unit 2 Flashcards
Disease
A condition of abnormal function involving any structure, part, or system
Syndrome
A group of signs and symptoms that occur together and are typical of a particular disorder/disease
Symptoms associated with sedentary living
- decreased fitness
- decreased bone density
- decrease HDL cholesterol
- increased blood sugar
- increased resting heart rate
- overweight/obese
Risk factor
A factor that cause a person or group of people to be at risk of an unwanted or unhealthful event
ex. no seatbelt –> raises risk of mortality if involved in car accident
Relative risk
Chance that a disease or side effect will occur given certain conditions or factors
ex. people who do not wear a seatbelt increase their risk of crash related injuries and deaths by 50%
Primary prevention
The preventions of risk factors.
- maintain health status, prevent new conditions
ex. Help UI students stay active
Secondary prevention
Prevention of disease once risk factors are present.
- detect/treat risk factors
ex. BP screen to identify who has high BP, recommended PA to decrease high BP
Tertiary prevention
Reduction in the amount of disability caused by disease; treatment or rehabilitation of disease.
ex. cardiac rehabilitation
Active couch potatoe
Someone who meets the PA guidelines
- sedentary rest of the day
Negative outcomes of higher levels of sedentary time
- increased waist circumference
- unhealthy levels of blood glucose, insulin, and fat
- lower measures of physical functioning
- increased risk of all cause mortality
Cardiovascular disease
Group of disorders of the heart and blood vessels
ex. coronary heart disease (heart attack), cerebrovascular disease (brain - stroke), hypertension, peripheral vascular disease (limbs)
Cardiovascular disease annual cost; cancer annual cost
475 billion; 228 billion
Atherosclerosis
Plaque buildup in arteries
Arteriosclerosis
hardening of arteries
Cardiovascular disease risk factor: modifiable and non-modifiable
Modifiable:
- tobacco
- obesity
- hypertension
- dyslipidemia
- diabetes
- metabolic syndrome
- elevated inflammatory biomarkers (reactive protein)
- indicative of systemic inflammation
- PA
Non-modifiable:
- age ( >45 men, >55 women)
- family history
- gender (male)
- ethnicity/race (AA)
Hypertension
Consistently high BP
- high >140/90 mmHg
- prehypertensive 120-139 / 80-89 mmHg
“White coat syndrome”
when BP is high at doctor; related to high BP at other times
How does PA lower BP
immediately lowers systolic and diastolic BP especially with multiple bouts of PA throughout day
Dylipidemia
High cholesterol (lipids) and fats (triglycerides) in blood
How does PA lower Dylipidemia
lowers triglycerides and LDL, increase HDL (not always)
What leaves you at an increased risk of Dylipidemia
Total cholesterol >200 mg/dL
HDL <40 mg/dL
LDL > 140 mg/dL
Triglycerides > 150 mg/dL
Diabetes
Inability to regulate blood glucose levels
Insulin
Allows glucose to cross cell membranes
Insulin sensitivity
How likely a cell is to respond to insulin
Insulin resistance
Cell of body do not respond to insulin thats present; need more insulin to cause a response
Type 1 diabetes
Insulin dependent
Type 2 Diabetes
non insulin dependent
- lifestyle disease; directly related to PA; related to visceral obesity
visceral obesity
Adipose tissue around organs (abdominal obesity)
Diabetes treatment
- Drugs: increase insulin sensitivity, increase insulin in body
- Weight loss to promote loss of abdominal fat
- CV exercise: may make cells more permeable to glucose
- Resistance training to increase insulin sensitivity and control glucose homeostasis
Metabolic Syndrome
Increases likelihood of CVD and diabetes; you have it if you have 3/5 symptoms:
- high waist circumference (>40 men, >35 women)
- Blood triglycerides (>150)
- Low blood HDL cholesterol
a. <40 men, <50 women - BP >130/85
- fasting blood glucose >110
How does PA decrease CVD disease
Regular PA participation…
- Increases hearts “fitness” coronary circulation
- increases EE
- decreases inflammatory response in body
- decreases coagulants in blood
- decreases insulin resistance
- enhances blood lipid profile
- regulates BP
How much PA to reduce CVD?
Meeting PA guidelines: 150 minutes moderate / 75 minutes vigorous (or combo)
- preliminary research of benefits from
- 2 min light/moderate intensity activity breaks every 20-30 min.
- this improved blood glucose and insulin levels as compared with controls (no activity breaks over 5 hr period)
cancer
Disease process associated with uncontrolled abnormal cell growth
cancer causes: internal and external
Internal:
- heredity
- immune dysfunction
- abnormal metabolism
External:
- behaviors / environments
Can be and interaction of both (environment / genetics)
Risks of cancer: modifiable and nonmodifiable
Modifiable:
- physical inactivity
- obesity
- tobacco use
- poor nutrient intake
- excessive sun exposure
- toxic environmental exposure
Non-modifiable:
- age, genetics, sex
Physical activity decreases cancer, how?
