Type 1

Question 1

Type 1 Def

Answer 1

Absolute insulin deficiency

Question 2

Rapid acting

Answer 2

Lispro/Aspart/Glulisine: 5-15 min; duration 3-5 hrs

Regular : 30-60 min; 6-8+ hr

Question 3

Intermidate acting

Answer 3

NPH: 1-2 hrs; peak 6-10 hrs; duration 12+ hrs

Question 4

Long acting

Answer 4

Detemir : 1 hr; flat; 12-24 hrs

Glargline: 1.5 hr; flat ; 24 hrs

Question 5

Why is glargline long acting

Answer 5

1. Injection of an acidic solution (pH 4)
2. Precipitation of glargine in SQ tissue (pH 7.4)
3. Slow dissolution of free glargine hexamers from precipitated glargine (stabilized aggregates)
   * *hexamers to dimers to monomers
4. Prolonged action