Tut Q's

Question 1

In regard to species variation in PKs/PDs, which of the following is not correct about animal deficiency in Phase II metabolism?

Answer 1

collie: P-glycoprotein absent.

Question 2

The two curves below were obtained from medicines X and Y. The ordinate (Y-axis) represents the percentage of animals responding to the beneficial effect of the medicine. Which of the following statements is most correct?

Answer 2

Medicine X is 30 times more potent than medicine Y.

Question 3

Which of the following medicines is a CYP inhibitor?

Answer 3

Ranitidine.

Question 4

Which of the following medicines is a CYP inducer?

Answer 4

Phenytoin.

Question 5

A dog that is maintained on phenobarbital for the control of epilepsy may not respond to antifungal therapy with griseofulvin. Which of the following is most correct about the mechanism of this medicine interaction?

Answer 5

Phenobarbital induces hepatic microsomal enzymes, increasing griseofulvin metabolism.

Question 6

The following factors contribute to effective distribution of medicines except:

Answer 6

High plasma protein binding ability.

Question 7

Of the alternatives below which best includes medicines and/or medicine classes that are classified as Schedule 8 (S8)?

Answer 7

Fentanyl and morphine.

Question 8

Which of the following statements about medicines and their interactions with regulatory receptors is most correct?

Answer 8

Medicine binding to receptors play an important role in the elimination of a drug.

Question 9

Which of the following medicine is a CYP inhibitor?

Answer 9

Both a and d.

Question 10

A pharmacodynamic interaction resulting in medicine antagonism may be caused by the concurrent administration of penicillins e.g. amoxicillin and:

Answer 10

Tetracyclines.

Question 11

Which of the following is NOT correct regarding pharmacodynamic interaction resulting in medicine antagonism, which is caused by the concurrent administration of H1 antihistamines and pilocarpine?

Answer 11

Pilocarpine increases the efficacy of H1 antihistamines leading to drug toxicity.

Question 12

Which of the following is NOT correct regarding examples of medicines combinations that would result in pharmaceutics interaction incompatibility?

Answer 12

Amphotericin B - sterile water.

Question 13

Which of the following statements is most correct about the role(s) of the APVMA (Australian Pesticides and Veterinary Medicines Authority) in vet medicine regulations?

Answer 13

APVMA approves product labels.

Question 14

Which of the following is NOT a requirement for a veterinary prescription?

Answer 14

Owner’s Medicare number.

Question 15

Which of the following statements about controlled (Schedule 8) medicines is NOT correct?

Answer 15

Controlled medicines must not be destroyed.

Question 16

Which is not a chemical mediator?

Answer 16

Cytochrome P450.

Question 17

Which is NOT a parenteral mode of drug administration?

Answer 17

oral

Question 18

Which of the following is TRUE?

Answer 18

Acidic drugs become ionized in an alkaline pH as per: [AH]⇌[A- ]+ [H+].

Question 19

Which of the following best describes ADME?

Answer 19

Absorption, distribution, metabolism, excretion.

Question 20

Which medicine should you NOT handle if you are pregnant or have asthma?

Answer 20

Prostaglandins.

Question 21

What medicine is NOT permitted in food production animals?

Answer 21

Enrofloxacin.

Question 22

Which of the following should NOT be given ivermectin?

Answer 22

Collies

Question 23

Which species of animal is deficient in glucuronidation?

Answer 23

feline

Question 24

What dose of paracetamol should you administer to achieve a plasma concentration of 5mg/L accounting for a volume of dispersion of 200L? (V= M/C, where V: volume distribution; M: amount; C: plasma concentration)

Answer 24

1000mg.

Question 25

Which of the following medications is suitable for use on cats?

Answer 25

Meloxicam.

Question 26

When using Xylazine in ruminants it is important to:

Answer 26

Use 1/10th of the recommended dose.

Question 27

Medicines which bind to regulatory receptors are often similar to:

Answer 27

Endogenous ligands.

Question 28

Which statement about the half-life of medicines is true?

Answer 28

It is shorter in ruminants and horses than it is in dogs and cats.

Question 29

What is the most accurate definition of pharmacodynamics?

Answer 29

The relationship between medicine dose and the response of the treated animal.