The most active person has a lower risk of cancer (dose response)
Evidence –> strongest link with colon and breast cancer; emerging link with lung and endometrial cancer
Starting PA at any point in life has benefits
PA decreases colon cancer by how much?
21-24%
PA decreases breast cancer by how much?
25-30% lower risk
How does PA reduce cancer?
- lowers sex hormones
- Directly: exercise decreases estrogens and androgens because fat tissue produces estrogens
- Indirectly: less fat tissue - Reduces insulin resistance
- insulin enhances cell proliferation, immediate and chronic - lowers systemic inflammation
- reduced colon transit time
- improves immune function `
How much PA to prevent, reduce risk, and treat cancer?
Evidence is still being developed
- 150 min. moderate / 75 min. vigorous aerobic PA / week and resistance training 2x / week
May have benefits at lower levels of PA
Depression
Difficulty concentrating, loss of interest, hopelessness, insomnia
Anxiety
Nervousness, uneasiness, apprehension
Psychological distress
stress in life / lack of wellbeing
How much of the population is affected by mental health condition
26%
Mood disorders
Depression, anxiety, psychological distress, age related decline in cognitive function, low self esteem, eating disorders
Mental health conditions are costly, effect work productivity, relationships and healthcare
Risk factors for mental disorders: modifiable and nonmodifiable
Modifiable:
- physical inactivity
- substance abuse
- low self - esteem
- distress (cant cope with stressors)
- negative lifestyle behaviors
Non-modifiable:
- age (younger), sex (W), genetics, trauma, chronic medical condition
PA as a treatment for mental health conditions: types
- Monotherapy
- using PA as the ONLY treatment - Augmented therapy
- using PA as addition to other treatments - Adjunct therapy
- PA may promote other benefits than those related to condition (depression / anxiety)
Exercise decreases the risk of…
- anxiety symptoms
- anxiety disorders
- depressive symptoms
- major depressive disorder
- age related decline in cognitive function
Possible mechanisms by which PA can benefit mental health: physiological
- cerebral capillary growth
- brain blood flow
- oxygenation
- increase regulation of neurotransmitters
- increase growth in brain cells
- increase ability of nerves to conduct impulses
Possible mechanisms by which PA can benefit mental health: psychological
- increase self esteem –> fitness and biomechical improvements
- improvements in motor skills –> more PA options and confidence
PA and mental health conditions
- PA is not shown to be effective as the only treatment method for mental heath conditions
- PA is recommended as adjunct therapy
- Recommended 30-60 min. 3-5 days/week (aerobic or RT)
- Consistent with PA guidelines for Americans
Osteoporosis
- Low bone mass
- Structural deterioration of bone tissue
- Contributes to bone fracture (hip, vertebrae, wrist)
- Painful
contribute negatively to functional health
Osteoarthritis
- Joint pain and dysfunction
- costly (productivity/medical costs)
- Loss of articular cartilage –> bone rubbing bone
- May result in surgery / joint replacement
contribute negatively to functional health
Sarcopenia
Loss of muscle mass; contribute negatively to functional health
Not related to a specific disease process; determinant of functional health
Osteoporosis risk factors: Modifiable and non-modifiable
Modifiable:
- physical inactivity
- tobacco use
- thin / underweight
- loss of sex hormones / estrogens / testosterones
- nutrition (alc., low calcium, vitamin D levels, caffeine)
Non-modifiable:
- age, sex, genetics, ethnicity/race, history of fractures
PA decrease risk of osteoporosis, how?
- increase peak bone mass
- slows decline in bone mass
- reduces risk of falls
What type of PA should one do to decrease risk of osteoporosis?
- high intensity, weight bearing
- resistance training, jumping, running
Osteoarthritis risk factors
- Physical inactivity
- excessive PA or overuse (occupational loads)
- excessive body weight
- age, sex, genetics, history of joint injury
Does jogging reduce risk of Osteoarthritis?
no
Low muscle mass (Sarcopenia) risk factors?
physical inactivity, tobacco use, age, sex (W), genetics
Functional health
Ability to do the PA one wants to do without pain or limitation
Functional health: ADL
Activity of daily living
Functional health is negative affected by:
- Low musculoskeletal health (low mass and poor muscle function)
- Low aerobic capacity, poor balance, lack of social support/networks
- contributes to falls
How to lower the risk of falls
- Balance training and muscle strengthening
- 3x/wk for 30 min
- backwards walking, sideways walking, heel walking, toe walking, sit to stand
- supported progressing to non-supported
PA and musculoskeletal health
- Inverse relationship between PA/exercise and risk of fractures
- activity 36-68% lower risk of hip fractures - Regular PA able to increase bone density 1-2%
- No direct evidence that moderate PA increases arthritis
Protective benefits of PA and musculoskeletal health
- decrease in pain
- increase function
- increase QOL and mental health
- aerobic PA may slow the rate of loss of muscle mass
Obesity and overweight: significant changes over the last 40 yrs
- obese in 1980 - 15%
- obese in 2010 - 33.8%
Obesity and overweight: obesity today
- very common and hard to treat and even harder to prevent