unit 3: rheum Flashcards
what color is non-inflammatory synovial fluid?
clear
what color is mild inflammatory synovial fluid?
translucent
what color is purulent synovial fluid?
opaque
true or false: when aspirating a knee it is ok to insert needle thru an area of cellulitis or other skin disorder?
false…. you dont want to introduce bacteria from outside.
your pt is on coumadin and you want to aspirate their joint… what do you check? what are the parameters? what gauge do you use?
- INR
- MUST BE LESS THAN 3
- small gauge (like 22g)
true or false: joint aspiration falls under the APRN’s scope of practice
*trick question- varies by state
wbc count of normal synovial fluid?
<2k
*would indicate non-inflammatory condition
wbc count of inflammatory synovial fluid?
2k-75k
wbc count of purulent synovial fluid?
100k
true or false: bloody joint effusions are usually caused by traumatic aspiration
TRUE
3 clues to help you dx rheum:
- +/- _______
- # of ______ involved
- _______ of joint involved
- absence or presence of inflammation
- number of joints involved
- site of joint involved
if inflammation is present what 3 diseases should you consider?
- RA
- SLE
- gout
if inflammation is absent what disease should you consider?
OA
monoarticular joint involvement… what 5 diseases should you consider?
- gout
- trauma
- septic arthritis
- lyme
- OA
Get LOST
gout, lyme, OA, SA, trauma
oligoarticular involvement means what?
2-4 joints
polyarticular means what?
5+ joints
oligoarticular involvement…. what 2 diseases should you consider?
- Reactive arthritis
2. psoriatic arthritis
polyarticular involvement… what 2 diseases should you consider?
- RA
2. SLE
distal interphalangeal (DIP) joint site… what 2 diseases?
- OA
2. PA
metocarpophalangeal and wrist involvement… what 2 diseases?
- RA
2. SLE
first metatarsal phalangeal… what 2 diseases?
- OA
2. gout
OA def: ________ of the cartilage and ______ of the bone
- degeneration of the cartilage
* hypertrophy of the bone
______ is the most common form of joint disease
OA
OA is more common in women or men?
women
OA usually flares ______ (#) joint at a time
1
onset of OA is abrupt or insidious?
insidious, gradual
what do you expect ESR and synovial fluid to show in a pt with OA?
- ESR IS NOT ELEVATED
* syn fluid NON INFLAM
2 radiologic findings with OA?
- narrowing of joint space
* osteophyte formation
2 ways to prevent OA
- weight reduction
2. normal vitamin D levels
first line treatment for OA?
tylenol
is exercise indicated in the treatment of OA?
YES, regular exercise
do splints and compression gloves help in treatment of OA?
YES
______ is the most common cause of gastric ulcer, perf, and hemmorhage (for the sake of this chapter…)
NSAIDS
what should you use to reduce risk of GIB in pts taking nsaids?
PPI
NSAIDS should be administered cautiously in what groups? (5)
- over 70
- anticoagulated
- taking corticosteroids
- hx of PUD
- hx alcoholism (dec. clotting times due to liver dysfunx)
how many times a year can you give your pt intra articular steroid injections?
NO MORE THAN 4
injections of the _____ are not recommended for OA
hand
hip and knee replacements are a good choice for OA pts w what restriction
those who have ambulation restrictions
gouty arthritis is ideopathic or hereditary?
hereditary
gouty arthritis more common in men or women?
men
gouty arthritis more common in men over ______y
30
gouty arthritis acute or gradual onset?
acute
gouty arthritis mono, oligo, or poly articular?
MONO
usual site of gouty arthritis?
MTP
first metaphalangeal joint
hyperuricemia is associated with what level of uric acid?
> 6.8
pts with gout are at increased risk for what other undesired condition?
kidney stones. check for them
uric acid kidney stones are common in 5-10% of pts with uric acid level >?
