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Pharm 6 > Unit 6 Drugs Random Order > Flashcards

Unit 6 Drugs Random Order Flashcards

1
Q

Saw Palmetto

A

Use: BPH

May be eff. but not as eff. as existing drugs (azosins”

Mech: Inh test synth (enz inh)+Inh test binding to receptor

SE:

  • Minimal SE
  • Drug interactions due to hormone effects
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2
Q

Aluminum hydroxide

Al(OH)3

A

Antacid

Speed-slow

Duration-long

Neutralizing-low

SE:

  • Constipation
  • Adsorbs drugs
  • Loss of phosphate
  • Al toxicity
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2
Q

Polyethylene glycol

A

GI Drug

Cathartic–Osmotic agent

DOC for colonoscopy

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3
Q

Castor oil

A

GI Drug

Cathartic–Gastric Irritants

Mech: Stimulate gastric nn

Increase motility

Decrease electrolyte secretion into gut

SE:

  • Nephritis
  • Liver damage
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3
Q

Linaclotide

A

GI Drug

Cathartic–Secretion enhancer

Mech: Activate guanylate cyclase

Increase Cl secretion in stomach

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3
Q

Garlic

A

Uses: Decrease blood lipids

May slightly lower blood lipids

1 fresh clove/day

SE:

  • Induce P450
  • Bad breath
  • Decrease clotting
  • Decrease conc. of some reverse transcriptase inh.
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4
Q

Mg(OH)2

A

GI Drug

Cathartic–Osmotic agent

AKA Milk of Magnesia

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4
Q

Codeine

A

Tx: Diarrhea

Narcotic agent

Mech: act a specific receptor

Not generally used for obvious reasons

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4
Q

Digoxin

A

Emetic–central stimulant

Mech: Stimulates DA sites in CTZ

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5
Q

Sucralfate

A

GI drug-Enhance mucosal defense

Aluminum salt

Tx: Ulcers

Mech: Complex that becomes viscous and binds to damaged mucosa when exposed to acid

SE:

  • Constipation
  • Excess Al absorption

Contraindication: H+ depleters (PPI or antacids)

SucrALfate=ALuminum salt→Excess Al

Sucralfate=sucrose=sticky…so this sticks to damaged mucosa

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6
Q

Immunosuppressants for IBS

A

Methotrexate

Cyclosporine

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7
Q

Miglitol

A

Tx: Diabetes

Glucose abs. delayers

Mech: Inh. alpha glucosidase

Prevents breakdown of complex carbs in gut

SE:

  • Unabsorbed carbs ferment in gut
    • Cramps
    • Diarrhea
    • Flatulence

Mig--litol

_Midg_ets (Mack) are little b/c they don’t absorb any carbs

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8
Q

Dronabinol

A

Anti-emetic–THC derivative

Mech: Bind cannabinoid receptor

SE: Increased appetite

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8
Q

Calcitonin

A

Tx: Ca disorders

Mech: Binds to and inh. osteoclasts

Effects opposite of PTH

Secreted by thyroid gland

1st line of defense for Paget’s disease

SE:

  • Increase risk of cancer
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9
Q

What are the short acting designer insulins?

A

Regular human insulin

Lispro

Aspart

Glulisine

2-5 hrs

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10
Q

Pramlintide

A

Tx: Diabetes

Amylin analogs

Mech: Activate amylin receptor→

Decrease gastric emptying

Decrease appetite

Route: SubQ before meals

SE:

  • Severe hypoglycemia
  • prAMLINtide=AMyLIN analog*
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11
Q

Scopolamine

A

Anti-emetic–anti-cholinergic

Mech: Block muscarinic receptor

Route: Patch

SE:

  • Dry
  • Drowsy
  • Etc.
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12
Q

What are the gastric irritants used as cathartics?

A

Cascara

Senna

Castor oil

Bisacodyl

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13
Q

Psyllium

A

GI Drug

Cathartic–Bulk adding agent

Mech: Like eating fiber

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14
Q

Yohimbe

A

Use: ED

Mech: Alpha 2 blocker in CNS

SE:

  • Hypertension
  • MAOI
  • CNS excitation
  • Tachycardia
  • Tremor
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14
Q

Ergocalciferol (D2)

A

Tx: Ca disorders

Mech: Vit D analog

Less potent than calcitriol

SE: Hypothyroidism

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15
Q

Tolbutamide

A

Tx: Diabetes

Oral hypoglycemic agents

First gen sulphonylureas

Mech: K channel blockers

Block K channels on B cells →Increase Ca→Insulin secretion

Duration: 6-12 hrs

Contra/Indications:

  • Do not use if you have renal or hepatic damage
  • Not overweight
  • Have some islet fxn

SE:

  • Hypoglycemia and hypoglycemia coma
    • More common in drugs w/ longer duration
  • Can be teratogenic
  • Can increase death due to cardiovascular problems
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16
Q

What are the stool softeners?

