Tumor Markers

Question 0

Tumor marker and associated neoplasm

Carcinoembryonic antigen (CEA)

Answer 0

Adenocarcinomas of the colon,Lung, breast, stomach, pancreas

Question 1

Oncofetal ANTIGENS

Answer 1

Carcinoembryonic antigen (CEA) 
Alfa-fetoprotein 

Present in fetal tissue but normally are suppressed after birth.

Their present in large amounts may reflect an anaplastic process in tumor cells.

Question 2

Tumor marker and associated neoplasm

Alfa-fetoprotein (AFP)

Answer 2

Hepatocellular carcinoma, gonadal germ cell rumors (seminoma)

Question 3

Tumor marker

Answer 3

A protein molecule detectable in serum or other body fluids. Used as a biochemical indicator of the presence of the malignancy. Small amounts of tumor marker proteins are found in normal body tissues or benign tumors and are not specific for malignancy.

high levels are suspicious and mandate follow-up diagnostic studies.

Tumor marker tests are most useful for monitoring the patient’s response to therapy and for detecting residual disease.

Tumor markers fall into two general categories:

• derived from the tumor itself
• associated with host (immune) response to the tumor

Question 4

Hormones

Answer 4

Human chorionic gonadotropin (HCG) 
Calcitonin 
Catecholamines/metabolites 
Antidiuretic hormone (ADH) 
Parathyroid hormone (PTH) 

Present in considerable amounts in human blood and tissues, but very high levels not r/t other conditions may signify the presence of a hormone secreting malignancy.