13
another name for the MTP joint when gouty is?
podagra
true or false. during an acute gout attack, the WBC count is elevated
TRUE
pts with gout have a higher INCIDENCE of what 5 other DIAGNOSES/disease processes (think of vessel inflammation related dx and you’ll 4 of them…. the 4th one is partially a consequence of the remaining dx)
- HTN
- DM
- CKD
- atherosclerosis
- hyperTRIGS
2 options for gouty arthritis treatment include?
- NSAIDS
* colchicine
what is the two step loading dose treatment with colchicine?
- 1.2mg NOW
* 0.6mg one hour later
2 NSAID treatments for gouty arthritis
- naprosyn 500mg BID
* indomethicin 25-50mg q8h
undesirable side effect of colchicine?
diarrhea
- allopurinol starting dose?
- titrate up every _____ weeks?
- usual dose to decrease symptoms?
- max dose?
- 100mg daily
- 2-5w
- 300mg
- 800mg daily
allopurinol and what drug (abx) causes a rash in approx 20% of pts?
ampicillin
use allopurinol cautiously in pts with _______
CKD
true or false: allopurinol and colchicine may be taken concurrently?
FALSSSSSSSSE
*colcrys loading for acute attack… allo for prevention
all meats are high or low purine?
HIGH
organ meats are high or low purine?
HIGH
seafood is high or low purine?
HIGH
sadly…. what alcoholic bev is high purine?
BEEEEER (and all alc) but esp beer due to the YEAST
other foods high in purine: all veg with one grain
BLOP, SCAM
BLOP: beans, peas, lentils, oatmeal
SCAM: spinach, cauliflower, asparagus, mushroom
teach wants us to know high fructose corn syrup is risk factor food for?
gouty arthritis
thiazide and loop diuretics are contraindicated in gout bc??
*inhibit renal secretion of uric acid
what supplement commonly used as an alternative to statins can raise serum uric acid levels?
niacin
corticosteroid dose for gout? if using…
prednisone 30-40mg daily for 2-5d then taper
physicain may initiate urate-lowering therapy when pt has had ______+ gout attacks in one year
2
goal of urate lowering theraoy is maintain serum uric acid at or below??
6mg/dL
recheck uric acid levels about _____ weeks after initiation
- she keeps saying shell check her pts around a month of treatment…
RA morning stiffness lasts longer than _____min
30
palmar erythema is a hallmark of which disorder?
RA….. palmAR
name 4 extra-articular manifestations of RA… remember its an INFLAM process…
- subcu nodules
- interstitial lung disease
- pericarditis
- vasculitis
most common cause of MORTALITY in pts with RA…
CVD… due to chronic inflam
multiple joints are involved with swelling, tenderness, and pain…. which one?
RA
____% of RA pts have subcu nodules… these may also be found in other tissues such as….
- 20%
- lungs
- sclera
- other tissue
dryness of eyes, mouth, and mucous membranes is AW what disorder other than sjogrens?
RA
when and only when may you draw an ANTI CCP antibody on your pt?
only after a positive RA factor. if RA negative then its not RA….
what lab test is most specific for RA?
Anti CCP antibodies
in RA… are ESR and CRP levels elevated?
YES, its inflammatory process
in RA is the platelet count elevated or decreased?
elevated
____% of deaths in pts w RA is attributed to ______ due to _______ (3 words)
- 40%
- CVD
- small vessel vasculitis
initial labs to be drawn on someone you suspect to have RA? 7, maybe 8… not a trick question
CBC CMP TSH ESR ANA RA factor uric acid maybe CRP (CC TEARum)
methotrexate was initially used as a ______ drug
cancer, chemo
treatment of RA and similar diseases requires high or low doses of methotrexate to be effective?
*lower
methotrexate works to decrease ______ and limit ________
- inflam
* joint damage
how often is methotrexate taken?
weekly
true of false: methotrexate comes in pill, liquid, and injection form
*true
tell me the lab monitoring for methotrexate. what and when
- CBC, CMP
- baseline
- q4-6w for first 3mo
- then q8-12w
what blood abnormality does methotrexate cause?
*pancytopenia
=low count of reds, whites, and platelets (yes I had to google the def lol)
methotrexate can cause ______ and ______ failure (hint… this is why we draw a CMP)…
- liver
* renal