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Clinical Chemistry 2 > Tumor Markers > Flashcards

Tumor Markers Flashcards

1
Q

1846- H. Bence-Jones

A

Bence-Jones protein

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2
Q

1928- W.H. Brown

A

Ectopic hormone syndrome

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3
Q

1930- B. Zondek

A

hCG

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4
Q

1932- H. Cushing

A

ACTH

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5
Q

1949- K. Oh-Uti

A

Deletions of blood group antigens

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6
Q

1959- C. Market

A

Isoenzyme

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7
Q

1963- G.I. Abelev

A

AFP

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8
Q

1965- P. Gold and S. Freeman

A

CEA

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9
Q

1969- R. Heubner and G. Todaro

A

Oncogenes

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10
Q

1975- H. Kohler and G. Milstein

A

Monoclonal antibodies

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11
Q

1980- G. Cooper, R. Weinberg, and M. Bishop

A

Oncogenes probe and transfection

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12
Q

1985- H. Harris, R. Sager, and A. Knudson

A

Supressor gene

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13
Q

Alcohol dehydrogenase

A

ASSAY: ACT
CANCER TYPE: Liver

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14
Q

ALS

A

ASSAYY: ACT
CT: Liver

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15
Q

ALP

A

ASSAY: ACT
CT: Bone, liver, leukemia, sarcoma

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16
Q

ALP-placenta

A

ASSAY: ACT
CT: Ovarian, lung, trophoblastic, GIT, seminoma, Hodgkin’s

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17
Q

AMS

A

ASSAY: ACT
CT: Pancreatic, various

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18
Q

Aryl sulfatase B

A

ASSAY: ACT
CT: Colon, breast

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19
Q

CK-BB

A

ASSAY: ACT
CT: Prostate, lung (small-cell), breast, ovarian

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20
Q

Esterase

A

ASSAY: ACT
CT: Breast

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21
Q

Galactosyltransferase

A

ASSAY: ACT
CT: Colon, bladder, GIT, various

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22
Q

GGT

A

ASSAY: Liver

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23
Q

Hexokinase

A

ASSAY: ACT
CT: Liver

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24
Q

LAP

A

ASSAY: ACT
CT: Pancreatic, liver

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25
Q

LDH

A

ASSAY: ACT
CT: Liver, lymphomas, leukemia, various

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26
Q

Neuro-specific enolase

A

ASSAY: RIA
CT: Lunng (small cell), neuroblastoma, carcinoid, melanoma, pheochromocytoma, pancreatic

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27
Q

5’-NT

A

ASSAY: ACT
CT: Liver

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28
Q

ACP- Prostatic

A

ASSAY: ACT/MIA
CT: Prostate

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29
Q

PSA

A

ASSAY: IMA
CT: Protate

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30
Q

PK

A

ASSAY: ACT
CT: Liver, various

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31
Q

Ribonucleases

A

ASSAY: ACT
CT: Various (ovarian, lung, large bowel)

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32
Q

Sialytransferase

A

ASSAY: ACT
CT: Breast, colon, lung

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33
Q

tdt

A

ASSAY: ACT
CT: Leukemia

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34
Q

Thymidine kinase

A

ASSAY: RIA/ACT
CT: Various, leukemia, lymphomas, lung (small cell)

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35
Q

ACTH

A

CANCER TYPE: Cushing’s syndrome, lung (small cell)

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36
Q

ADH

A

CANCER TYPE: Lung (small cell), adrenal cortex, pancreatic, duodenal

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37
Q

Bombesin

A

CANCER TYPE: Lung (small cell)

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38
Q

Calcitonin

A

CANCER TYPE: Medullary thyroid

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39
Q

Gastrin

A

CANCER TYPE: Glucagon

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40
Q

GH

A

CANCER TYPE: Pituitary adenoma, renal, lung

41
Q

hCG

A

CANCER TYPE: Embryonal, choriocarcinoma, testicular (nonseminomas)

42
Q

Human placental lactogen

A

CANCER TYPE: Trophoblastic, gonads, lung, breast

43
Q

Neurophysin

A

CANCER TYPE: Lung (samll-cell)

