tumour markers Flashcards
what tumour markers are present in the following cancers:
- Myeloma
- non hodgekins lymphoma
- hepatocellular carcinoma-
- ovarian cancer?
myeloma:
- B2 microglobulin
- paraproteins
non-hodgekins lymphoma
- B2 macroglobulin
HCC:
- AFP
ovarian cancer
- Ca125
what tumour marker is raised in non-seminomatous germ cell tumours?
Alpha fetoprotein
also b-hCG
what tumour markers are present in the following cancers:
- GI cancer
- breast cancer
- lung cancer
- pancreatic cancer
GI cancer
- CEA (esp if liver mets) - CA19-9 - sometimes Ca125
breast cancer:
- CA15-3
- sometimes CEA
- sometimes Ca125
lung cancer:
- sometimes Ca125 or CEA
pancreatic cancer:
- CA19-9
when is Ca19-9 raised?
pancreatic cancer
mucinous tumour of the ovary
gastric cancer
colon cancer
what does CEA stand for?
carcinoembryonic antigen
when is calcitonin a tumour marker?
medullary cell carcinoma of the thyroid
when is bHCG raised?
seminoma
choriocarcinoma
non-seminomatous germ cell tumour
what maker is raised in granulosa cell cancer of the ovary?
Inhibin
when in neurone specific enolase raised?
small cell lung cancer
neuroblastoma
what marker is raised in:
- prostate cancer?
- papillary and follicular thyroid cancer
PSA
thyroglobulin
when is placental alkaline phosphatase (PLAP) raised?
seminoma
ovarian dysgerminoma
when is the tumour marker SCC raised?
squamous cell cervical cancer
squamous head and neck cancer
what are tumour markers?
proteins secreted by tumour cells that can be detected in serum of patients to monitor progression of disease, prognosis and response to treatment
what makes a good tumour marker?
reliable, quick, cheap
high sensitivity - people with raised levels actually have the disease
high specificity - people with low levels don’t have disease
high positive predictive value - % of positive results that are true positives
high negative predictive value - % of negative results that are true negatives.
