Unit 2

Question 1

FAS 1
FAS 2

Answer 1

vertebrates (multifunctional enzyme)
plants and bacteria (in dissociated form)

Question 2

FAS 1 seven domains

Answer 2

KS MAT DH ER KR ACP TE

Question 3

PLANTS
Fatty acid oxidation
Fatty acid biosynthesis

Answer 3

peroxisomes
chloroplast (coz NADPH is produced by light rection in chloroplast stroma)

Question 4

Production of NADPH

Answer 4

1- Malic enzyme (malate to pyruvate)
2- Pentose Phosphate Pathway (glu6p to ribulose5p)

Question 5

compounds which can cross mitochondrial membrane

Answer 5

Citrate
Malate
Pyruvate

Question 6

Acetyl CoA Carboxylase

Answer 6

Convert acetyl coa into malonyl coa
palmitate -ve
citrate +ve
phosphorylation -ve
dephosphorylation +ve

Question 7

unsaturation reaction of FA

Answer 7

Fatty acyl coa desaturase
in SER

Question 8

Precursor of Prostaglandin

Answer 8

Linoleic acid

Question 9

Plant desaturase can’t work on

Answer 9

Free FA , only work when they are esterified (usually phospholipids)

Question 10

Effect of insulin of FA Biosynthesis

Answer 10

+ve

Question 11

diabetic patients

Answer 11

insulin not there so acetyl coa is shunted to ketone body production; ketosis

Question 12

Triacylglycerol cycle

Answer 12

Adipose tissue and Liver
75% TG are re-esterified back

Question 13

Thiazolidinedione

Answer 13

Induces expression of PEPCK in adipose tissue

Question 14

Stratergy 1 and 2 for biosynthesis of phospholipids

Answer 14

1- phosphatidic acid gets activated
2- head group gets activated

euk- both
pro- only 1