Uncommon Blood groups Flashcards
What immunoglobulin class do most Diego antibodies belong to?
IgG
IgM antibodies have also been identified.
What is the prevalence of the Yt antigens in the Cartwright blood group system?
Yta - high frequency (99.8%), Ytb - low frequency (8%)
Three phenotypes are Yt(a+b-) = 91.9%, Yt(a+b+) = 7.8%, Yt(a-b+) = 0.3%.
What is the clinical significance of anti-Wra in the Diego blood group system?
Implicated in severe hemolytic transfusion reactions (HTRs)
Anti-Wra generally detected in AHG phase.
What are the two antigens in the Scianna system?
Sc1 (high frequency) and Sc2 (low frequency)
Anti-Sc1 appears to be immune in origin while Sc2 may be naturally occurring.
What is the incidence of the Coa and Cob antigens in the Colton blood group system?
Coa - high incidence (99.9%), Cob - low incidence (10%)
Co3 found on all RBCs except those of phenotype Co(a-b-).
What is the immunoglobulin class of the antibodies in the Chido/Rodgers system?
IgG
Anti-Ch and anti-Rg have not been associated with RBC transfusion reactions.
What is the significance of the Sda antigen in the Sda blood group system?
Approximately 91% of the population is Sda positive
Anti-Sda agglutinates in the presence of Sda positive cells.
What is the Bg blood group system commonly referred to as?
White cell antibody
Not considered clinically significant but may mask clinically significant antibodies.
What is the significance of the Knops blood group system antigens?
Generally IgG and react in IAT phase, considered clinically insignificant
Anti-Kna is frequently seen in multiply transfused patients.
Fill in the blank: The Diego blood group system is characterized by _______ incidence antigens.
high and low
True or False: The Dombrock antigens are sensitive to treatment with DTT.
True
What is the prevalence of the Yt(a-b-) phenotype in the Cartwright blood group system?
0.3%
What is the significance of anti-Co3 in the Colton blood group system?
Reacts with all Co(+) and Co(b+) cells
Implicated in mild HTRs and severe HDFN.
