Tumor angiogenesis Flashcards
1
Q
vasculogenesis vs angiogenesis
A
vasculogenesis: de novo
angiogenesis: from existing
2
Q
what triggers angiogenesis?
A
tissue hypoxia starts cascade of cell events, leading to VEGF
3
Q
why do drugs often have tough time getting inside a tumor?
A
-there is high pressure inside tumor because lymph vessels aren’t functioning well–congestion causes high pressure
4
Q
what is different about tumor vessel wall?
A
-pericytes do not cover the entire vessel. lots of leakage.
