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Unit 1: Neoplasia > Tumor Markers > Flashcards

Tumor Markers Flashcards

Match cancer marker to organ(s) affected

0
Q

CEA

A

Colon and other GI

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1
Q

PSA

A

Prostate

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2
Q

CA125

A

Ovaries

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3
Q

HER2/neu

A

Breast

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4
Q

CD20

A

B-cell lymphoma

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5
Q

C-kit

A

GI stromal

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6
Q

EGFR

A

Lung and colon cancer

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7
Q

Cytokeratins

A

Carcinomas

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8
Q

Thyroglobulin

A

Thyroid

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9
Q

Lewis a antigen (CA 19-9)

A

Pancreas and GI

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10
Q

Estrogen and progesterone

A

Breast

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11
Q

Chromogranins

A

Neuroendocrine

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12
Q

Synaptophysin

A

Neuroendocrine

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13
Q

Leu-7 (CD57)

A

Neuroendocrine

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14
Q

CK20

A

Colon

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15
Q

HMB-45 and S-100

A

Melanoma

16
Q

Vimentin

A

Soft tissue sarcoma

17
Q

Desmin

A

Smooth or striated muscle

18
Q

Muscle-specific actin

A

Muscle

19
Q

Neurofilament proteins

A

Neurons (ex. neuroblastoma and ganglioneuroma)

20
Q

GFAP, Glial Fibrillary Acidic Protein

A

Astrocytes, other glial cells

21
Q

LCA (CD45)

A

Leukocyte common antigen - malignant lymphoma

22
Q

Factor VIII related antigen

A

Vascular tumors (ex. hemangioma, hemangiosarcoma)

23
Q

AFP

A

Liver or non-seminomatous germ cell (yolk sac) tumors

24
Q

PCNA

A

Proliferating cell nuclear antigen - cell proliferation

25
Q

PLAP, placental alkaline phosphatase

A

Seminoma or embryonal carcinoma (testis or ovary)

26
Q

hCG

A

Trophoblastic tumors, ex. choriocarcinoma (placenta)

27
Q

Calcitonin

A

Thyroid

28
Q

Bcl-1 and cycling D1

A

Mantle cell lymphoma

29
Q

Pigmented metastases

A

Malignant melanoma

31
Q

CD4

A

T cells

32
Q

Ki-67

A

cell proliferation

Unit 1: Neoplasia (4 decks)

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