Tumor Supressor Genes Flashcards
1
Q
APC
A
Negatively regulates the WNT pathway by promoting the degradation of Beta-catenin
2
Q
E-cadherin
A
Contact mediated growth inhibition of epithelial cells binds and sequesters beta catenin
3
Q
CDKN2A
A
Locus that encodes two tumor suppressive proteins: p16 and ARF
4
Q
TGF-beta
A
Potent inhibitor of cellular proliferation in normal tissues
5
Q
PTEN
A
Negative regulator of PI3K/AKT signaling
6
Q
NF1
A
GTPase that acts as a negative regulator of RAS
7
Q
NF2
A
A cytoskeletal protein involved in contact inhibition
8
Q
WT1
A
Germline loss of function mutations assoc w/ wilms tumor
9
Q
PTCH1
A
Gorlin syndrome, sporadic basal cell carcinomas and medulloblastomas
10
Q
VHL
A
Responsible for degradation of hypoxia induced factors
