Types of DNA Damage and Mechanism of Repair Flashcards
1
Q
Nicks in DNA strand
A
repaired by DNA ligase
2
Q
Chemically modified base
A
Base excision (removal by base-specific DNA glycoysis)
3
Q
Mismatched bases
A
Corrected by mismatched repair (excision and resynthesis)
4
Q
Apurinic or apyrimidinic site
A
fixed by enonuclease repair system
5
Q
Damaged region of DNA
A
Nucleotide excision repair (excision and repair across partner strand)
6
Q
Pyrimidine dimers (from UV light)
A
Enzymatically reversed
7
Q
Damaged region of DNA
A
DNA damage bypass (sequence in damaged region recovered via recombination)