Unit 3 Flashcards
What causes diabetes insipidus?
caused by a deficiency of ADH from the posterior pituitary gland
How much urine do kidneys usually pass in a day?
1-2 quarts
How much urine do kidneys pass in a day with DI?
3-20 quarts
What are the signs and symptoms of diabetes insipidus?
polyuria and polydipsia. urine specific gravity <1.005 output not controlled by limiting intake causing dehydration with hypernatremia nocturia dry skin, dizziness, confusion, nausea
What is the characteristics of the urine with diabetes insipidus?
dilute, almost clear, and odorless.
What are causes of diabetes insipidus?
CVA, Head injury, aneurysm, intracranial tumor, irradiation of pituitary gland.
What are the diagnostic test for diabetes insipidus?
fluid deprivation test
decrease urine osmolality and urine specific gravity <1.005
CT or MRI to assess for tumors
What is a fluid deprivation test?
measures changes in patients body weight and urine concentration after restricting liquid intake. fluids withheld for 8-12 hours, BP monitored. if BP drops significantly or patient loses 3-5% of body weight. blood is drawn to check sodium levels
What is the results of a positive fluid deprivation test?
serum sodium >145 and serum osmolality >300
What are the goals of medical management of diabetes insipidus?
replace ADH
replace fluids
identify and correct the underlying cause
What medication is used to replace ADH?
Desmopressin (DDAVP), also known as vasopressin
What is important with I&Os for patients with diabetes insipidus?
do NOT limit PO intake. match I&Os to prevent dehydration, hypovolemia, and hypernatremia.
What is syndrome of inappropriate antidiuretic hormone (SIADH)?
excessive amount of ADH. causes kidney to reabsorb H2O and decreases urine output resulting in water retention. low sodium levels due to hemodilution.
What are the causes of SIADH?
CNS disorders, tumors to the brain and/or neck. pituitary tumors. or head injuries.
pain, stress, exercise, and low blood sugar levels.
secondary to meds, like NSAIDS or psychotropic meds.
What are signs and symptoms of SIADH?
hyponatremia- sodium <125
H2O retention progressing to H2O intoxication.
weakness, muscle cramps. anorexia. nausea, headache, diarrhea, lethargy, disorientation, irritability. weight gain. seizures.
What are the diagnostic tests for SIADH?
lab tests for serum sodium, serum osmolality. (both will be low)
high urine osmolality and urine specific gravity >1.030
What is the medical management of SIADH?
Eliminate underlying cause.
fluid restriction - 500 to 1000 mL/day
furosemide
monitor K, Na, I&Os, daily weights, and neuro checks
What hormones are secreted by the adrenal glands?
glucocorticoids (cortisol) mineralocorticoids (aldosterone) sex hormones (androgens and estrogens)
What is cortisol?
is a glucocorticoid produced by the adrenal glands. helps maintain BP and heart and blood vessel function. slows the immune systems inflammatory response and regulates metabolism.
What is adrenocortical insufficiency (Addison’s disease)?
the adrenal glands are damaged and cannot produce enough of the adrenal hormones cortisol and aldosterone
What is aldosterone?
a mineralocorticoid produced by the adrenal glands. helps maintain BP, and balance sodium and potassium in the bloodstream.
What is the cause of Addison’s disease?
autoimmune disorders are the primary cause. or infections such as TB, HIV/AIDS, and meningitis. adrenalectomy, pituitary hypofunction, or metastatic tumors. or medications and stopping corticosteroid medications abruptly.
What are signs and symptoms of Addison’s disease?
muscle weakness, anorexia, GI symptoms, fatigue, dark pigmentation of the skin and mucosa, hypotension, low blood glucose, low serum sodium. high serum potassium. mental changes. apathy. emotional lability, confusion.
What is Addisonian crisis?
severe adrenal insufficiency
What are signs and symptoms of Addisonian crisis?
dehydration, sudden severe pain in lower back, abdomen, or legs. cyanosis. and the classic signs of circulatory shock: pallor, apprehension, rapid and weak pulse, rapid respirations, and low blood pressure
What can cause Addisonian crisis in Addison’s disease patients?
overexertion, exposure to cold, or acute infection
What are risk factors for Addisonian crisis?
someone with underlying adrenal hypofunction who undergo stressful events such as trauma, surgery, pregnancy, and infections
What are the diagnostic tests for Addison’s disease?
hormonal blood and urine tests, checking adrenocortical hormone levels and ACTH levels.
ACTH stimulation test.
labs checking for hyponatremia, hypoglycemia, and hyperkalemia.
CT/MRI, Abdominal US
Antibody tests checking for autoimmune disorders
What is an ACTH stimulation test?
injection of synthetic ACTH given, blood levels are then checked.
What results would people with Addison’s disease have with an ACTH stimulation test?
would have little or no increase in cortisol levels
What is the treatment for Addison’s disease?
monitor vitals - give vasopressors (dopamine) for persistent hypotension.
antibiotics for infections to prevent crisis.
Chronic Addison’s disease - lifetime of replacement corticosteroids (prednisone, hydrocortisone, or dexamethasone) and mineral corticoids (fludrocortisone)
if under stress, may need additional doses of corticosteroids to prevent crisis.
What is the recommended diet for patients with Addison’s diease?
high in sodium, low in potassium
What is the priority with Addisonian Crisis?
Treat shock
How do you treat shock in Addisonian crisis?
IV fluids and corticosteroids (hydrocortisone or dexamethasone)
What must you assess with Addison’s disease?
orthostatic BPs. skin turgor and color. weight loss. muscle weakness, or fatigue.
What are signs and symptoms of Addisonian crisis?
shock, hypotension, rapid/weak pulse, tachypnea, pallor, weakness.
What should you avoid with Addison’s disease?
physical stressors, over exertion. cold exposure, infection, and emotional distress.
What is Cushing’s Syndrome (Adrenocortical Hyperactivity)?
too much hormone cortisol is made
What are the causes of Cushing’s syndrome?
long term, high dose use of cortisol-like glucocorticoids. Pituitary tumors, Ectopic ACTH-producing tumors, adrenal tumors.
Who is most likely to experience Cushing’s syndrome?
women > men ages 30-50 people with Type 2 Diabetes HTN high BG levels over time
What are signs and symptoms of Cushing’s disease?
moon face, buffalo hump, HTN, mood swings, increased hair, edema. truncal obesity with thinner extremities. muscle wasting. weakness. skin conditions. easy bruising, purpura, skin ulcers.
What are the diagnostic tests for Cushing’s Syndrome?
two of the following to confirm: 24 hour urinary free-cortisol test late-night salivary cortisol test low-dose dexamethasone suppression test. labs - elevated cortisol, hyperglycemia, hypernatremia, hypokalemia Imaging Tests- CT/MRI
What is the medical management of Cushing’s Syndrome?
treat causative factor.
If removal of tumor, may need post-op hormone replacement to avoid Addison’s disease.
If not removed, adrenal inhibitors may be used (metyraprone, aminoglutethimide, mitotane, nizoral)
What are the complications of Cushing’s syndrome?
osteoporosis, bone loss and fractures. heart attack, stroke, high BP, high cholesterol levels. DVT's/PE infection depression, memory loss insulin resistance, type 2 diabetes