Unit 7 Flashcards

1
Q

What is the main function of neurones?

A

receive and process information from neurones and sensory receptors
send information to next neurone in chain of command or effector organs

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2
Q

What is the surface of dendrites lined with?

A

synaptic receptors
-> allow to receive stimulation

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3
Q

What are dendritic spines?

A

cover many dendrites
increase surface area

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4
Q

Are synapses also possible on surface of cell bodies?

A

yes
-> also covered in synaptic receptors

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5
Q

Axon

A

thin fibre of constant diameter
covered in myelin sheath
interruptions in myellin sheath
-> nodes of ranvier

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6
Q

How many axons do neurones have?

A

1
-> can have many branches

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7
Q

Presynaptic terminal

A

swelling at end of each axon
-> allows release of neurotransmitters into synapse

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8
Q

What does the surface of neurones consist of and what is its purpose?

A

cell membrane
-> impermeable
separates inside of cell from external environment

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9
Q

What is extermely important for creating a nerve impulse?

A

protein channels
-> allow controlled flow of important molecules (e.g. water, oxygen, etc.)

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10
Q

What type of transmission does our nervous system use to communicate information?

A

electrochemical transmission

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11
Q

How did the nervous system evolve to fix the issue of an electrical impulse losing strength over longer distances?

A

By regenerating the message at various points along the axon

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12
Q

How fast are impulses conducted?

A

1-100 m/s

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13
Q

What are Ions?

A

Two parts with exactly opposite charge
can be seen when electrolytes are dissolved in water

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14
Q

Which forces act on ions?

A

Electrostatic pressure
Diffusion

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15
Q

Electrostatic pressure

A

causes ions to move towards opposite electrical charge

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16
Q

What is electrical potential?

A

difference between areas of positivity and negativity

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17
Q

Diffusion

A

causes ions to move towards areas of relatively lower concentration

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18
Q

What is the difference in concentration of two ions refered to and what is the difference in electrical potential refered to?

A

concentration gradient
electrical gradient

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19
Q

What is membrane potential produced by and what is it?

A

forces of electrostatic pressure and diffusion
difference in electrical charge between inside and outside of cells

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20
Q

What is the membrane at rest and what does that mean?

A

polarised
electrical potential inside membrane being slightly negative

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21
Q

What is resting potential?

A

voltage between inside and outside of cells at rest
usually around 70 mV

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22
Q

Selective permeability

A

some molecules can pass through it freely
others need membrane channels

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23
Q

Concentration of ions at rest

A

more Na+ on outside and k+ inside the cells
inside more negative
Na+ wants to enter
-> wall impermeable to Na+
K+ at equilibrium
-> electrostatic pressure and diffusion equally at play

24
Q

How does a neurone deal with Na+ and K+ ions leaking every once in a while?

A

sodium-potassium pumps
3 Na+ out
2 K+ in

25
Q

How does the inside of the cell stay negative?

A

organic anions (A-)
unable to pass through cell membrane
Chloride ions (Cl-)
-> however mostly outside the cell body
-> again at equilibrium

26
Q

Why does the cell use so much energy at sodium-potassium pumps? (about 40%)

A

cells are always ready for action

27
Q

What happens when you apply a negative charge to the cell membrane?

A

hyperpolarisation

28
Q

What happens when you apply a positive charge to the cell membrane?

A

depolarisation

29
Q

What happens when the threshold of excitation is reached?

A

massive depolarisation
causes voltage-gated Na+ channels to open
-> rapid influx of Na+
potential shoots up further towards positivity
-> action potential

30
Q

All-or-none law

A

any depolarisation reaching threshold of excitation produces action potential

31
Q

What can vary between action potentials of neurones and what stays consistent?

A

strength and speed vary between neurones
stay the same for each neurone
-> neurones either fire, or don’t

32
Q

What happens at the end of the action potential?

A

membrane potential reversed (inside more positive than outside)
-> Na+ channels snap shut

33
Q

When do K+ channels open?

A

at slightly greater levels of depolarisation
-> a bit later than Na+ channels

34
Q

What else helps the neurone repolarise?

