Tumor Markers

Question 0

CEA

Answer 0

Colon and other GI

Question 1

PSA

Answer 1

Prostate

Question 2

CA125

Answer 2

Ovaries

Question 3

HER2/neu

Answer 3

Breast

Question 4

CD20

Answer 4

B-cell lymphoma

Question 5

C-kit

Answer 5

GI stromal

Question 6

EGFR

Answer 6

Lung and colon cancer

Question 7

Cytokeratins

Answer 7

Carcinomas

Question 8

Thyroglobulin

Answer 8

Thyroid

Question 9

Lewis a antigen (CA 19-9)

Answer 9

Pancreas and GI

Question 10

Estrogen and progesterone

Answer 10

Breast

Question 11

Chromogranins

Answer 11

Neuroendocrine

Question 12

Synaptophysin

Answer 12

Neuroendocrine

Question 13

Leu-7 (CD57)

Answer 13

Neuroendocrine

Question 14

CK20

Answer 14

Colon

Question 15

HMB-45 and S-100

Answer 15

Melanoma

Question 16

Vimentin

Answer 16

Soft tissue sarcoma

Question 17

Desmin

Answer 17

Smooth or striated muscle

Question 18

Muscle-specific actin

Answer 18

Muscle

Question 19

Neurofilament proteins

Answer 19

Neurons (ex. neuroblastoma and ganglioneuroma)

Question 20

GFAP, Glial Fibrillary Acidic Protein

Answer 20

Astrocytes, other glial cells

Question 21

LCA (CD45)

Answer 21

Leukocyte common antigen - malignant lymphoma

Question 22

Factor VIII related antigen

Answer 22

Vascular tumors (ex. hemangioma, hemangiosarcoma)

Question 23

AFP

Answer 23

Liver or non-seminomatous germ cell (yolk sac) tumors

Question 24

PCNA

Answer 24

Proliferating cell nuclear antigen - cell proliferation

Question 25

PLAP, placental alkaline phosphatase

Answer 25

Seminoma or embryonal carcinoma (testis or ovary)

Question 26

hCG

Answer 26

Trophoblastic tumors, ex. choriocarcinoma (placenta)

Question 27

Calcitonin

Answer 27

Thyroid

Question 28

Bcl-1 and cycling D1

Answer 28

Mantle cell lymphoma

Question 29

Pigmented metastases

Answer 29

Malignant melanoma

Question 31

CD4

Answer 31

T cells

Question 32

Ki-67

Answer 32

cell proliferation