UNIT 1 Flashcards
Anatomy of the Hematologic System
Blood: A connective tissue consisting of plasma (the liquid component) and formed elements (cells and cell fragments).
Blood Vessels: Includes arteries, veins, and capillaries, which transport blood throughout the body.
Bone Marrow: The primary site for hematopoiesis (blood cell production). It is located in the medullary cavities of bones.
Spleen: Filters blood, removes old or damaged blood cells, and plays a role in immune response.
Liver: Produces clotting factors and helps in the breakdown of old red blood cells.
Lymphatic System: Includes lymph nodes and lymphatic vessels that play a role in immune response and fluid balance.
Physiology of the Hematologic System:
Hematopoiesis: The process of blood cell production, including red blood cells (erythrocytes), white blood cells (leukocytes), and platelets (thrombocytes). It occurs primarily in the bone marrow.
Red Blood Cells (RBCs): Carry oxygen from the lungs to tissues and carbon dioxide from tissues to the lungs. They contain hemoglobin.
White Blood Cells (WBCs): Part of the immune system; they protect the body against infection and foreign substances.
Platelets: Play a crucial role in blood clotting and wound repair.
Plasma: The liquid portion of blood that carries cells, hormones, nutrients, and waste products.
Assessment of Patients with Hematologic Disorders
- Patient History:
Symptoms: Assess for fatigue, pallor, bleeding tendencies, bruising, pain, or swelling.
Medical History: Include past illnesses, surgeries, or conditions affecting blood cell production.
Family History: Inquire about hereditary blood disorders or conditions.
- Physical Examination:
Skin and Mucous Membranes: Check for pallor, jaundice, or petechiae (small red or purple spots).
Lymph Nodes: Palpate for swelling or tenderness, indicating possible lymphoma or infection.
Spleen and Liver: Assess for enlargement (hepatosplenomegaly).
Joints: Examine for swelling or pain related to bleeding disorders.
Anemia
Anemia is ‘‘ Decrease in number of red blood cells (RBCs) or less than the normal quantity of Hemoglobin in the blood.
WHO Grading of Anemia
❖Grade 1 (Mild Anemia): 10 g/dl
❖Grade 2 (Moderate Anemia): 7-10 g/dl
❖Grade 3 (Severe Anemia): below 7 g/dl
Classification
❑On The Basis of Cause
A. Hypo proliferative (Resulting From Defective RBC Production)
B. Haemorrhagic (Resulting from RBC Loss)
C. Haemolytic Anaemia (Resulting From RBC Destruction)
❑ On the Basis of Morphology
A. Microcytic Anemia (Cells are smaller than normal under 80 fl)
B. Macrocytic Anaemia (cells are larger than normal over 100 fl)
C. Normocytic Anaemia (Cells are normal size 80–100 fl)
1.Microcytic Anemia
1.Microcytic Anaemia
It Occurs in Iron Deficiency Anaemia and Ineffective RBC Production a result of Haemoglobin synthesis failure/insufficiency.
▪Cells are smaller than normal under 80 fl Heme synthesis defect
- Iron Deficiency Anaemia
▪Globin Deficiency Defect
- Thalassemia
- Macrocytic Anaemia
▪An Abnormally Large RBC, cells are larger than normal over 100 fl
▪ It Occurs as Nutritional Deficiency. E.g.Vit.B12 , Folates and Protein
▪It’s also occurs due to Drug toxicity (phenytoin), Liver Disease, Alcolism, Hypothyrodism,
Chronic Haemolytic Anaemia , Leukemia &Gastric Bypass surgery
- Normocytic Anaemia
▪Overall Haemoglobin levels are decreased but the red blood cell size(MCV)
remains normal.
▪Cells are normal size 80–100 fl
Causes
➢Acute blood loss
➢ Haemolytic Anaemia
➢ Aplastic Anaemia
CAUSES OF ANEMIA
-increased requirements
menstruating females
pregnancy
lactation
growing infants and children
erythropoietin treatment
-increased loss
GI bleeding
menorrhagia
persistent hematuria
intravascular hemolytic anemias
regular blood donors
parasitic infections
-decreased intake
vegetarian diet
socioeconomic factors
-decreased absorption
upper GI pathology(celiac disease and Crohn disease )
gastrectomy
medications ( antacids, zantac )
causes continue… ANEMIA
impaired rbc production ( deficiency of nutrition e.g., iron, vitamin B12 , vitamin B6, decreased erythropoietin production
increased destruction of RBC z9 hemolytic ( abnormal hemoglobin synthesis ( thalassemia )
enzymatic defect ( glucose- 6 phosphate deficiency
infection ( malaria)
antibody reaction ( RH or ABO iso immunizations
poisoning ( lead poisoning )
burns
splenomegaly
idiopathic
hereditary spherocytosis
*Due to Increased Blood Loss(Haemorrhagic) -Acute (Trauma,Epistaxis,Scurvy,Hemophilia etc.) -Chronic(Chronic Dysentry,Bleeding Piles,Haemorrhage etc.)
*Decreased RBC Production(Bone Marrow Depression)
- Hypoplasia ,Chronic Illness (Leukaemia & Nephritis)
- TB , Neoplastic Disease , Liver Disease
- Hypothyrodism
PATHOPHYSIOLOGY OF ANEMIA
decrease in RBCs, HB, or HCT
diminished o2 carrying capacity
hypoxia and hypoxia induced effects on organ function
signs and symptoms of anemia
‘‘Anemia occurs when there is a decrease in red blood cells (RBCs), hemoglobin (Hb), or hematocrit (Hct), leading to a reduced oxygen-carrying capacity in the blood. This diminished oxygen supply causes tissue hypoxia, which can impair the function of various organs. A reduction in RBCs, hemoglobin, or hematocrit can result from factors such as blood loss, destruction of RBCs (hemolysis), or decreased production in the bone marrow. As oxygen delivery to tissues declines, symptoms like fatigue, weakness, dizziness, and shortness of breath arise. Organs struggle to function properly without sufficient oxygen, contributing to further symptoms like pallor, increased heart rate, and difficulty breathing
SIGN AND SYMTPOMS
➢Brittle nails
➢Koilonychia (spoon shaped nails)
➢Atrophy of the papillae of the tongue
➢Angular Stomatitis
➢Brittle hair
➢Dysphagia and Glossitis
➢Plummer Vinson Syndrome /Kelly Patterson Syndrome ( Dysphagia with
Iron Deficiency Anemia)
INVESTIGATIONS
CBC ( Hb, hematocrit, rbc, mcv )
stool hemoglobin test
peripheral blood smear
iron levels
ferritin
folate
vitamin B12
bilirubin
lead level
hemoglobin
reticulocyte count
LFT ( liver function test )
RFT ( renal function test )
bone marrow biopsy
Iron deficiency anemia
➢Anemia associated with either Inadequate Absorption or Excessive Loss of Iron/Blood.
➢It is Chronic Microcytic Anemia.
➢The most common Cause of Anemia in Children is Iron Deficiency Anemia.
➢It’s most common cause by Microcytic Hypochromic Anemia.
Causes of iron deficiency anemia
➢Insufficient Iron Supply at Birth
➢Impaired Iron Absorption
➢Blood Loss
➢Insufficient Iron Intake in Diet
➢Periods of Rapid Growth