TUMOR STAGING & GRADING Flashcards
T1-T4 is classified based on?
• EXTENT
• SIZE
limited to the kidney and are 7 cm or smaller
T1
larger, more than 7 cm, but are also in the kidney
T2
extend beyond the kidney but are within Gerota fascia and may involve neighboring veins (renal vein or inferior vena cava)
T3
invade Gerota fascia or extend to the ipsilateral adrenal gland
T4
T1 and T2 are further subdivided according to?
RENAL MASS SIZE
T3 is subdivided depending on?
venous involvement
Involvement of this structure is associated with lower survival
RENAL SINUS FAT
What tumor stage have kidney-limited lesions only?
stage 1 or 2
What stage when there is any nodal involvement, regardless of kidney size or T staging?
STAGE 3
What tumor stage when Gerota fascia invasion, adrenal gland, or distant metastasis occurs?
STAGE 4
What summarizes the TNM findings?
STAGING
What determines prognosis based on nuclear features?
GRADING
How many T categories?
• 5
• T0, T1, T2, T3, T4
How many T1 subcategories?
• 2
• T1a, T1b
How many T2 subcategories?
• 2
• T2a, T2b
How many T3 subcategories?
• 3
• T3a, T3b, T3c
What T category if tumor size <7?
T1
What T category if tumor size <4?
T1a
What T category if tumor size 4-7?
T1b
What T category if tumor size >7?
T2
What T category if tumor size 7-10?
T2a
What T category if tumor size >10?
T2b
What T category if involvement of major veins or perinephric tissues but no ipsilateral adrenal gland?
T3
What T category if with involvement of renal vein and branches or Renal pelvis and calyces or Perirenal ± renal sinus fat?
T3a
What T category if with involvement of Vena cava below the diaphragm?
T3b
What T category if with involvement vena cava above the diaphragm or vena cava wall?
T3c
What T category if with involvement of Ipsilateral adrenal gland?
T4
Fuhrman grading is based on what 3 parameters?
- Nuclear size
- Irregularity
- Nucleoli prominence
What Fuhrman grade if tumors have small nuclei and no nucleoli?
Fuhrman Grade 1
What Fuhrman grade have larger irregular nuclei and the presence of nucleoli?
Fuhrman Grade 2
What Fuhrman grade have large irregular nuclei and with more visible nucleoli?
Fuhrman Grade 3
What Fuhrman grade have extremely abnormal nuclei and highly prominent nucleoli apparent at low power?
Fuhrman Grade 4
Fuhrman grading has been used in what type of RCC?
ccRCC