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Pathology > Unit 2 Hematology lab values tests > Flashcards

Unit 2 Hematology lab values tests Flashcards

1
Q

Bone marrow cellularity

A

Ratio of hematopoietic cells to fat; ratio is 50-50

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2
Q

Bone marrow myeloid to erythroid ratio

A

Ratio 2=1 to 5=1

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3
Q

Define bone marrow trilineage hematopoiesis

A

Three lineages= granulocyte precursors, erythroid precursors, megakaryocytes.

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4
Q

Defined bone marrow left shift

A

Left shift I is a shift to immaturity—it may be reactive or neoplastic.

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5
Q

Normal value of plasma cells in the bone marrow

A

Less than 3%

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6
Q

Normal value of lymphocytes in bone marrow

A

Less than 20%

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7
Q

Normal value blast cells in the bone marrow

A

Less than 3%

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8
Q

Hemoglobin =

A

Heme + globin

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9
Q

Heme =

A

Iron + protoporphyrin

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10
Q

Hematocrit =

A

MCV × RBC

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11
Q

MCH =

A

Hemoglobin ÷ RBC

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12
Q

Indicates the major forms of hemoglobin and their chain composition

A

Hemoglobin A: α2, β2

Hemoglobin A 2: α2,

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13
Q

Indicate the variant forms of hemoglobin and the chain composition

A

Hemoglobin H: 4 beta chains
Hemoglobin Barts: 4 gamma chains
Hemoglobin Portland: 2 gamma chains + 2 delta chains

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14
Q

Normal hemoglobin: male, female

A

Male: 14 –18 grams per deciliter; Female: 12 – 16 grams per deciliter

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15
Q

Normal hematocrit: male, female

A

Male: 40% – 54%; Female: 35% – 47%

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16
Q

Normal red blood cell count: male, female

A

Mail: 4.5 – 6 x 10^6 per microliter

E-mail: 4 –5.5 × 10 ^ 6 per microliter

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17
Q

Normal reticulocytes

A

0.5%–2.5%

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18
Q

RBC: MCV

A

82 – 100 cubic micrometers

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19
Q

RBC: MCH

A

27 – 34 picograms

20
Q

RBC: MCHC

A

32% – 36%

21
Q

WBC: absolute count

A

4000 – 11,000

22
Q

WBC differential: absolute neutrophils count (ANC), (%)

A

ANC: 1800 –7000, (50 to 60%)

23
Q

WBC differential: neutrophils bands count (%)

A

Bands: 0 – 700,(2% – 4%)

24
Q

WBC differential: lymphocyte count (%)

A

1500 – 4000,(30% – 40%)

25
Q

WBC differential: monocyte count (%)

A

0 – 800,(1% – 9%)

26
Q

WBC differential: basophil count (%)

A

0 – 200,(0% – 1%)

27
Q

WBC differential: eosinophil count (%)

A

0 – 450,(0% – 3%)

28
Q

Normal platelet count:

A

150,000 – 400,000 per microliter

29
Q

MCHC =

A

Hemoglobin ÷ Hematocrit

30
Q

Definition of anemia

A

Reduction in circulating RBC mass

31
Q

3 surrogate markers of anemia

A

Red blood cell count, hemoglobin, hematocrit

32
Q

Anemia: critical criteria

A

Men: hemoglobin < 13.5,
Women: hemoglobin < 12.5

33
Q

Microcytic anemia: definition, etiology

A

MCV < 80; Iron deficiency, thalassemia, sideroblastic, chronic disease (later); “puny tics”

34
Q

Macrocytic anemia: definition, etiology

A

MCV > 100; Nutritional efficiency, alcohol, liver disease, hypothyroidism, reticulocytosis, bone marrow disease

35
Q

Normocytic anemia: definition, etiology

A

MCV = 80 – 100; chronic disease, kidney disease, acute blood loss

36
Q

Polycythemia Vera: definition

A

Increased red blood cell count; hematocrit > 54% in men, hematocrit > 47% in women

37
Q

Normal transferrin saturation (TSAT)

A

33%

38
Q

Corrected reticulocyte count =

A

Reticulocyte count × Hct/45

39
Q

Corrected reticulocyte count > 3%

A

Bone marrow responding adequately; RBC are being destroyed peripherally

40
Q

Corrected reticulocyte count <3%

A

Bone marrow is not responding adequately; RBC are being underproduced

41
Q

Osmotic fragility test (OSF)

A

Diagnostic test for hereditary spherocytosis; spherocytes will demonstrate membrane fragility in a hypotonic solution

42
Q

Sucrose test (RBC)

A

Screening test for paroxysmal nocturnal hemoglobinuria (PNH)

43
Q

Acidified serum test or flow cytometry for CD55 (RBC)

A

Confirmatory test for paroxysmal nocturnal hemoglobinuria (PNH)

44
Q

Heinz staining test

A

Screening test for G6PD deficiency

45
Q

Coombs test: direct and indirect

A

Coombs test also know as anti-globulin test. Diagnostic test for immune hemolytic anemia. Direct: test RBC for antibody or complement attachment; Indirect: test for antibody in serum

46
Q

Monospot test

A

Screening test for infectious mononucleosis caused by EBV. Also called heterophile antibody test.

47
Q

Monospot test interpretation

A

Positive test: EBV mononucleosis; Negative test: mononucleosis caused by another virus i.e. CMV.

Pathology (3 decks)

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