UCLA Harbor Review Breast Disease Flashcards
General Breast Disease
What is Mondor disease of the breast?
Superficial anterior chest wall vein thrombophlebitis.
What is the eponym for superficial anterior chest wall thrombophlebitis?
Mondor disease of the breast
How is Mondor disease of the breast treated?
Warm compresses and NSAIDs
What is the etiology for Mondor disease of the breast?
Etiology unclear. Consider Virchow’s triad: injury, stasis, hypercoaguability.
What is Virchow’s triad?
Injury, stasis, hypercoaguability.
What are the usual sites for Mondor disease of the breast?
3 veins: lateral thoracic vein, thoracoepigastric vein, superficial epigastric vein.
On mammography, describe what a radial scar looks like.
Long, thin radiating spicules with translucent central area of fat. AKA: Black Star.
Are radial scars on mammography and histology benign lesions?
Yes
Do radial scars have a risk of progression to malignancy?
Yes
What is the time frame to when breast cancer develops after the diagnosis of LCIS?
15 years
LCIS increases the risk of what type of cancer?
Invasive ductal carcinoma
Does LCIS in one breast increase the risk of breast cancer in the contralateral breast?
Yes
What are the management options for LCIS?
- Close clinical follow-up
- Tamoxifen
- Bilateral mastectomies
What is the difference in pathology in women with BRCA1 vs BRCA2 mutations?
BRCA1: More poorly differentiated and hormone receptor -
BRCA2: Well-differentiated and hormone receptor +
What BRCA mutation increases the risk of prostate cancer?
Both BRCA1 and BRCA2
What other cancers are associated with BRCA2?
Melanoma, pancrease, stomach, gallbladder and bile duct
What % of all breast cancers are due to hereditary genes?
5-10%
What % of all male breast cancers are due to hereditary genes?
40%
What is the lifetime risk of breast cancer in women with BRCA1 and BRCA2?
Both carry an 80-90% risk.
By age 40, in women with BRCA1 or BRCA2, what % will have breast cancer?
BRCA1 18%
BRCA2 15%
What is the lifetime of breast cancer in men with BRCA1 and BRCA2?
BRCA1 1%
BRCA2 6%
What is the lifetime risk of ovarian cancer in women with BRCA and BRCA2 mutations?
BRCA1: 40%
BRCA2: 19%
What chromosomes do BRCA1 and BRCA2 map to?
BRCA1: 17p21
BRCA2: 13
Do bilateral prophylactic simple mastectomies completely eliminate the risk of breast cancer?
No. It decreases the risk by 90%.
