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Tumor > Tumor > Flashcards

Tumor Flashcards

1
Q

S100+

A 
Chondroblastoma
Eosinophilic granuloma
Schwannoma
MPNST
Melanoma
\+/- Neurofibromas
Synovial sarcoma
Clear cell sarcoma
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2
Q

Metaphyseal

A

Chondromyxoid fibroma

Chondrosarcoma

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3
Q

Most common primary malignant spine tumor

A

Chordoma

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4
Q

Keratin positive

A 
Adamantinoma
Chordoma
Epitheloid sarcoma
Synovial sarcoma
CARCINOMAS
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5
Q

Ubiquitin specific protease USP6

A

ABC

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6
Q

Multiple enchondromas diseases

A

Ollier’s

Maffucci’s (+ angiomas, malignant transformation)

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7
Q

Vertebra plana (MELT)

A

Mets/Myeloma
EG + Ewing’s
Lymphoma + leukemia
Trauma + TB

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8
Q

Hand-Schuller-Christian disease

A

EG with skull and visceral lesions, diabetes insipidus, exophthalmos
Kids >3
Give CHEMO

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9
Q

Letterer-Siwe disease

A

Form of EG

FATAL (age <3)

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10
Q

CD99

A

Ewing’s

Other neuroendocrine tumors (PNET)

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11
Q

Staging for Ewing’s

A

Bone scan
BM biopsy
CT chest

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12
Q

Fibrodysplasia ossificans progressiva

A

Form of myositis ossificans
ACVR1 gene mutation
BMP4

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13
Q

Melorheostosis

A

Formation of new periosteal bone
More common in LE
Symptomatic tx

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14
Q

Multiple NOF disorder

A

Jaffe-Campanacci syndrome (+ MR, cafe au lait spots)

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15
Q

What can mimic NOF

A

Adductor magnus insertion avulsion

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16
Q

Fibrous dysplasia mutation

A

GS alpha protein ACTIVATING mutation

Increases cAMP

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17
Q

McCune-Albright syndrome

A

Poly-ostotic fibrous dysplasia
Coast of Maine spots (jagged edges)
Precocious puberty

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18
Q

Mazabraud syndrome

A

Poly-ostotic fibrous dysplasia + muscular myxomas

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19
Q

Medical treatments for GCT

A

Bisphosphonates

Denosumab

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20
Q

t(12;16) translocation

A 
Myxoid liposarcoma (TLS-CHOP)
Signet ring cells
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21
Q

MDM2/CDK4 biomarkers

A

Liposarcoma

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22
Q

Most common site of bone mets

A

T spine

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23
Q

When to get skeletal survey for stagings

A

Myeloma

Thyroid CA

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24
Q

Myeloma biomarker

A

CD38

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25
Q

Rhabdomyosarcoma staging

A

BM biopsy

CT chest

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26
Q

t(2:13) or (1:13) translocation

A

Rhabdomyosarcoma

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27
Q

Rhabdomyosarcoma fusion protein

A

Pax3 or Pax7-FKHR

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28
Q

Rhabdomyosarcoma biomarker

A

Desmin

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29
Q

Origin of osteochondromas

A

Perichondrial ring

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30
Q

Normal cartilage cap in osteochondromas

A

<2 cm

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31
Q

Mutation in MHE

A

Prehypertrophic chondrocyte layer

32
Q

When osteochondromas grow TOWARDS joints

A

Metachondromatosis (enchondromas + osteochondromas)

33
Q

Osteiod osteoma products that cause pain

A

Prostaglandin E2

Cox 1/2

34
Q

Type of osteosarcoma NOT responsive to chemo

A

Parosteal

35
Q

Gene assoc w/ Schwannoma

A

NF2

36
Q

Gene assoc w/ MPNST

A

NF1

37
Q

Neoplastic cell in PVNS

A

Phagocyte

38
Q

Lymph node mets mnemonic (ESARC)

A 
Epitheloid
Synovial sarcoma
Angiosarcoma
Rhabdomyosarcoma
Clear cell sarcoma
39
Q

Diaphyseal tumors (AEIOU Y)

A 
Adamantinoma
Eosinophilic granuloma
Infection
Osteoid osteoma, osteoblastoma
Ewing's
Y = Myeloma, lymphoma, fibrous dysplasia
40
Q

t(12:22) translocation

A

Clear cell sarcoma

41
Q

MIC-2 biomarker

A

Ewing’s

42
Q

HMB45 biomarker

A

Melanoma

Clear cell sarcoma

43
Q

t(12:16) translocation

A

Myxoid liposarcoma

44
Q

t(2:13) or (1:13) translocation

A

Rhabdomyosarcoma (alveolar)

45
Q

Small round blue cell tumors (LERNM)

A 
Lymphoma
Ewing's
Rhabdomyosarcoma
Neuroblastoma
Myeloma
46
Q

Li Fraumeni syndrome (SBLA)

A

Sarcoma
Breast
Leukemia
Adrenal gland

47
Q

POEMS syndrome assoc w/ myeloma

A 
Polyneuropathy (PN damage)
Organomegaly
Endocrinopathy
M-protein (immunoglobulin)
Skin abnormalities (hyperpigmentation)
48
Q

Get a BM biopsy

A

Ewing’s

Myeloma

49
Q

Get a bone scan

A

Osteosarcoma
Ewing’s
Mets

50
Q

Rb chromosomal abnormality

A

Chr 13

51
Q

CD34, CD31

A

Hemangioma
Hemangioendothelioma
Angiosarcoma

52
Q

Beta catenin

A

Fibromatosis

53
Q

Epithelial membrane antigen

A

Epithelioid sarcoma

Synovial sarcoma

54
Q

Rimming osteoblasts

A

Osteofibrous dysplasia

Osteoblastoma

55
Q

Worst prognosis when bone mets are present

A

Lung CA

Melanoma

56
Q

t(9:22) translocation

A

Extraskeletal myxoid chondrosarcoma

57
Q

Colony stimulating factor 1 (CSF1)

A

PVNS

58
Q

Pathology in tumoral calcinosis

A

Phosphate metabolism

59
Q

MHE gene product functions on:

A

FGF

Indian hedgehog

60
Q

Another name for Schwannoma

A

Neurilemoma

Peripheral nerve sheath tumor

61
Q

Radiation resistant tumors

A

Renal

Thyroid

62
Q

Worst prognostic factor for osteosarcoma

A

Bone mets

63
Q

Most common cause of myositis ossificans

A

Contusion

64
Q

Nerve roots preserved for near normal bowel/bladder fxn after sacral chordoma resection

A

Bilateral S2 OR

Unilateral S2-4

65
Q

Inferior scapular mass

A

Elastofibroma

66
Q

Most common small round blue cell tumor in kid <5

A

Metastatic neuroblastoma

67
Q

Most common site of mets from soft tissue sarcoma

A

Lungs

68
Q

Most common hand malignancy

A

SCC

69
Q

Synovial sarcoma translocation

A

t(X:18)

70
Q

Synovial sarcoma fusion protein

A

SYT-SSX

71
Q

Type of osteosarcoma NOT treated with chemo

A

PAROSTEAL

72
Q

DDx small round blue cells in kids

A 
Rhabdomyosarcoma
NHL
Ewing's
Wilm's
Neuroblastoma
73
Q

Rads RESISTANT mets

A

Renal

GI

74
Q

Vertebral body vertical striations on XR

A

Hemangioma

75
Q

Assoc w/ arsenic exposure

A

Hemangiosarcoma

Tumor (1 decks)

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