Types of Proto-oncogenes, effect when oncogenic Flashcards
Types of Proto-oncogenes
Growth Factor
Growth Factor Receptors
Intracellular Pathway
Transcription Factors
What are Growth Factors
GF are peptides that are secreted into the ECM that activate growth promoting cascades.
Growth Factors in an oncogenic state…
May allow expression of absent receptors, over-expression of normal receptors and some may respond without GF even being present.
What are Growth Factor Receptors
GF Receptors transmit GF info into the target. Their binding leads to cell proliferation.
Growth Factor Receptors in an oncogenic state…
May be over-expression of the receptors and some may respond without GF. All of the create excessive response.
Cytoplasmic signalling pathways in an oncogenic state…
may manufacture excessive or abnormal components of intracellular growth cascades. They may signal with no receptor input at all. Ras protein is an example of this in which mutations cause persistent activity.
What are transcription factors
Proteins that normally trigger cell to enter S phase.
Transcription factors in an oncogenic state…
may cause over production or loss of transcription factor regulation. Cell will keep multiplying and will skip double check points in the cycle.
