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MSRA oncology > tumour markers > Flashcards

tumour markers Flashcards

1
Q

what categories can tumour markers be divided into?

A

monoclonal antibodies against carbodyhydrate or glycoprotein tumour antigens

tumour antigens

enzymes (alkaline phosphatase, neurone specific enolase)

hormones eg calcitonin, ADH

all have slow specificity

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2
Q

which tumour markers are monoclonal antibodies?

A

CA 125
CA 19-9
CA 15-3

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3
Q

which tumour markers are tumour antigens?

A

PSA
AFP
CEA
S-100
bombesin

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4
Q

which malignancies is CA 125 associated with?

A

ovarian ca
uterus
breast

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5
Q

what are non-malignant associations of CA-125?

A

cirrhosis
pregnancy

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6
Q

what is CA 19-9 associated with?

A

pancreatic ca
cholangiocarcinoma
colorectal ca

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7
Q

what are non-malignant conditions CA 19-9 associated with?

A

cholestasis
pancreatitis

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8
Q

what is CA 15-3 associated with?

A

breast ca
and benign breast disease

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9
Q

what is CA 27-29 associated with?

A

breast ca

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10
Q

what is PSA associated with?

A

prostate ca
BPH

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11
Q

what is AFP associated with?

A

HCC hepatocellular carcinoma
teratoma

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12
Q

what non-malignant conditions is AFP associated with?

A

hepatitis
cirrhosis
pregnancy

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13
Q

what is CEA associated with?

A

colorectal ca

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14
Q

which non-malignant conditions is CEA associated with?

A

pancreatitis
cirrhosis

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15
Q

what is S-100 associated with?

A

melanoma
schwannomas

non-malignant: sarcoma

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16
Q

what is bombesin associated with?

A

small cell lung ca
gastric ca
neuroblastoma

17
Q

what is neuron-specific elonase associated with?

A

SCLC

18
Q

what is BHCG associated with?

A

germ cell tumour
pregnancy

19
Q

what is mono Ig associated with?

A

multiple myeloma

20
Q

what is PLAP associated with?

A

seminoma

21
Q

what are acid phosphatases associated with?

A

prostate ca

22
Q

what are thyroglobulins associated with?

A

thyroid ca

calcitonin raised in medullary thyroid ca

MSRA oncology (4 decks)

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