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Cancer causing genes and agents > Tumor suppressor genes > Flashcards

Tumor suppressor genes Flashcards

1
Q

Condition associated with APC

A

Colorectal cancer (associated with FAP)

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2
Q

Which tumor suppressor gene is associated with Colorectal cancer (associated with FAP)

A

APC

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3
Q

Condition associated BRCA1/BRCA2

A

Breast, ovarian, and pancreatic cancer

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4
Q

Which tumor suppressor gene is associated with Breast, ovarian, and pancreatic cancer

A

BRCA1/BRCA2

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5
Q

Condition associated with CDKN2A

A

Melanoma, pancreatic cancer

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6
Q

Which tumor suppressor gene is associated with Melanoma, pancreatic cancer

A

CDKN2A

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7
Q

Condition associated with DCC

A

Colon cancer

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8
Q

Which tumor suppressor gene is associated with Colon cancer

A

DCC

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9
Q

Condition associated with SMAD4 (DPC4)

A

Pancreatic cancer

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10
Q

Which tumor suppressor gene is associated with Pancreatic cancer

A

SMAD4 (DPC4)

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11
Q

Condition associated with MEN1

A

M ultiple Endocrine Neoplasia I

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12
Q

Which tumor suppressor gene is associated with Multiple Endocrine Neoplasia I

A

MEN1

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13
Q

Condition associated with NF1

A

Neurofibromatosis type 1

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14
Q

Which tumor suppressor gene is Neurofibromatosis type 1 associated with

A

NF1

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15
Q

Condition associated with NF2

A

Neurofibromatosis type 2

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16
Q

Which tumor suppressor gene is associated with Neurofibromatosis type 2

A

NF2

17
Q

Condition associated with PTEN

A

Breast, prostate, and endometrial cancer

18
Q

Which tumor suppressor gene is associated with Breast, prostate, and endometrial cancer

A

PTEN

19
Q

Condition associated with Rb

A

Retinoblastoma, osteosarcoma (bone cancer)

20
Q

Which tumor suppressor gene is associated with Retinoblastoma, osteosarcoma (bone cancer)

A

Rb

21
Q

Condition associated with TP53

A

Most human cancers, Li-Fraumeni syndrome
(multiple malignancies at early age, aka, SBLA cancer syndrome: Sarcoma, Breast, Leukemia,
Adrenal gland)

22
Q

Which tumor suppressor gene is associated with Most human cancers, Li-Fraumeni syndrome
(multiple malignancies at early age, aka, SBLA
cancer syndrome: Sarcoma, Breast, Leukemia,
Adrenal gland)

A

TP53

23
Q

Condition associated with TSC7

A

Tuberous sclerosis

24
Q

Which tumor suppressor gene is associated with Tuberous sclerosis

A

TSC7

25
Q

Condition associated with TSC2

A

Tuberous sclerosis

26
Q

Which tumor suppressor gene is associated with Tuberous sclerosis

A

TSC2

27
Q

Condition associated with VHL

A

von Hippel-Lindau disease

28
Q

Which tumor suppressor gene is associated with von Hippel-Lindau disease

A

VHL

29
Q

Condition associated with WT1

A

Wilms tumor (nephroblastoma)

30
Q

Which tumor suppressor gene is associated with Wilms tumor (nephroblastoma)

A

WT1

Cancer causing genes and agents (4 decks)

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