Unit 4 Topic 2 PART 2 Flashcards

1
Q

What are the three types of point mutations

A

Silent mutation, nonsense mutation, missense mutation.

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2
Q

Mutation Definition:

A

A change in a gene or a chromosome relative to the original. Essentially an error in the the copying process of genetic information.

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3
Q

Silent Mutation Definition.

A

These mutations do not affect the sequence of amino acids during translation.

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4
Q

Nonsense Mutation Defintion.

A

A nonsense mutation occurs in DNA when a sequence change gives rise to a stop codon rather than a codon specifying an amino acid.

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5
Q

What is the result of a nonsense mutation occurring?

A

The presence of the new stop codon results in the production of a shortened protein that is likely non-functional.

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6
Q

Missense Mutation Defintion.

A

Change the amino acid specified by a codon, (the amino acid sequence has changed).

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7
Q

What will happen if errors in the genetic sequence occur.

A

The errors can accumulate and thus accumulated over generations and passed down to future generations.

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8
Q

Frameshift mutation definition

A

A mutation that dislocates the translational reading frame.

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9
Q

2 types of frameshift mutations:

A

Insertion and deletion.

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10
Q

Insertion mutation def

A

One or more bases are added to the DNA sequence.

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11
Q

Deletion mutation def

A

One or more bases are added to the DNA sequence.

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12
Q

How is genetic information read?

A

The info is read in codons, three bases at a time.

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13
Q

DO frameshift mutations affect the speed of which genetic information is read?

A

YES

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14
Q

How do environmental mutagens affect mutation rates?

A

They can speed up mutation rates.

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15
Q

Can particular mutations be influenced mutagens Y/N

A

No

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16
Q

What are the three broad categories of mutations

A

Chemicals, radiation and infectious agents

17
Q

X rays are a physical mutagen. What can affect can they have on DNA?

A

They can causes the DELETION of A and G bases, which disrupts the DNA and potentially cause serious damage.

18
Q

What affect does nuclear radiation have on chromosomes?

A

Causes double-strand breaks which results in large segments of chromosomes being rearranged?

19
Q

Mechanism used for programmed cell death.

A

Apoptosis

20
Q

Name 3 forms of (potential) physical mutagens?

A

Gamma rays, X-rays and nuclear radiation.

21
Q

Definition for aneuploidy

A

Aneuploidy is a condition where one or more chromosomes are missing from or added to the normal somatic cell chromosome number.

22
Q

What are aneuploidies usually a result of?

A

Non-disjunction during meiosis.

23
Q

What does Trisomy 21 cause?

A

This condition causes Down Syndrome, where the offspring has two extra female chromosomes.

24
Q

What is the most common cause of down syndrome?

A

Non-disjunction of chromosome 21 during meiosis (95% of all cases)