining the sex of animals
D: Diagnosing diseases in animals

A

D: Diagnosing diseases in animals.

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4
Q

Which of the following provides the most valuable information about the research animals’ health and environment?

A: Accurate, up-to-date records
B: A well-composed protocol
C: The laboratory animal science mission statement
D: Standard operating procedures

A

A: Accurate, up-to-date records.

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5
Q

What helps to ensure that the data collected are not influenced by factors related to animal management?

A

Consistency

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6
Q

Which of the following warm-blooded vertebrates are NOT regulated by the Animal Welfare Act?

A: Guinea pigs
B: Wild mice
C: Purpose-bred rats
D: Rabbits

A

C: Purpose-bred rats

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7
Q

What nonprofit organization accredits laboratory animal research programs?

A

AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care)

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8
Q

What guidelines must an animal facility follow when research animals are euthanized at the end of a study?

A

AVMA Guidelines for the Euthanasia of Animals

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9
Q

Beyond food, water, shelter, and healthcare requirements, to comply the Animal Welfare Act, what must be provided to dogs in a laboratory animal research facility?

A

Opportunities for exercise.

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10
Q

To whom is Animal Welfare Assurance of Compliance Statement submitted?

A

Office of Laboratory Animal Welfare (OLAW)

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11
Q

What are the 3 R’s?

A

Replacement, refinement, reduction

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12
Q

Who administers the Animal Welfare Regulations?

A

APHIS (Animal and Plant Health Inspection) of the USDA (United States Department of Agriculture)

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13
Q

How often must IACUC perform inspections of the facility?

A

Every 6 months

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14
Q

Who has the authority to sign the PHS Assurance?

A

The Institutional Official

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15
Q

Who reviews all animal use protocols at the institution before studies using animals can begin?

A

IACUC

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16
Q

How often does APHIS inspect the animal research facility?

A

At least once a year

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17
Q

Which regulations apply to animal and non-animal research and safety studies funded or reviewed by the Food and Drug Administration and the Environmental Protection Agency?

A

Good Laboratory Practices

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18
Q

What is the role of a Quality Assurance Unit?

A

To ensure compliance with the GLP’s (Good laboratory Practices)

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19
Q

Which type of SOP addresses procedures specific to each study?

A

Procedural

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20
Q

The appropriate use of analgesics in postsurgical animals applies to which principle of the 3 R’s?

A

Refinement

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21
Q

Records of USDA inspections are available to the public under a provision of which federal law?

A

Freedom of Information Act

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22
Q

Who develops the disaster plan?

A

Senior management and safety officials

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23
Q

______ involves the development of methods for uniquely recognizing humans based upon physical features?

A

Biometrics

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24
Q

Where should the contact list be posted?

A

In common areas that have heavy traffic.

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25
Q

Why is it especially important that a background check is done for potential new employees of an animal research facility?

A

To avoid hiring anyone opposed to the use of animals in research.

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26
Q

Which federal agency enforces the rules or standards related to workplace safety?

A

OSHA (Occupational Safety and Health Administration)

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27
Q

At what noise level is considered a hazard to your hearing?

A

85 Decibels

28
Q

What does an eyewash station use to clean the eye?

A

Clean water under low pressure

29
Q

What is radioactivity?

A

The loss of energy by the emission of particles

30
Q

Which type of hazard causes musculoskeletal injuries?

A

Ergonomic

31
Q

What is the term of a disease that can be transmitted between animals and humans?

A

Zoonosis

32
Q

What provides information on the toxicity of chemicals?

A

SDS (Safety Data Sheet)

33
Q

Whose standards specifically address the storage and handling of radioactive materials in the facility?

A

NRC (Nuclear Regulatory Commission)

34
Q

Which aspect of the annual health screen is especially important for animal care staff working with primates?

A

Tuberculin skin test

35
Q

What type of injury can be prevented by taking frequent short breaks to rest and stretch the body?

A

Repetitive motion

36
Q

What are three of the most common types of cage washers used in today’s facilities?

