Unit 2 Enzymes Flashcards

0
Q

Glucokinase I/G ratio change synthesis

A

Yes, insulin ^

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Glucokinase pathway

A

Sugar trap

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Glucokinase activity- add’l notes

A

High Km, low Vmax- fast w/low affinity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Hexokinase pathway

A

Sugar trap

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Hexokinase- I/G ratio change synthesis?

A

Yes, insulin ^

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Hexokinase activity notes

A

Inhibited by G-6-P

Low Km, low Vmax

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Phosphofructokinase-1 pathway

A

Glycolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

PFK-1 allosteric activators

A

AMP

Fructose 2,6-bisphosphate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

PFK-1 allosteric inhibitors

A

ATP, citrate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

PFK-1 synthesis changes by I/G ratio?

A

Yes, insulin ^

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

PFK-1 other notes (2)

A

**Rate limiting

ATP consuming

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

PFK-1 reciprocal regulation

A

FBPase-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Pyruvate kinase pathway

A

Glycolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Pyruvate kinase allosteric activators

A

Fructose 1,6-bisphosphate

feed forward

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Pyruvate kinase synthesis change w/ I/G ratio?

A

Yes, insulin ^

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Pyruvate kinase: I/G ratio changes phosphorylation?

and how?

A

Yes
Insulin ^ dephosph ^
Glucagon/Epi ^ phosph ^

16
Q

Pyruvate kinase & energy

A

ATP generating

17
Q

Lactate dehydrogenase: pathway

A

Glycolysis/ anaerobic glycolysis

18
Q

Pyruvate carboxylase: pathway

A

Gluconeogenesis

19
Q

Pyruvate carboxylase allosteric activator

A

Acetyl CoA

20
Q

Pyruvate carboxylase requires ___ for coenzyme act.?

A

Biotin

21
Q

PFK-1 rxn?

A

Fructose-6-phosphate –> F 1,6 BisP

22
Q

PDHC inhibitors

A

Acetyl CoA and NADH

23
Q

PEP carboxykinase: pathway

A

Gluconeogenesis

24
Q

Lactate dehydrogenase rxn?

A

Pyruvate –> Lactate

anaerobic glycolysis in cytosol

25
Q

Pyruvate dehydrogenase rxn?

A

Pyruvate –> Acetyl CoA

in mitochondria

26
Q

Pyruvate carboxylase rxn?

A

Pyruvate –> Oxaloacetate (OAA)

in mitochondria

27
Q

PEP carboxylase: I/G change synthesis?

A

Yes, glucagon ^