Unit I Flashcards
Myology is the study of
muscles
Roughly what percentage is muscle of total body weight?
40-50%
The specific function of skeletal muscle is to
create voluntary movement
What are the 5 main functions of skeletal muscle in general though?
- movement
- stability
- communication
- control of body openings and passages
- heat production
What is the basic structural unit of a muscle?
the muscle fiber
What is a fasciculi?
groups of muscles fibers in a bundle
how are fasciculi and fibers bound together?
via connective tissue
Describe endomysium
inner most layer of connective tissue
it surrounds each muscle fiber and connects adjacent ones
Describe endomysium
middle layer of connective tissue
surrounds each fasciucli and compartmentalizes muscle
Describe epimysium
the outer most layer
surrounds entire muscle and separates it from surrounding organs
continuous with deep fascia and will become tendon
Describe the nuclei of muscle fibers
long and multinucleated and located around periphery of fiber
Explain hypertrophy
increase in size of muscle due to increase in size of each muscle fiber
Explain hyperplasia
increase of muscle size due to increase in number of muscle fibers.
What causes hyperplasia?
muscle is subjected to high resistance exercise inducing injury and followed by a regenerative process
What is the sarcoplasm of a muscle?
the cytoplasm.
Type I muscle fibers are best suited for what sorts of activities?
in where long sustained contraction is required, like endurance activites.
What type of metabolism are Type I fibers associated with?
aerobic metabolim
Type II muscle fibers are best suited what sort of activites?
quick powerful activities that require speed and strength.
What type of metabolism are Type II fibers associated with?
anaerobic metabolism
Between Type I and Type II which has more sarcoplasm and myoglobin?
Type I
Do Type I fibers have minimal capillary beds?
No they actually have extensive capillary beds
Is type I or type II fast twitch?
type II
Does Type II possess fatigue resistance?
not really. Type I is more suited for fatigue resistance
Between Type I and Type II which has the most mitochondria?
Type I
Do type I fibers have more glycogen/less fatty acids?
no, type II does. Type I has the opposite.
Which fiber type, I or II, atrophies with aging?
type II. Type I atrophies with immobilization
Describe intermediate fibers
they exhibit characteristics of having both type I and type II fibers
they contract faster than type I but slower than II
greater resistance to fatigue but histologically similar to type II
The sarcolema is the ______?
cell membrane
Define sarcoplasmic reticulum
tubular system which stores calcium and transports it to myofibrils
Define transverse tubules
tubular invaginations of the sarcolemma which pass nerve impulses to muscles and myofibrils
Define myoglobin
a red protein pigment in the sarcoplasm that stores oxygen in the muscles and has a higher affinity for oxygen than hemoglobin
Myofibrils are the__________
contractile apparatus of the muscle fibers
myofibrils are formed from
thick and thin fibers known as myofilaments
I-bands are described as
the dark areas
A bands are described as
the light areas
H bands are described as
the light areas in the middle of each dark band
M bands are described as
the think dark like in the middle H bands
Z lines are described as
the think dark lines in the middle of I bands
what is the smallest functional unit of the muscle and where does it start and end?
the sarcomere. it runs from z line to z line
Actin is found where and can be desribed as what?
its found in I bands and is thin
Mysoin is found where and can be described as what?
its found in A bands and is thick
Name the two regulatory proteins in muscles
troponin and tropomysoin
What allows troponin and tropomysoin to interact with their respective muscle proteins?
calcium
Describe how calcium allows the regulatory proteins to interact
it gets rid of the inhibition caused by the proteins which allows contraction
When a nerve impulse reaches the T-tubules where is calcium released from?
the sarcoplasmic reticulum
What is troponin located on?
actin
what happens to troponin once calcium reaches it?
calcium binds to it and causes a change in the shape of tropomysoin
what is tropomyosin located on?
mysoin
what does the change in shape of tropomyosin do?
it moves the molecule aside and exposes the myosin binding site on actin so the two proteins can interact and contract
Where does the aerobic pathway take place and what does it produce?
it takes place in the mitochondria and produces ATP
What does the aerobic pathway prefer to make ATP?
fatty acids from triglycerides
What form does excess ATP created take?
the form of heat
What substances does the anaerobic pathway depend on?
creatine phosphate and glycogen
which substances is used first in the anaerobic pathway?
creatine phosphate
what about the second substance used in anaerobic metabolism?
glycogen
what process is used to make ATP from glycogen?
glycolysis
Where in the body is glycogen stored?
muscle and liver cells
what is the by-product of glycolysis that is the cause of the pathway being so short?
lactic acid
From a metabolic POV of exercise describe phase one
within the first few minutes creatine phosphate and glycogen are the main fuel sources. up to 20% of stored muscle glycogen may be used during this time
From a metabolic POV of exercise describe phase two
metabolism shifts to the use of aerobic pathways and fatty acids to make ATP
From a metabolic POV of exercise describe phase three
as exercise intensifies metabolism shifts back to anaerobic pathways and uses up the remaining glycogen. its here the lactic acid builds up
Describe carbohydrate/glycogen loading
a diet trick that increases the store of glycogen in muscles
Describe Day one of carb loading
work to exhaustion to deplete glycogen stores
Describe day 2-4 of carb loading
continue exercise and eat meals high in fat and protein, and low in carbs
Describe day 5-7 of carb loading
no exercise and eat meals high in carbs
What is the theory behind carb loading?
its that the body thinks that there is a problem with glycogen storing and begins storing more glycogen than normal
What are some reported side effects of carb loading?
light headedness, impairment of mental acuity, and for every stored gram of glycogen 3 grams of water accompany it.
