Tumour Markers

Question 1

What can tumour markers be divided into?

Answer 1

Monoclonal antibodies against carbohydrate or glycoprotein tumour antigens
Tumour antigens
Enzymes (ALP, neurone specific enolase)
Hormones (e.g. ADH, Calcitonin)

Question 2

Examples of monoclonal antibody tumour markers

Answer 2

CA 125
CA 19-9
CA 15-3

Question 3

What cancer is CA 125 seen in?

Answer 3

Ovarian cancer

Question 4

What cancer is CA 19-9 seen in?

Answer 4

Pancreatic cancer

Question 5

What cancer is CA 15-3 seen in?

Answer 5

Breast cancer

Question 6

Examples of tumour antigens

Answer 6

PSA 
AFP
CEA
S-100
Bombesin

Question 7

What does PSA stand for?

Answer 7

Prostate specific antigen

Question 8

What cancer is PSA raised in?

Answer 8

Prostate cancer

Question 9

What does AFP stand for?

Answer 9

Alpha-feto protein

Question 10

What cancer is AFP seen in?

Answer 10

Hepatocellular carcinoma (HCC)
Tertatoma

Question 11

What does CEA stand for?

Answer 11

Carcinoembryonic antigen

Question 12

What cancer is CEA seen in?

Answer 12

Colorectal cancer

Question 13

What cancer is S-100 seen in?

Answer 13

Melanoma

Schwannomas

Question 14

What cancer is Bombesin seen in?

Answer 14

Small cell lung carcinoma
Gastric cancer
Neuroblastoma