Unit 6 Mechanism of Action

Question 1

Lisinopril

Answer 1

ACE inhibitors work by inhibiting angiotensin II
Blocks aldosterone
Promotes Potassium retention and excretion of water and sodium
Results in Vasodilation and lower blood pressure

Question 2

Valsartan

Answer 2

ARB’s prevent the release of aldosterone by blocking angiotensin II from receptors.

Question 3

Alpha Adrenergic Blockers

Prazosin

Answer 3

Block alpha-adrenergic receptors causing vasodilation resulting in decreased blood pressure.

Question 4

Thiazide Diuretics

Answer 4

Work by acting on the distal convoluted renal tube. They promote sodium, chloride and water excretion.

Question 5

Loop Diuretics

Answer 5

Works by acting on the look of Henle by inhibiting chloride transport of sodium and the passive reabsorption of sodium.
As more fluid is passed out by the kidneys, less fluid remains in the bloodstream.

Question 6

Potassium-Sparing

Answer 6

Works by blocking the action of aldosterone. Promotes sodium and water excretion and promotes potassium retention.

Question 7

Osmotic Diuretics

Answer 7

Works by increasing osmolality and sodium reabsorption in the proximal tubule, drawing in more water.
Kidneys excrete sodium, chloride, potassium and water.