Tumor suppressor genes Flashcards
Condition associated with APC
Colorectal cancer (associated with FAP)
Which tumor suppressor gene is associated with Colorectal cancer (associated with FAP)
APC
Condition associated BRCA1/BRCA2
Breast, ovarian, and pancreatic cancer
Which tumor suppressor gene is associated with Breast, ovarian, and pancreatic cancer
BRCA1/BRCA2
Condition associated with CDKN2A
Melanoma, pancreatic cancer
Which tumor suppressor gene is associated with Melanoma, pancreatic cancer
CDKN2A
Condition associated with DCC
Colon cancer
Which tumor suppressor gene is associated with Colon cancer
DCC
Condition associated with SMAD4 (DPC4)
Pancreatic cancer
Which tumor suppressor gene is associated with Pancreatic cancer
SMAD4 (DPC4)
Condition associated with MEN1
M ultiple Endocrine Neoplasia I
Which tumor suppressor gene is associated with Multiple Endocrine Neoplasia I
MEN1
Condition associated with NF1
Neurofibromatosis type 1
Which tumor suppressor gene is Neurofibromatosis type 1 associated with
NF1
Condition associated with NF2
Neurofibromatosis type 2
Which tumor suppressor gene is associated with Neurofibromatosis type 2
NF2
Condition associated with PTEN
Breast, prostate, and endometrial cancer
Which tumor suppressor gene is associated with Breast, prostate, and endometrial cancer
PTEN
Condition associated with Rb
Retinoblastoma, osteosarcoma (bone cancer)
Which tumor suppressor gene is associated with Retinoblastoma, osteosarcoma (bone cancer)
Rb
Condition associated with TP53
Most human cancers, Li-Fraumeni syndrome
(multiple malignancies at early age, aka, SBLA cancer syndrome: Sarcoma, Breast, Leukemia,
Adrenal gland)
Which tumor suppressor gene is associated with Most human cancers, Li-Fraumeni syndrome
(multiple malignancies at early age, aka, SBLA
cancer syndrome: Sarcoma, Breast, Leukemia,
Adrenal gland)
TP53
Condition associated with TSC7
Tuberous sclerosis
Which tumor suppressor gene is associated with Tuberous sclerosis
TSC7
