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Breast > UCLA Harbor Review Breast Disease > Flashcards

UCLA Harbor Review Breast Disease Flashcards

General Breast Disease

1
Q

What is Mondor disease of the breast?

A

Superficial anterior chest wall vein thrombophlebitis.

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2
Q

What is the eponym for superficial anterior chest wall thrombophlebitis?

A

Mondor disease of the breast

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3
Q

How is Mondor disease of the breast treated?

A

Warm compresses and NSAIDs

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4
Q

What is the etiology for Mondor disease of the breast?

A

Etiology unclear. Consider Virchow’s triad: injury, stasis, hypercoaguability.

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5
Q

What is Virchow’s triad?

A

Injury, stasis, hypercoaguability.

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6
Q

What are the usual sites for Mondor disease of the breast?

A

3 veins: lateral thoracic vein, thoracoepigastric vein, superficial epigastric vein.

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7
Q

On mammography, describe what a radial scar looks like.

A

Long, thin radiating spicules with translucent central area of fat. AKA: Black Star.

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8
Q

Are radial scars on mammography and histology benign lesions?

A

Yes

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9
Q

Do radial scars have a risk of progression to malignancy?

A

Yes

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10
Q

What is the time frame to when breast cancer develops after the diagnosis of LCIS?

A

15 years

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11
Q

LCIS increases the risk of what type of cancer?

A

Invasive ductal carcinoma

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12
Q

Does LCIS in one breast increase the risk of breast cancer in the contralateral breast?

A

Yes

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13
Q

What are the management options for LCIS?

A
  1. Close clinical follow-up
  2. Tamoxifen
  3. Bilateral mastectomies
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14
Q

What is the difference in pathology in women with BRCA1 vs BRCA2 mutations?

A

BRCA1: More poorly differentiated and hormone receptor -
BRCA2: Well-differentiated and hormone receptor +

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15
Q

What BRCA mutation increases the risk of prostate cancer?

A

Both BRCA1 and BRCA2

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16
Q

What other cancers are associated with BRCA2?

A

Melanoma, pancrease, stomach, gallbladder and bile duct

17
Q

What % of all breast cancers are due to hereditary genes?

A

5-10%

18
Q

What % of all male breast cancers are due to hereditary genes?

A

40%

19
Q

What is the lifetime risk of breast cancer in women with BRCA1 and BRCA2?

A

Both carry an 80-90% risk.

20
Q

By age 40, in women with BRCA1 or BRCA2, what % will have breast cancer?

A

BRCA1 18%

BRCA2 15%

21
Q

What is the lifetime of breast cancer in men with BRCA1 and BRCA2?

A

BRCA1 1%

BRCA2 6%

22
Q

What is the lifetime risk of ovarian cancer in women with BRCA and BRCA2 mutations?

A

BRCA1: 40%
BRCA2: 19%

23
Q

What chromosomes do BRCA1 and BRCA2 map to?

A

BRCA1: 17p21
BRCA2: 13

24
Q

Do bilateral prophylactic simple mastectomies completely eliminate the risk of breast cancer?

A

No. It decreases the risk by 90%.

Breast (2 decks)

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