How many cups of coffee may help an endurance athlete in a competition?
about two cups an hour before their competition
What effect does the caffeine in the coffee have?
it may help burn fatty acids better and increase calcium permeability
How does the better burning of fatty acids from the use of caffeine have an impact?
it should delay the use of glycogen
What is limit set by the IOC for the use of caffeine?
1000mg
Describe induced erythrocythemia/blood doping
by increasing the amount of RBC’s one can increase their oxygen carrying capacity which can increase their endurancecpacity
What are some risks of blood doping?
rash, fever, acute hemolysis, transmission of viruses, and kidney damage due to fluid overload
What is erythropoietin and what is it used for?
its a natural hormone made by the kidneys that helps make RBC’s. but it can be synthesized to use for blood doping or for anemics
What is the main danger of erythropoietin?
it can thicken blood to lethal levels
What are anabolic steroids and their use?
a synthetic form of testosterone that attempts to utilize the anabolic effects with minimal androgenic effects
what does anabolic mean?
the stimulation of protein synthesis
what does androgenic mean?
development of secondary sexual characteristics
Describe the oil based form of steroids
an injection with fewer side effects but is detectable for several months in the body
Describe the water based form of steroids
pill form, has more side effects, and is cleared from the body in 3-4 weeks
What does the term stacking mean when referring to steroids?
taking several forms of steroids
What does pyramiding mean when using steroids?
begin using low doses then ascend to a peak and taper off
What is the typical time cycle of steroid use?
6-8 weeks
List some of the short term side effects of steroid use
headaches, back acne, testicle shrinkage, aggressiveness, gynecomastia, and tendon damage.
List some long term side effects of steroid use
cardiovascular issues, GI issues, the reproductive system, and endocrine system are affected
List short term side effects in women who use steroids
larger clitoris, smaller mammary glands, facial hair, deeper voice, tendon damage, and better androgenic effects
How do steroids physiologically work
they increase the amount of growth hormones, and activate protein synthesis, while inhibiting protein breakdown
What are some clinical reasons to prescribe steroids?
restore hormonal levels, improve mood, increase appetite, and body weight in terminally ill patients
What is the chemical composition of a muscle?
75% water, 20% protein, 5% others
Will a single muscle fiber contract by itself?
no, instead several fibers will contract at the same time
Describe a motor unit
a nerve fiber and the group of muscle fibers it supplies
What is the smallest part of muscle that can contract by itself?
the motor unit
What makes a contraction stronger?
the number of motor units being contracted at once
What makes a motor unit capable of precise control?
having a smaller amount of motor fibers
What portions does a neuromuscular junction possess?
presynaptic, postsynaptic, and synaptic cleft.
What is the presynaptic portion of a neuromuscluar junction?
the nerve ending
What is the postsynaptic portion a a neuromuscular junction?
the sarcolemma of a muscle fiber
what is the synaptic cleft of a neuromuscular junction?
the space between post and pre synaptic portions
Desribce how a nerve impulse makes it’s way across a neuromuscular junction
when a nerve impulse reaches the presynaptic portion acetylcholine is released and diffuses across the cleft to bind on to receptors of the postsynaptic portion.
Describe what happens once the nerve impulse has reached the postsynaptic portion
Once acetylcholine has binded, an action potential is sent down the T-tubules allow muscle proteins to contract.
What breaks down acetylcholine from the binding site?
acetylcholinesterease
What is myasthenia gravis?
a common autoimmune disorder in which the ACH receptor sites are destroyed by abnormal antibodies that leads to the atrophy of T-tubules
Is myasthenia gravis genetic?
no
What does myasthenia gravis affect first?
cranial nerves and progresses to the extremities
what gland is commonly affected by those who have myasthenia gravis?
the thymus gland is enlarged or tumorous
What is transitional neonatal myasthenia gravis?
a 25% chance of a mother passing abnormal antibodies to the fetus thru the placenta
What effect does nicotine have on ACH?
it binds to receptor sites instead of ACH, and because nicotine cant be degraded by ACHe it creates a more prolonged action potential
What effect does snake venom have?
it prevents ACH from from binding to receptors and prevents action potentials from occurring
what effect does organophosphate have?
it inactivates ACHe meaning ACH builds up at the postsynaptic portion causing muscles to stay contracted
What effect does botulin toxin have?
it blocks ACH from being released from the presynaptic portion