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Path tumor marker > Tumor Markers > Flashcards

Tumor Markers Flashcards

1
Q

SIS B Chain PDGF

A

Astrocytoma , osteosarcoma

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2
Q

EGF-TGF a

A

Astrocytoma , hepatocellular carcinoma

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3
Q

HST1

A

Stomach cancer

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4
Q

INT2 (official name FGF3)

A

Bladder cancer, Breast cancer, Melanoma

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5
Q

HGF

A

Thyroid cancer

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6
Q

ERB-B1

A

Squamous CC of lung , gliomas

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7
Q

ERB-B2/ HER2 /neu

A

Breast and ovarian

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8
Q

FMS

A

Leukemia

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9
Q

RET

A

MEN 2A and 2B , Familial medullary Thyroid carcinoma

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10
Q

KIT

A

GI stromal tumours, soft tissue tumors (Seminoma)

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11
Q

PDGF-R

A

Gliomas, leukemias

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12
Q

H-RAS

A

kidney, bladder

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13
Q

K-RAS

A

Colon, pancreas. Lung

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14
Q

N-RAS

A

Haematological malignancies, melanoma

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15
Q

ABL: BCR

A

CML (95%) , ALL (5%)

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16
Q

BRAF

A

Melanoma

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17
Q

Beta CATENIN

A

Hepatoblastoma, hepatocellular carcinoma

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18
Q

C-MYC

A

Burkitts lymphoma t(8:14)

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19
Q

N-MYC

A

Neuroblastoma, Small CC of lung

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20
Q

L-MYC

A

Small CC of lung

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21
Q

CYCLIN D Translocation

A

Mantle cell Lymphoma t(11:14)

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22
Q

CYCLIN D Amplification

A

Breast / esophagus

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23
Q

CYCLIN E

A

Breast

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24
Q

CDK4

A

Glioblastomas, melanomas, sarcoma

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25
Q

P16

A

Melanomas

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26
Q

P53

A

Li- Fraumeni Syndrome

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27
Q

RB

A

Retinoblastoma, osteocarcoma, breast

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28
Q

NF1

A

Neurofibroma, Fibrosarcoma

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29
Q

APC

A

Colorectal, lung, esophagus, stomach, pancreas

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30
Q

NF2

A

Bilateral schwannoma

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31
Q

TGF-BETA

A

Pancreas, colon

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32
Q

VHL

A

Renal cysts, Renal CC, pheochromocytoma, hemangiomas of CNS, retinal angioblastoma

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33
Q

PTEN

A

Cowden syndrome- breast, thyroid, endometrial

34
Q

TSC1

A

Tuberous sclerosis

35
Q

TSC2

A

Tuberous sclerosis

36
Q

WT1

A

Wilms tumor (nephroblastoma)

37
Q

WT2

A

Wilms tumor (nephroblastoma)

38
Q

DPC4/SMAD4

A

Pancreatic adenocarcinoma

39
Q

DCC

A

Colorectal cancer

40
Q

INK4A/ARF

A

familial melanoma, sq CC of esophagus, sporadic pancreatic adenocarcinoma

41
Q

E-cadherin

A

Familial gastric cancer

42
Q

TGF-β receptor

A

Carcinomas of colon

43
Q

BCL2

A

Follicular Bcell lymphoma t(14:18)

44
Q

ATM

A

Malignant lymphoma

45
Q

BRCA1

A

Breast , ovary, prostate, colon

46
Q

BRCA2

A

Breast

47
Q

CD45

A

Common leukocytic antigen, leukocytic malignancies

48
Q

S100

A

Neuroendocrine tumors

49
Q

NSE

A

Neuroendocrine tumors

50
Q

Cytokeratin

A

Adenocarcinomas

51
Q

EMA

A

Epithelial: carcinoma

52
Q

CEA

A

Colorectal and pancreatic adenocarcinomas

53
Q

Vimentin

A

Sarcoma

54
Q

Desmin

A

Muscle derived sarcoma

55
Q

Factor VIII

A

Tumors of epithelium

56
Q

AFP

A

HCC, yolk sac tumor or ovary or testis

57
Q

BENCE JONES PROTEIN

A

Multiple myeloma, waldenstroms macroglobinemia

58
Q

CA 15-3

A

Breast

59
Q

CA 19-9

A

Pancreas, colon, stomach

60
Q

CA 125

A

Surface derived ovarian cancer

61
Q

PSA

A

Prostatic carcinoma

62
Q

CD10

A

Renal CC , Acute lymphoblastic leukemia, follicular lymphoma, burkitt lymphoma

63
Q

CD15, CD30

A

Hodgkins disease, popcorn cells/ RS cells/ lacuner cells

64
Q

CD1a

A

Langerhan’s Histiocytosis

65
Q

CD3

A

T cell lymphoma

66
Q

CD20

A

B cell lymphoma

67
Q

CD11c, CD25, CD103

A

Hairy cell lymphoma

68
Q

Human Chorionic Gonadotropin

A

Trophoblastic tumors, nonseminomatous testicular tumors

69
Q

Calcitonin

A

Medullary carcinoma of thyroid

70
Q

Catecholamine

A

Pheochromocytoma

71
Q

Prostatic acid phosphatase

A

Prostate cancer

72
Q

Neuron Specific Enolase

A

Sm CC of lung, neuroblastoma

73
Q

Tonofilaments

A

Epithelial tumors

74
Q

Weibel Palade Bodies

A

Angiosarcomas

75
Q

Neurosecretory Granules

A

APUD tumors

76
Q

Melanosomes

A

Malignant melanoma

77
Q

Birbeck Granules

A

Histiocytic tumor

78
Q

Alkaline Phosphatase

A

Seminoma

79
Q

Bombesin

A

Neuroblastoma, lung, gastric

80
Q

TRAP

A

Hairy cell leukemia

Path tumor marker (1 decks)

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