Tutorials 5 - 8 - Breast, Bladder, Lung, Lymphoma Flashcards
Outline the breast screening programme
Women aged 47 - 73 - mammogram every 3 years
What sort of cancer does a density suggest?
Calcification?
Density - invasive
Calcification - DCIS
What sort of cancer is most common in the breast?
Adenocarcinoma
What is DCIS?
Ductal carcinoma in situ
Limited to ducts and lobules by BM
What is Paget’s disease?
Malignant cells spread to nipple skin without crossing BM
What is luminal A?
What is luminal B?
Basal-like?
A = ER +ve, her2 -ve B = ER +ve only Basal-like = ER -ve, PR -ve, her2 -ve
What is a germline mutation in p53 called?
Lee-Fraumeni syndrome
Where does breast cancer typically met to?
Bone, brain, lung, liver
Describe the triple approach to breast cancer diagnosis
- History and examination
- Imaging
- Biopsy
What sort of cancer affects the bladder?
Transitional cell carcinoma
Give 3 risk factors for bladder cancer apart from sex and age
- Smoking
- Exposure to dyes
- Kidney stones
How is bladder cancer diagnosed/treated?
TURBT - Transurethral resection of bladder tumour
What type of cancer affects the prostate?
Adenocarcinoma
How is prostate cancer graded?
Gleason grading system
What are the two major causes of lung cancer?
Smoking - polycyclical aromatic hydrocarbons
Asbestos