A

Dioctal sodium sulfosuccinate

Mineral oil

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16
Q

Alpha galactosidase

A

Tx: Diarrhea

Mech: Increase metab. of oligosacc.→digestible sugars

Oligosacc. produce gas

  • Alpha GAlactoSidase inh. GAS production*
  • *Be careful there are alpha-glucosidase inh in the diabetes section**
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18
Q

Misoprostole

A

GI drug-Enhance mucosal defense

Tx: Ulcers

Drop in PGs→Ulcer

Asprin (NSAIDs) and GCs can decrease PGs

Mech: Prostaglandin analog

SE:

  • Uterine contractility (abortifacient)
  • You eat miso soup when you have a stomach ache because it is prostagrandin anarog (say that w/ a strong asian accent)*
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19
Q

Which antihistamines are used as anti-emetics?

A

Diphenhydramine

Dimenhydramine

Meclizine

Cyclizine

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20
Q

-prazole

A

GI drug

Decrease acid formation

Mech: ATPase inhibitor

Known as proton pump inhibitor (PPI) but actually irreversibly inhibit ATPase required to drive H+ pump

Best available class of GI drugs

Prodrug-activated by acid

They are weak bases though→ stay in parietal cell

SE:

  • Hypochlorhydria-lack of H+ production
  • Decrease Ca absorption→osteoporosis
  • Decrease Vit B12 absorption
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20
Q

Isophane

A

Tx: Diabetes

Designer insulin

Protamine insulin

Intermediate acting

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21
Q

Glargine

A

Tx: Diabetes

Designer insulin

Short acting (24+ hrs)

Determined to get large (that a long time)

Detemir +glargine=long acting insulins

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22
Q

-setron

A

Ondansetron

Granisetron

Dolasetron

Palonosetron

Anti-emetic (for IBS+chemo)

Mech: 5HT receptor blocker

Affect CTZ +rec. in gut

SE: Constipation

_SE_lective _T_e_R_minators _O_f _N_ausea

-SETRON

-setron blocks serotonin

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23
Q

Echinacea

A

Use:

  • Upper resp. inf.
  • Wound healing
  • Antifungal

Can decrease sympt. of flu if used early

SE:

  • Allergies
    • Related to ragweed
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24
Q

Cinecalcet

A

Tx: Ca disorders + hyperparathyroidism

Mech: Calcium mimetic

Sensitizes parathyroid Ca receptors to Ca→Decrese PTH secretion

Like there is a lot of Ca around

SE

  • Hypocalcemia
  • Nausea
  • Diarrhea
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24
Q

Fluoride

A

Tx: Ca disorders

Effects: Increase osteoblasts

Makes bone harder but more brittle

Not for osteoporosis

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25
Q

Cyclizine

A

Anti-emetic–Antihistamine

Mech: Block H1 receptor

SE: Anticholinergic effects

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26
Q

Diphenoxylate

A

Tx: Diarrhea

Narcotic agent

Mech: act a specific receptor

Acts primarily in gut

Opiate like effects in CNS though too

Given in comb w/ atropine to avoid abuse

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27
Q

Nabilone

A

Anti-emetic–THC derivative

Mech: Bind cannabinoid receptor

SE: Increased appetite

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29
Q

What are the osmotic cathartics?

A

MgSO4

Mg(OH)2

Polyethylene glycol

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30
Q

Compazine

A

Anti-emetic

Mech: DA blocker

*Related to anti-psychotic drugs *(phenothiazine)

SE: Extrapyramidal effects

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32
Q

Magnesium hydroxide

Milk of magnesia

A

Antacid

Speed-slow

Duration-medium

Neutralizing-high

SE:

  • Laxative
  • Some Mg toxicity
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32
Q

Cascara

A

GI Drug

Cathartic–Gastric Irritants

Mech: Stimulate gastric nn

Increase motility

Decrease electrolyte secretion into gut

SE:

  • Nephritis
  • Liver damage
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33
Q