44
Q

PTH

A

CANCER TYPE: Liver, renal, breast, lung, various

45
Q

PRL

A

CANCER TYPE: Pituitary adenoma, renal, lung

46
Q

Vasoactive intestinal peptide

A

CANCER TYPE: Pancrease, bronchogenic, pheochromocytoma, neuroblastoma

47
Q

AFP

A

NATURE: Glycoprotein, 70 kd, 4% CHO
CANCER TYPE: Hepatocellular, germ cell (nonseminoma)

48
Q

b- Oncofetal antigen

A

NATURE: Glycoprotein, 80 kd
CANCER TYPE: Colon

49
Q

Carcinofetal ferritin

A

NATURE: Glycoprotein, 600 kd
CANCER TYPE: Liver

50
Q

CEA

A

NATURE: Glycoprotein, 22 kd, 50% CHO
CANCER TYPE: Colorectal, GIT, pancreatic, lung, breast

51
Q

Pancreatic oncofetal

A

NATURE: Glycoprotin, 40 kd
CANCER TYPE: Pancreatic

52
Q

Squamous cel antigen

A

NATURE: Glycoprotein, 44-48 kd
CANCER TYPE: Cervical, lung, skin, head & neck (squamous)

53
Q

Tennesse antigen

A

NATURE: Glycoprotein, 100 kd
CANCER TYPE: Colon, GIT, bladder

54
Q

Tissue polypeptide antigen

A

NATURE: Cytokeratins 8, 18, 19
CANCER TYPE: Various (breast, colorectal, ovarian, bladder)

55
Q

CA 125

A

Ag & SOURCE: GP, >200kd, OVCA 433
Ab: OC 125
CANCER TYPE: Ovarian endometrial

56
Q

CA 15-3

A

Ag & Source: GP, 400kd, membrane-enriched BrCa
Ab: DF3 & 115D8
CANCER TYPE: Breast, ovarian

57
Q

CA 549

A

Ag & Source: HMW GP
Ab: BC4E549, BC4N154
CANCER TYPE: Breast, ovarian

58
Q

CA 27, 29

A

Ag & Source: HMW GP
Ab: B27.29
CANCER TYPE: Breast

59
Q

MCA

A

Ag & Source: 350-kd GP
Ab: b-12
CANCER TYPE: Breast, ovarian

60
Q

DU-PAN-2

A

Ag & Source: Mucin, 1000-kd peptide epitope
Ab: DU-PAN-2
CANCER TYPE: Pancreatic, ovarian, GIT, lung

61
Q

CA A9-9

A

Ab & Source: Sialylated Le^xa, SW-1116 colon CA
Ab: 19-9
CANCER TYPE: Pancreatic, GIT, hepatic

62
Q

CA 19-5

A

Ab & Source: Le^a & Sialylated Le^ag
Ab: 19-5
CANCER TYPE: Pancreatic, GIT, ovarian

63
Q

CA 50

A

Ab & Source: Sialylated Le^a and afucosyl
Ab: C50
CANCER TYPE: Pancreatic, GIT, colon

64
Q

CA 72-4

A

Ab & Source: Sialylated Tn
Ab: B27.3, CC49
CANCER TYPE: Ovarian, breast, GIT, colon

65
Q

CA 242

A

Ab & Source: Sialylated CHO
Ab: C242
CANCER TYPE: GIT, pancreatic

66
Q

b2- Microglobulin

A

NATURE: 11 kd
CANCER TYPE: Multiple myeloma, B-cell lymphoma, CLL, Waldenstron’s macroglobulinemia