A

Tunnel washer, rack washer, cabinet washer

37
Q

Which of the following is NOT a method used to test for residual microorganisms following decontamination?

A: Inoculating RODAC plates
B PCR testing of plenum and air filter dust
C: ATP measurement swabs
D: Spore strips

A

D Spore strips

38
Q

List two reasons that automatic watering systems are often used to provide drinking water for laboratory animals.

A

They reduce the incidence of ergonomic injuries.
They eliminate labor in washing and sterilizing water bottles,
They provide a filtration system for the water.

39
Q

What features of a biological safety cabinet protect the animal inside.

A

The HEPA filtration system.

High Efficiency Particulate Air

40
Q

How is waste from tissue digesters disposed of?

A

Flushing down a sanitary sewer

41
Q

What precautions must be taken when autoclaving a liquid substance in a bottle?

A

Liquid containers should not be tightly sealed or completely filled because the liquid will expand as the temperature rises.

42
Q

What three characteristics determine the required time, pressure, and temperature of an autoclave?

A

The type, size and contamination level of the material being sterilized.

43
Q

List the three methods that are used to check the effectiveness of an autoclave cycle, and give an example of each:

A

Mechanical: Pressure gauges
Chemical: Autoclave tape
Biological: Spore strips

44
Q

Sterilizes instruments, equipment, and glass items using superheated steam and pressure

A

Autoclave

45
Q

Buns material such as animal tissues and trash

A

Incinerator

46
Q

Uses a sliding beam and weighing platform to determine weights

A

Balance

47
Q

Protects the user from exposure to pathogenic microorganisms

A

Class III BSC (Bio-safety Cabinet)

48
Q

Protects the user from chemical fumes

A

Fume hood

49
Q

What two features of a cage dumping station help protect the technician during cage changing?

A

The air-circulating fan

The HEPA filter

50
Q

What chemicals are often added to animals’ drinking water to reduce bacterial contamination?

A

Acid and chlorine

51
Q

What type of cage washer is best used for cleaning larger pieces of equipment such as bulk carts and cage racks?

A

Rack washer

52
Q

What is super heated steam?

A

Steam that is maintained at a greater temperature than 212 degrees F. because it is maintained at a higher pressure.

53
Q

What type of micro-isolation cage is not mechanically ventilated? How is this type of cage venilated?

A

Static Micro-isolation cage: It has a filtered lid that allows passive air exchange into and out of the cage.

54
Q

Why is feed offered in more than one location for group-housed animals?

A

Because dominant animals may hoard feed.

55
Q

What health problem in guinea pigs can be caused by wire mesh flooring?

A

Pododermatitis

56
Q

List the two species the most commonly found in aquatic cages in the laboratory setting

A

African clawed Frog

Zebra fish

57
Q

Four types of plastics used to manufacture small animal caging systems, and withstand frequent autoclaving.

A

Polyethylene
Polycarbonate
Polysulfone
Polyphenylsulfone

58
Q

What scenario would a disposable cage not be preferable?

A

For studies involving nonhuman primates

59
Q

What are the five parameters that determine the necessary size of a primary enclosure?

A

Weight, vertical height and length of animal, enrichment needs, experimental requirements, exercise requirements

60
Q

Metabolism cages are most commonly used with which of the following types of animals:

A: Ruminants
B: Rodents
C: Swine
D: Amphibians

A

B: Rodents

61
Q

What are the two types of research studies that use biocontainment caging systems for the animals?

A

Infectious

Toxicity

62
Q

If animals are infected with pathogens that are regulated by the CDC or the USDA, what special feature must their cages have?

A

A locking mechanism

63
Q

What type of caging is not recommended by the Guide for rats and mice?

A

Wire bottom cages

64
Q

Squeeze cages are typically used to hold what type of species of animals?

A

Nonhuman primates

65
Q

Nestling materials, toys, foraging devices, and food treats are examples of which type of enrichment?

A

Environmental enrichment

66
Q

Suspended caging systems are commonly used for which species?

A

Rabbits

67
Q

What type of caging is the term “jump box” used to describe?

A

Transfer cage