Type 1 HSR Flashcards
HSR 1 also known as?
Anaphylactic or Immediate Hypersensitivity reaction
Most important cell goin to be required at the start of Stage 1 in HSR1?
T helper cell, subtype 2
Important cytokine involved in the release of IgE antibody
IL4
Which antibody increases at the time of type 1 HSR?
IgE
Which is the WBC that increases with the action of IL5?
Eosinophils
Which connective tissue has receptors for IgE antibodies?
Mast cells
True/False: At the sensitization stage of HSR1, The patient is asymptomatic.
True.
Most common antigen, in India, responsible for immune cell activation in HSR1 in Bronchial Asthma. How about in western countries?
House dust in India and Pollen in western countries.
Inflammatory chemicals responsible for the clinical symptoms in HSR1.
Histamine, Prostaglandins, and Leukotrienes
In the second stage, how does the mast cell get activated?
When the antigen forms and Ag-Ab complex on the surface of mast cells
What are the two inflammatory chemicals release by mast cells upon activation?
Histamine & Arachidonic acid (gives rise to prostaglandins and Leukotrienes)
Enzyme responsible for production of the two chemicals formed by Arachidonic acid
1) COX enzyme for AA ——- Prostaglandins
2) 5-LOX enzyme for AA——- Leukotrienes
What symptoms are produced by Histamine and Prostaglandins in HSR1?
Vasodilation and increased mucous secretion ——- Cough
What symptoms are produced due to Histamine and leukotrienes?
Bronchospasm —- dyspnea
How does penicillin cause HSR1?
Penicillin administration ———— Anaphylactic shock ————— inc. BP, laryngeal edema, dyspnea
Laryngeal edema - chokes the patient ——- death