67
Q

C-peptide

A

NATURE: 3.6 kd
CANCER TYPE: Insulinoma

68
Q

Ferritin

A

NATURE: 450 kd Fe-binding protein
CANCER TYPE: Liver, lung, breast, leukemia

69
Q

Immunoglobulin

A

NATURE: 160-900 kd, 3-12% CHO
CANCER TYPE: Multiple myeloma, lymphomas

70
Q

Melanoma-associated antigen

A

NATURE: 90-240 kd
CANCER TYPE: Melanoma

71
Q

Pancreas-associated antigen

A

NATURE: 100 kd, 20% CHO
CANCER TYPE: Pancreatic, stomach

72
Q

Pregnancy-specific protein 1

A

NATURE: 10 kd, 30% CHO
CANCER TYPE: Trophoblastic, germ cell

73
Q

Prothrombin presursor

A

NATURE: Des-r-carboxy prothrombin
CANCER TYPE: Hepatocellular

74
Q

Tumor-associated trypsin-inhibitor

A

NATURE: 6 kd-polypeptide
CANCER TYPE: Lung, GIT, ovarian

75
Q

Estrogen & progesterone receptors

A

NATURE: (Tissue)
CANCER TYPE: Breast

76
Q

Cathecholamine metabolites

A

NATURE: (Urine) VMA, HVA, metanephrines
CANCER TYPE: Neuroblastma, pheochromocytoma

77
Q

Hydroxyproline

A

NATURE: (Urine)
CANCER TYPE: Bone metastasis (breast), multiple myeloma

78
Q

Lipid-associated sialic acid

A

NATURE: Sialic acid
CANCER TYPE: GIT, lung, rheumatoid

79
Q

Polyamine

A

NATURE: (CSF), (URINE)
CANCER TYPE: Brain, Various

80
Q

N-ras mutation

A

FUNCTION: Signal transduction
PRODUCT: GDP/GTP binding protein
TYPE OF CANCER: Acute myeloid leukemia neuroblastoma

81
Q

K-ras mutation

A

FUNCTION: Signal transduction
PRODUCT: GDP/GTP binding protein
TYPE OF CANCER: Leukemia, lyphoma

82
Q

c-myc translocation

A

FUNCTION: Transcription regulation
PRODUCT: Binds to DNA
TYPE OF CANCER: B and T lymphoma, small cell lung carcinoma

83
Q

c-erb B-2 amplification

A

FUNCTION: Growth receptor
PRODUCT: Tyrosine kinase
TYPE OF CANCER: Breast, ovarian, gastrointestinal

84
Q

c-ab/bcr translocation

A

FUNCTION: Signal transduction
PRODUCT: Tyrosine kinase
TYPE OF CANCER: Chronic myelocytic leukemia

85
Q

N-myc amplification

A

FUNCTION: Transcription regulation
PRODUCT: Binds to DNA
TYPE OF CANCER: Neuroendocrine

86
Q

bcl-2

A

FUNCTION: Blocks apoptosis
PRODUCT: Mitchondrial membrane protein
TYPE OF CANCER: Leukemia, lymphoma

87
Q

3p

A

TUMOR TYPE: Kidney
GENE: VHL mutation

88
Q

5q21

A

TUMOR TYPE: Colorectal
GENE: APC mutation

89
Q

9p21

A

TUMOR TYPE: Bladder, glioblastoma, melanoma
GENE: p16 (cdka2) mutation

90
Q

11p13

A

TUMOR TYPE: Wilms’ tumor
GENE: WT1 mutation

91
Q

11p15

A

TUMOR TYPE: Wilms’, breast, hepatoblastoma, rhabdomayosarcoma, bladder
GENE: Loss of heteroxygosity

92
Q

13q

A

TUMOR TYPE: Breast
GENE: BRCA2, RB1

93
Q

13q14

A

TUMOR TYPE: Retinoblastoma, osteosarcoma, small-cell lung
GENE: RB1 mutation

94
Q

16q

A

TUMOR TYPE: Breast
GENE: P16 E-cadherin mutation

95
Q

17q

A

TUMOR TYPE: Neurofibrosis 1, melanoma, breast
GENE: BRCA 1 MUTATION

96
Q

17P13

A

TUMOR TYPE: Breast, colorectal, lung, liver, renal cell, bladder, sarcomas
GENE: p53 mutation

97
Q

18q21

A

TUMOR TYPE: Colorectal
GENE: DCC mutation

98
Q

22q

A

TUMOR TYPE: Neurofibromatosis 2, meningioma
GENE: NF2 MUTATION

Clinical Chemistry 2 (1 decks)

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