A

Cl- influx

35
Q

What is the process of returning to negativity known as?

A

repolarisation

36
Q

What produces hyperpolarisation?

A

K+ channels remain open for a while longer
-> more K+ leave cell to lower concentration
-> repolarisation continues past resting potential

37
Q

How is the resting potential finally restored?

A

closing of K+ channels
sodium-potassium pump ensures right concentration of Na+ and K+ on each side

38
Q

refractory period

A

time during which a neurone is unable or less likely to produce another action potential
initial part: absolute refractory period
-> impossible to produce another AP
second part: relative refractory period
-> neurones require larger than normal stimulation

39
Q

How does action potential move down the neurone?

A

moves from cell body to end of axon
Na+ flow inside axon to neighboring areas of negativity
-> causes neighboring area to become more positive and reach threshold of excitation
-> AP regenerated
=> proagation of AP
only in direction of axon terminal because of refractory period

40
Q

Can AP occur anywhere?

A

no, only at nodes of ranvier due to absence of NA+ channels in myelinated parts of axon

41
Q

Na+ diffuses towards next node of ranvier where AP is generated again.
How is this form of conduction called?

A

saltatory conduction

42
Q

Why is saltatory conduction efficient?

A

speeds up propagation of AP
-> don’t have to occur at every point along axon
maintains strength of impulse
-> because of periodical regeneration
conserves energy
-> less sodium-potassium pumps needed

43
Q

Multiple sclerosis

A

autoimmune disease
immune system attacks myelin sheath
most axon potentials die out between nodes of ranvier due to absence of Na+ channels in unmyelinated parts
Symptoms: visual impairments, poor muscle coordination, fatigue, etc.

44
Q

postsynaptic potential

A

change in membrane potential of postsynaptic neurone after receiving stimulation from presynaptic neurone

45
Q

Why is postsynaptic potential known as a type of graded potential?

A

stimulation of postsynaptic neurone doesnt always cause mebrane to reach threshold of excitation

46
Q

Action potentials along axon vs postsynaptic potentials

A

along axon: always depolarisations
postsynaptic: depolarisation (excitatory) or hyperpolarisations (inhibitory)

47
Q

Excitatory postsynaptic potential

A

EPSP
result of an influx of Na+ into postsynaptic membrane
quickly decays if threshold of excitation isnt reached

48
Q

What is temporal summation?

A

if time between multiple ESPS is short enough they add up
-> helps reach the threshold of excitation

49
Q

What is spatial summation?

A

Several presynaptic neurones stimultion postsynaptic neurone

50
Q

Inhibitory post-synaptic potential

A

IPSP
pushes postsynaptic potential further away from threshold of excitability
decreases likelihood of postsynaptic neurone firing

51
Q

What did Loewi find out and how?

A

most presynaptic neurones communicate messages via neurotransmitters
Stimulated vagus nerve in one frog
-> decreases heart rate
collected fluid and transferred it to second frog’s heart
-> heart rate also decreased

52
Q

Where are smaller and bigger neurotransmitters synthesised?

A

Smaller: axon terminal (e.g. monoamines)
larger: cell body and carried down (e.g. neuropeptides)

53
Q

The activation of which type of voltage-gated channels causes and influx leading to the release of neurotransmitters in the presynaptic terminal?

A

Ca2+ channels
influx of Ca2+

54
Q

What causes postsynaptic ion channels to open?

A

neurotransmitter diffusing to receptors

55
Q

What are the methods used to remove neurotransmitters from the synapse to prevent overstimulation?

A

Breaking them down
-> e.g. acetylcholine broken down by acetylcholinesterase into acetate and choline
-> choline re-synthesised in terminal
Reuptake: for other neurotransmitters like some monoamines, acheived by using transporter proteins
Diffusing away from synapse

56
Q

Negative feedback

A

used to limit release of neurotransmitters of presynaptic neurone
2 ways:
1) many have autoreceptors that detect release of neurotransmitters and inhibit further release
2) some postsynaptic neurones release chemicals (e.g. nitric oxide) to inhibit further release