Ginseng

A

Uses: Increase energy

No clear effect

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35
Q

Scopolamine

A

Tx: Diarrhea

Anti-cholinergic agent

Mech: Blocks muscarinic receptor

SE: Many systemic

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35
Q

Aminobisphosphonates

A

other -dronates

Aminobisphosphonates are more potent

Tx: Ca disorder

Mech: Enzyme inhibitor (farnesyl pyrophosphate synthetase)

Inh. enzyme in mavalonic acid synthesis pathway→abnormal cytoskeletal structure in osteoclasts

Pyrophosphates have an affinity for Ca and are incorporated into bone

When ingested by osteoclasts→decrease activity and apoptosis

T1/2: Many years

Use: 1st line tx for osteoporosis and pagets

Used in tx of MM too

SE:

  • GI upset, peptic ulcers
  • Inflammation of eye
  • IV infusions cause 1st dose effect (flu-like symptoms)
  • Osteonecrosis of jaw
    • Decrease blood flow to area
    • Esp in pts w/ lost of dental disease/surgery
    • Bone w/ bisphosphonates may be more susceptible to infections

Belly ache and peptic ulcers

Infections/Infarcts

Swollen eye

First dose eff (IV)→Flu-like symptoms

Osteonecrosis of jaw

36
Q

Bisphosphonates

A

Tiludronate

Etidronate

Bisphosphonates are less potent

Tx: Ca disorder

Mech: Enzyme inhibitor

Cause formation of abnormal ATP→inh ATP requiring enzymes

Pyrophosphates have an affinity for Ca and are incorporated into bone

When ingested by osteoclasts→decrease activity and apoptosis

T1/2: Many years

Use: 1st line tx for osteoporosis and pagets

Used in tx of MM too

SE:

  • GI upset, peptic ulcers
  • Inflammation of eye
  • IV infusions cause 1st dose effect (flu-like symptoms)
  • Osteonecrosis of jaw
    • Decrease blood flow to area
    • Esp in pts w/ lost of dental disease/surgery
    • Bone w/ bisphosphonates may be more susceptible to infections

Belly ache and peptic ulcers

Infections/Infarcts

Swollen eye

First dose eff (IV)→Flu-like symptoms

Osteonecrosis of jaw

37
Q

Infliximab

A

Tx: IBS

Mech: Binds TNF alpha

40
Q

Calcium carbonate

CaCO3

A

Antacid

Speed-rapid

Duration-medium

Neutralizing-high

SE:

  • Constipating
  • Hypercalcemia
41
Q

Cranberry

A

Uses: UTI

May inh. recurrent UTI

Not helpful for current inf.

Mech: Proanthrocyanadin prevents bact from binding to UT cells

May also acidify urine

SE:

  • Inh P450
43
Q

Sodium Bicarbonate

NaHCO3

A

Antacid

Speed-rapid

Duration-short

Neutralizing-high

SE:

  • CO2 production
  • Belching
  • Na may compromise low sodium diets
  • Systemic absorption
    • Contains Na
    • Important in those w/ kidney dysfunction
43
Q

Bran

A

GI Drug

Cathartic–Bulk adding agent

Mech: Like eating fiber

45
Q

Loperamide

A

Tx: Diarrhea

Narcotic agent

Narcotic DOC for diarrhea

Mech: act a specific receptor

Acts ONLY in gut–no CNS effects

46
Q

Crofelemer

A

Tx: Diarrhea

Mech: Blocks Cl channel in gut

Also decreases secretion of Na and H2O

CrofeLemer blocks CL channels

  • or *
  • CROws block the CLouds*
  • CROfelemer blocks CL channels*
46
Q

Acarbose

A

Rosiglitazone

Pioglitazone

Tx: Diabetes

Glucose abs. delayers

Mech: Inh. alpha glucosidase

Prevents breakdown of complex carbs in gut

SE:

  • Unabsorbed carbs ferment in gut
    • Cramps
    • Diarrhea
    • Flatulence
  • A-carb-ose*
  • No-carb-abs.*
47
Q

-gliptin

or

-glyptin

A

Sitagliptin

Saxagliptin

Linaglyptin

Alogliptin

Tx: Diabetes

Incretin enhancer

Mech: Inh DPP-4 Enzyme →prevent incretin metab

Orally

Often used in combo w/ other drugs

  • Put a lip of dip in (oral). Dip comes in a tin*
  • G-_LIP_-TIN are DPP inh. Taken orally.*
48
Q

