Tumors Flashcards
Aggressive adult cancer that originates from neuroectoderm
GBM
On histology this cancer presents as necrotic, psuedopallisading necrosis
What location goes GBM present in (also radiology)
cerebellum, brainstem, or spinal cord and ring-enhacing lesion on imaging
Which cancer presents with facial numbness, facial motor impairment, vertigo in adults. SP100+. Possible hearing loss
vestibular schwanoma
This grade 2 cancer presents in the 3rd to 4th decade of life and has fried egg appearence on histology
oligodendeglioma
Which mutation has a worse prognosis in GBM? and why?
IDH wild-type because the cancer started as glioblastoma vs the other one started as a low-grade and progressed
A benign tumor of adults that arise from meningothelial cells of the arachnoid and attached to the dura
meningioma
Describe the gross morphology of meningioma
Gross: rubbery, rounded or bosselated dural masses
Tumor can spread in a sheetlike fashion along the surface of the dura.
On histology this cancer presents as whorled cells they calcify forming psammoma bodies. Long skinny cells, clusters of epithelioid cells or fibrinoid cells
Meningioma
Which cancer presents with hydrocephalus secondary to progressive obstruction of 4th ventricle
Epenydoma
How would Ependymoma present in child vs. an adult
near 4th ventricle (children), spinal cord (adults with NF2)
This grade 1 childhood tumor presents with well-diffrentiated hair-like projections and rosenthal fibers (blue eosinphilic inclusions)
Pilocystic astrocytoma
this grade 4 childhood cancer presents with morning headaches, non-communicating hydrocephalus and ataxia
medulloblastoma
Medulloblastoma histology can be described as
primitive cells, with increase mitotic figures small blue cells with minimal cytoplasm psudorosettes
Origin of craniopharyngeomas
Rathke’s piuch
Histology finding of wet keratin, cholesterol cystals
craniopharyngioma
