Unit 3 - Metabolism Flashcards
5 Examples of cellular activities that require energy:
cell division
synthesis of proteins from amino acids
active transport
muscle cell contraction (in animal bodies)
transmission of nerve impulses (in animal bodies)
Energy
= ability to do work
Sum of all chemical reactions occurring in a living cell or organism
= it’s metabolism
Building up rxn
anabolic
breaking down rxn
catabolic
Eukaryotic cells =
organisms that contain a nucleus surrounded by a membrane and specialized organelles not present in prokaryotic cells. These types of cells are found in trees, protozoa (amoeba), and vertebrates (animals with a backbone)
Prokaryotic cells =
typically unicelllar microorganisms that do not have a distinct nucleus or membrane bound organelles. An example of this are bacteria.
Energy from food is typically measured in
calories (cal), but in some scientific literature is in Joules instead.
1 calorie =
amount of energy to raise temperature of 1 gram of water by 1 degree celsius.
1 cal = 4.184 kJ
Daily energy requirements, for basic body functions, such as breathing, digesting, and thinking can be calculated
basal metabolic rate/BMR
RMR
resting metabolic rate - amount of energy used by a person at rest over a 24-hour period. This is the amount of energy required to run the basic energetic needs of organs like the heart, lungs, liver, and kidneys.
BEE
basal energy expenditure - a 24 hour estimation of the number of calories you burn maintaining your most basic bodily functions, such as breathing, circulating blood and growing and repairing cells
REE
resting energy expenditure - determines the number of calories you burn in a 24 hour period maintaining basic bodily functions, but also includes the number of calories burned eating and conducting small amounts of activity.
BMR is a more accurate measure because
RMR is more general than specific; BMR targets specific body functions and measures different metabolic rates after fast and at rest at different periods
Three of the most common health problems resulting from our modern lifestyle include:
Diabetes
Obesity
Cardiovascular disease
Type 2, diabetes usually results from:
The pancreas’s gradual inability to produce insulin
Cells becoming resistant to absorbing glucose, a type of sugar, from the blood
Individuals with the lack of ability to control blood sugar levels
bmi
body mass index calculated by dividing your weight (in kilograms) by the square of your height (in metres).
Two of the most common cardiovascular problems in Canada are
heart attacks and strokes.
coronary artery disease occurs when
fatty materials, calcium, and scar tissue combine into a sticky substance called plaque, which is carried in the blood. The plaque can accumulate on the walls of coronary arteries and narrow their diameter.
In the human body and ecosystems, the ‘currency’ of energy is captured and managed by one of the most basic laws of science which states that energy cannot be created or destroyed but it can be changed from one form to another. This is called the
the Law of the Conservation of Energy.
All forms of energy can be divided into two types:
kinetic and potential energy.
Kinetic energy
is the energy that causes objects to move. This is the energy that is being used up.
Potential energy
is energy that is stored for later use.
Thermodynamics =
science that deals with the relationship between all forms of energy.
First law of thermodynamics =
energy can be changed from one form to another, but it cannot be created or destroyed. Amount of energy in universe is always conserved. However when energy is transformed, there is always some loss of energy - it is not destroyed it just becomes unusable for doing any further work.
Second law of thermodynamics =
disorder (aka entropy) in the universe is always increasing. Each time energy is used, some will be converted (lost) to heat (random motion). Every time energy is transformed into another form, some of the potential energy is converted into heat, but the heat is not always able to do further work. Some of the heat produced becomes permanently unavailable.
This means that disorder is always more likely than order.
Endergonic reactions
Reactions in which the reactants have less energy than their products; reaction absorbs energy
Exergonic
when reactants have more energy than products; releasing energy
Recall the acronym OIL RIG.
OIL
Oxidation is Loss of Electrons/Energy (and gain of oxygen). Substances that are oxidized are called reducing agents because they cause the reduction of other substances.
RIG
Reduction is Gain of Electrons/Energy (and loss of oxygen). Substances that are reduced are called oxidizing agents because they cause the oxidation of other substances.
Redox reactions occur when
both oxidation and reduction reactions occur simultaneously. When a reducing agent and an oxidizing agent react, a redox reaction takes place
Reduced molecules or atoms are raised to higher energy levels because
electrons repel each other. Adding more electrons to an atom is like pressing down on a spring. Just as pushing on a spring increases the potential energy of the spring, adding more electrons increases the potential energy of the atom.
Specialized molecules, called energy carriers or coenzymes, become reduced and oxidized by
electrons shuttled from one enzyme to the next through metabolic pathways, delivering or harvesting energy at each stage (ETC/Active Transport)
how (NAD+) becomes NADH
Nicotinamide adenine dinucleotide ; becomes NADH through reduction where it accepts a H proton and 2 electrons and gains energy
ATP
adenosine triphosphate ; currency of the cell; 54kJ of energy
Cells get energy from ATP by
hydrolyzing the unstable high-energy bond between the second and third phosphate of the ATP, which creates the two products, adenosine diphosphate (ADP) and inorganic phosphate (Pi), and the release of 30 kJ/mol of energy.
Aerobic cellular respiration is
the process of capturing the energy of the electrons that are shared in the covalent bonds (C-H) of glucose, using oxygen as a final electron acceptor. The process results in the release of energy and the formation of water and carbon dioxide as products
Aerobic cellular respiration can be broken
down into four main stages:
Glycolysis
Pyruvate oxidation
Krebs cycle
Electron transport chain/Chemiosmosis
energy-carrying coenzymes, enzymes, and specialized structures within the mitochondria are used by aerobic CR to
incrementally extract the energy of the electrons as they move toward their final electron acceptor, oxygen.
cristae
folds in the inner membrane of the mitochondrion that provide greater surface area and specialized environments for energy carrying reactions
matrix (mitochondrion)
space within the inner membrane of the mitochondrion where most reactions take place
FADH2 is oxidized to
FAD
describe glycolysis
- 10-step enzyme catalyzed reaction that takes place in cytoplasm of eukaryotic cells
- Each glucose (6 Carbons) enters the cytoplasm of the cell
- split into two 3-carbon molecules that eventually become pyruvate (2 × 3 Carbons).
- prepares the energy-rich glucose molecule for the extraction of the energy stored in its bonds.
- energy has first to be invested to destabilize the glucose molecule.
- Two ATP molecules are expended initially by the cell
- four ATP and two NADH molecules are then produced.
- net yield of energy-carrying products is two ATP and two NADH.
Aerobic cellular respiration is
the process of capturing the energy of the electrons that are shared in the covalent bonds (C-H) of glucose, using oxygen as a final electron acceptor. The process results in the release of energy and the formation of water and carbon dioxide as products
The glycolysis stage of aerobic cellular respiration does not require
oxygen