Valerian

A

Uses: Sedative

Mild sedative effect

Mech: Increase GABA

SE:

  • Hepatotoxicity
  • Dont use w/ anti-dep
49
Q

Raloxifene

A

Tx: Ca disorders +estrogen dependent breast cancer

Mech: Activates estrogen receptors in bone

Blocks estrogen receptors in breasts

Estrogen analog

SERM-selective estrogen receptor modulator

Inh. osteoclast activity

SE

  • Pulmonary embolisms
  • Stroke
  • Preg. cat X
  • Raloxifene like Tamoxifene affect estrogen receptor*
  • SE=SEX*

Stroke

Embolism (pulmonary)

X (preg cat.)

50
Q

Metformin

A

Tx: Diabetes

Insulin enhancers

Mech: Act. protein kinase→

Increased glc abs. by muscle

Decreased glc production by liver

SE:

  • Lactic acidosis (potentially fatal)
  • Weight loss due to anorexia
  • George Foreman was an American Professional (Kick)boxer *
  • Metformin Activates Protein Kinase*
  • He worked out so hard he had lactic acidosis and had to be anorexic to make his weight class*
51
Q

Kola nut

A

Caffeine

Increased HR

Insomnia

53
Q

Bismuth subsalicylate

A

GI drug-Enhance mucosal defense

Anti-diarrheal agent–absorbing agent

Mech: Increase mucous production in stomach

Inh. growth of H. pylori

Unpleasant taste+odor

SE:

  • Long term use→Darkening of feces, tongue, and teeth
54
Q

What are the bulk adding agents?

A

Bran

Methylcellulose

Polycarbophil

Psyllium

56
Q

Meclizine

A

Anti-emetic–Antihistamine

Mech: Block H1 receptor

SE: Anticholinergic effects

57
Q

Gli–ide

or

Gly–ide

A

Glipizide

Glyburide

**Glimepiride **(most potent)

Tx: Diabetes

Oral hypoglycemic agents

Second gen sulphonylureas

More rapid onset and longer duration

Mech: K channel blockers

Block K channels on B cells →Increase Ca→Insulin secretion

Contra/Indications:

  • Do not use if you have renal or hepatic damage
  • Not overweight
  • Have some islet fxn

SE: Less than 1st gen

  • Hypoglycemia and hypoglycemia coma
    • More common in drugs w/ longer duration
  • Can be teratogenic
  • Can increase death due to cardiovascular problems
57
Q

-gliflozin

A

Canagliflozin

Dapagliflozin

Empagliflozin

Tx: Diabetes

Inh. of glc resorption by kidney

**Mech: **Inh. SGLT2 (Na-glc cotransporter)

in PCT–allows kidney to eliminate blood glc

SE:

  • Hypotension
  • Hypokalemia
    • Due to increased urine output
  • Gential fungal inf
    • Urine loaded w/ glc
59
Q

Senna

A

GI Drug

Cathartic–Gastric Irritants

Mech: Stimulate gastric nn

Increase motility

Decrease electrolyte secretion into gut

SE:

  • Nephritis
  • Liver damage
60
Q

Soy

A

Uses:

  • Hyperlipidemia
  • Osteoporosis
  • Menopause

Decreases LDL

Decreases Menopausal symptoms

Mech: Metab. to estrogen like compound

SE: Allergic rxns

62
Q

Diphenhydramine

or

Dimenhydramine

A

Anti-emetic–Antihistamine

Mech: Block H1 receptor

SE: Anticholinergic effects

63
Q

(Apo)morphine

A

Emetic–central stimulant

Mech: Stimulates DA sites in CTZ

64
Q

Dioctal sodium sulfosuccinate

A

GI Drug

Cathartic–Stool softener

Detergent

Mech: Emulsifies contents of colon

65
Q

Mineral oil

A

GI Drug

Cathartic–Stool softener

Mech: Acts like a lubricant

Why mineral oil should NOT be used:

  • Prevents fat soluble vitamin absorption
  • Aspiration pnemonia →may damage lungs
  • May contain carcinogens
67
Q

Regular human insulin

A

Tx: Diabetes

Designer insulin

Short acting (2-5 hrs)

Afrezza is the inhaled form

68
Q

Tolazamide

A

Tx: Diabetes

Oral hypoglycemic agents

First gen sulphonylureas

Mech: K channel blockers

Block K channels on B cells →Increase Ca→Insulin secretion

Duration: 12-60 hrs

Contra/Indications:

  • Do not use if you have renal or hepatic damage
  • Not overweight
  • Have some islet fxn

SE:

  • Hypoglycemia and hypoglycemia coma
    • More common in drugs w/ longer duration
  • Can be teratogenic
  • Can increase death due to cardiovascular problems
69
Q

Lispro

A

Tx: Diabetes

Designer insulin

Short acting (2-5 hrs)

70
Q

St Johns Wort

A

Uses:

  • Mild depression
  • anxiety

As eff as standard anti-dep.

