Tutorial 1: States Of Matter Flashcards
What properties to liquid crystals have?
Flow properties similar to liquid
Optical properties similar to solid
What are liquid crystals?
An intermediate state of matter with an ordered arrangement of atoms or molecules
How are liquid crystals described?
With having birefringence
What is birefrengence?
The ability to split light into 2 rays travelling at different speeds, directions and refractive indexes
What are three different structures and arrangements of crystals?
Lyotropic LC: long ranged orientational order achieved by the additions of a solvent
Thermotropic LC: occur within a certain temperature range
Metallotropic LC: contains metals
What is polarised light?
Light that travels in one single direction
What are the two filtering units of the polarised light microscope?
Polariser which is added to the optical pathway beneath the specimen. This filters the light
Analyser which is placed over the front of the lens objective in the body of the microscope
What happens to the polarised light if the sample displays biefrengence?
Some of the light will go through the molecule, one of the rays will be blocked by the analyser
What substance are isotropic?
Substances which do not display birefrengence e.g. Water, amorphous solid
What substances are anisotropic?
Substances which do display birefrengence e.g. Liquid crystals, crystalline solid
What is seen in an isotropic sample under a polarised microscope?
Light goes through sample without a change in direction will be blocked by the analyser, so you see a black background
What is seen in an anisotropic sample under a polarised microscope?
You see shininess with a dark background.
Dark background is due to the light being blocked by the analyser
The shininess is due to some light being able to pass through due to the sample displaying birefrengence
Why would some systems retain their optical properties when mixed with other components while other systems dont?
If the system is dissolved in the other component the optical properties will be lost as the system will no longer be liquid crystalline, however if a system is not dissolved and is suspended in the other component, its optical properties will be retained as it has not lost its crystalline structure
What are the benefits and disadvantages of choosing a crystalline solid as a dosage form for a drug?
+ drug is very stable
+ there is a sharp melting point
- harder to dissolve
- so harder to absorb
- cknsequently, lower bioavailability
What are the advantages and disadvantages of using an amorphous solid as a drug formulation?
+ easier to dissolve
+ easily absorbed
+ higher bioavailability
- less stable, has a variable melting point
What are the four different types of solid forms?
Polymorphs, amorphous, solvate, salt
What are the different kinds of particles that can constitute the different solid forms?
Active molecule Solvent molecule Acid Deprotonated molecule Protonated active molecule
What is crystalline arrangement?
Ordered arrangement of atoms or molecules
Often organised in Long range order and symmetrical
The compounds can have more than one crystalline arrangement, such compounds are called polymorphs
What is amorphous structure?
Structure of solids which have a random arrangement of atoms or molecules
This lacks long range order characteristic of crystals
What is the difference between liquids and liquid crystals?
Liquids have a random arrangement of atoms or molecules
Liquid crystals are an intermediate state of matter and have an ordered arrangement of atoms or molecules
They display flow properties similar to liquids
What is anisotropic property?
Where a substance displays differences in the optical properties of a material when measured along different axes
The substance has optical properties that vary with the orientation of incident light
They affect light differently in different directions
What are isotropic properties?
Where molecules of a substance are in random motion and orientation
The optical properties of the material is identical in all directions so no birefrengence is observed
What are some examples of anisotropic materials?
Cetrinide antiseptic
Cetostearyl alcohol
What are examples of isotropic substances?
Liquid paraffin in oil ohase
Water in aqueous phase,
Cod liver oil in oil phase