type of sensitivities

Question 1

type 1 anaphylactic sensitivity mechanism ?

Answer 1

Antigen reacts with IgE bound to mast cells

Question 2

examples of Type I - Anaphylactic shock ?

Answer 2

Anaphylaxis
* Atopy (e.g. asthma, eczema and hayfever)

Question 3

what is type Type II - Cell bound?

Answer 3

IgG or IgM binds to antigen on cell surface

Question 4

examples of what is type Type II - Cell bound?

Answer 4

Autoimmune haemolytic anaemia
HIT (Heparin-induced thrombocytopaenia (HIT))
* ITP
* Goodpasture’s syndrome
* Pernicious anaemia
* Acute haemolytic transfusion reactions
* Rheumatic fever
* Pemphigus vulgaris / bullous pemphigoid

Question 5

what is Type III - Immune complex?

Answer 5

Free antigen and antibody (IgG, IgA) combine

Question 6

examples of type 3 ?

Answer 6

Serum sickness
* Systemic lupus erythematosus
* Post-streptococcal glomerulonephritis
* Extrinsic allergic alveolitis (especially acute phase)

Question 7

Type IV - Delayed hypersensitivity mechanism ?

Answer 7

T-cell mediated

Question 8

examples of Type IV - Delayed hypersensitivity mechanism ?

Answer 8

• Tuberculosis / tuberculin skin reaction
• Graft versus host disease
• Allergic contact dermatitis
• Scabies
• Extrinsic allergic alveolitis (especially chronic phase)
• Multiple sclerosis
• Guillain-Barre syndrome

Question 9

what is Type V?

Answer 9

Antibodies that recognise and bind to the cell surface receptors.

This either stimulating them or blocking ligand binding

Question 10

examples of Type V?

Answer 10

Graves’ disease
* Myasthenia gravis