Mech: Inh. reuptake of NE, 5HT, DA

SE:

  • Phototoxicity
    • Other allergic rxns
  • In breast milk→lethargic baby
  • Induces P450
    • Wafarin
    • BC
  • Anti-depressant interactions
71
Q

Bisacodyl

A

GI Drug

Cathartic–Gastric Irritants

Mech: Stimulate gastric nn

Increase motility

Decrease electrolyte secretion into gut

SE:

  • Nephritis
  • Liver damage
71
Q

Glulisine

A

Tx: Diabetes

Designer insulin

Short acting (2-5 hrs)

72
Q

Denosumab

A

Tx: Ca disorders

Mech: Blocks a receptor (RANKL)

RANKL required for osteoclast production, activity, and survival

Given every 6 mnths

SE:

  • Hypocalcemia
  • Osteonecrosis of jaw
  • Skin inf.

Deno- SHO

Skin inf.

Hypocalcemia

Osteonecrosis

73
Q

Atropine

A

Tx: Diarrhea

Anti-cholinergic agent

Mech: Blocks muscarinic receptor

SE: Many systemic

74
Q

-glutide

A

**Liraglutide **(Inj 1x/day)

Albiglutide (Inj. 1x/week)

Tx: Diabetes

Incretin enhancer

Mech: Bind to and activate receptors on B cell

Incretin analog

SE:

  • Thyroid tumor
  • I want my glutes to be as hard as concrete*
  • -glutide to be as hard as incretin*
76
Q

-glitazone

A

Rosiglitazone

Pioglitazone

Tx: Diabetes

Insulin enhancers

Mech: Act. PPAR→

Increased insulin receptor response

Increased # insulin receptors

Increased glc uptake by cells

SE:

  • Wt gain
  • Edema
  • Fractures of arms and legs
  • Macular edema
  • Cardio problems
    • MI
77
Q

Exenatide

A

Tx: Diabetes

Incretin enhancer

Mech: Bind to and activate receptors on B cell

Analog of GLP-1 (incretin)

Not broken down by DPP-4

Injection 2x/day

SE:

  • Pancreatitis
78
Q

Chlorpropamide

A

Tx: Diabetes

Oral hypoglycemic agents

First gen sulphonylureas

Mech: K channel blockers

Block K channels on B cells →Increase Ca→Insulin secretion

Duration: 60+ hrs

Contra/Indications:

  • Do not use if you have renal or hepatic damage
  • Not overweight
  • Have some islet fxn

SE:

  • Hypoglycemia and hypoglycemia coma
    • More common in drugs w/ longer duration
  • Can be teratogenic
  • Can increase death due to cardiovascular problems
80
Q

-glinide

A

Repaglinide

Nateglinide

Tx: Diabetes

Oral hypoglycemic agents

Sulphonylurea-like agents

Rapid onset, short duration

Mech: K channel blockers

Bind diff site on K channel

Block K channels on B cells →Increase Ca→Insulin secretion

Contra/Indications:

  • Do not use if you have renal or hepatic damage
  • Not overweight
  • Have some islet fxn

SE:

  • Hypoglycemia and hypoglycemia coma
    • More common in drugs w/ longer duration
  • Can be teratogenic
  • Can increase death due to cardiovascular problems
81
Q

Erythromycin

A

Tx: Gastroparesis

prokinetic agents–agents that increase stomach emptying rate

Mech: Acts directly on motilin receptor

Route: Oral but IV possible if oral is not

SE:

  • ototoxicity
  • pseudomemb. colitis
  • cardiac arrythmia
    • Especially if metabolism is inh by P450
  • Remember erythro is a macrolide*
  • Motiliy*
  • Arrythmias*
  • Cholesteric toxicity (liver tox)/Colitis*
  • Restricts P450*
  • Ototoxicity*
82
Q

