Unit 2 Enzymes Flashcards
Glucokinase I/G ratio change synthesis
Yes, insulin ^
Glucokinase pathway
Sugar trap
Glucokinase activity- add’l notes
High Km, low Vmax- fast w/low affinity
Hexokinase pathway
Sugar trap
Hexokinase- I/G ratio change synthesis?
Yes, insulin ^
Hexokinase activity notes
Inhibited by G-6-P
Low Km, low Vmax
Phosphofructokinase-1 pathway
Glycolysis
PFK-1 allosteric activators
AMP
Fructose 2,6-bisphosphate
PFK-1 allosteric inhibitors
ATP, citrate
PFK-1 synthesis changes by I/G ratio?
Yes, insulin ^
PFK-1 other notes (2)
**Rate limiting
ATP consuming
PFK-1 reciprocal regulation
FBPase-1
Pyruvate kinase pathway
Glycolysis
Pyruvate kinase allosteric activators
Fructose 1,6-bisphosphate
feed forward
Pyruvate kinase synthesis change w/ I/G ratio?
Yes, insulin ^