Glucocorticoids

A

Effects: Inh. osteoblasts

So bone loss

83
Q

Antibiotic combo for H pylori infection

A

GI drug-Enhance mucosal defense

Metronidazole

+/-

Amoxicillin

+/-

Clarithromycin

+/-

Tetracycline

84
Q

Alvimopan

A

Tx: Gastroparesis

prokinetic agents–agents that increase stomach emptying rate

Mech: Blocks opiate receptor in gut but not anywhere else

Blocks constipation due to post op opioid use

85
Q

Simethicone

A

Tx: Diarrhea

Mech: Changes gas surface tension of gas pocket in gut

86
Q

MgSO4

A

GI Drug

Cathartic–Osmotic agent

87
Q

Difenoxin

A

Tx: Diarrhea

Narcotic agent

Active metabolite of diphenoxylate

Mech: act a specific receptor

Acts primarily in gut

Opiate like effects in CNS though too

Given in comb w/ atropine to avoid abuse

88
Q

Ginko

A

Uses:

  • Dementia
  • Intermittent claudication–pain in leg

About as eff. as tacrine for tx of alzheimer’s

But tacrine isn’t really effective at all

SE:

  • Inh platelet activating factor
  • Decrease clotting
  • Interacts w/ warfarin
89
Q

Methylcellulose

A

GI Drug

Cathartic–Bulk adding agent

Mech: Like eating fiber

90
Q

Flax oil seeds

A

Uses:

  • Constipation
  • Diarrhea
  • IBS
  • Diabetes
  • Arthritis
  • Atherosclerosis
  • Menopause

May slightly lower total cholesterol

May decrease hot flashes

Mech: Soluble fiber and phyto estrogens

SE:

  • Increase GI act.
  • Allergic rxns
91
Q

Polycarbophil

A

GI Drug

Cathartic–Bulk adding agent

Mech: Like eating fiber

92
Q

Ipecac

A

Emetic–reflex stimulant

Mech: Act. receptors in GI mucosa

Instant severe vomiting

SE: Cardiotoxic

93
Q

Teriparitide

A

Tx: Ca disorders

Mech: PTH analog

Increase osteoblast activity

Daily subQ injections for short periods

High doses→osteoclast stimulation so only given in short bursts

SE-increase incidence of osteosarcoma

95
Q

Which GCs used for IBS

A

Prednisone

Budesonide

96
Q

Lubiprostone

A

GI Drug

Cathartic–Secretion enhancer

Mech: Acts on PGE receptor

PGE1 derivative

Also acts on Cl channel in intestine

97
Q

Detemir

A

Tx: Diabetes

Designer insulin

Long acting (24+ hrs)

Determined to get large (that a long time)

Detemir +glargine=long acting insulins

98
Q

Heparin

A

Effects: Act. osteoclasts

So bone loss

99
Q

-tidine

A

GI drug

Decrease acid secretion

Mech: H2 receptor blockers

SE:

  • Confusion in elderly
  • Bradycardia

Cimetidine:

  • Inh. P450
    • Prevent synth of test.
    • Anti-androgenic
      • Cause gynecomastia
100
Q

Ma huang (ephedra)

A

Use:

  • Weight loss
  • Nasal congestion
  • Asthma
  • Increase athletic performance

Strong CNS stimulant

SE:

  • Stroke
  • Hypertension
  • MI
101
Q

Metoclopramide

A

Tx: Gastroparesis

prokinetic agent–agents that increase stomach emptying rate

Also used for hiccups

Mech: DA and possible 5HT antagonist

Route: Oral or IV

Increase motility w/o secretion (of H or gastrin)

SE:

  • Sedation
  • Depression
  • Parkinson like symptoms

Metoclopramide increases motility

  • All that motility→shakes (parkinson like symptoms)*
  • All those shakes →sedation *
  • All that sedation→depression *
102
Q

Paracalcitrol

A

Tx: Ca disorders

Mech: Vit D analog

Less potent than calcitriol

SE: Hypothyroidism

103
Q

-sala-

A

Sulfasalazine

Mesalamine

Olsalazine

Balsalazide

Tx: IBS–Salicylates

Mech: Decrease PG synth

Online it says mech is unclear–may not be the same as aspirin

Not systemically absorbed-like a topical drug for the stomach

SE:

  • Diarrhea
  • Take 3-5 weeks to work
104
Q

Aspart

A

Tx: Diabetes

Designer insulin

Short acting (2-5 hrs)

105
Q

What are the long acting designer insulins?

A

Detemir

Glargine

Pharm 6 (7 decks)

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