Tuesday, 2-28-Medical conditions in pregnancy (Wootton) Flashcards

1
Q

when do you screen for Gestational DM? How do you screen?

A

24-28 weeks

50 gm 1 hr oral load glucose challenge test –> if abnormal followed by a 3 hr 100 gm oral load glucose tolerance test

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2
Q

risk factors for GDM development?

A
  • fat
  • previous hx of GDM
  • strong FH of DM
  • known glucose intolerance
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3
Q

maternal complications of GDM?

A
  • increase risk of gestational HTN
  • increased risk of preeclampsia
  • greater risk of C section
  • increase risk of developing diabetes later
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4
Q

fetal complications of GDM?

A
  • MACROSOMIA
  • neonatal hypoglycemia
  • hyperbilirubinemia
  • operative delivery
  • SHOULDER DYSTOCIA
  • birth trauma
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5
Q

maternal complications of Pregestational diabetes?

A

worsening nephropathy and retinopathy, increased risk of developing preeclampsia, greater risk of DKA

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6
Q

fetal complications from pre gestational diabetes?

A

increase risk of spontaneous abortions, anatomic birth defects (sacral agenesis), fetal growth restriction and prematurity

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7
Q

with good glycemic control, fasting glucose should be less than __ mg/dl, 2 hour postprandial glucose less than __ mg/dl

A

fasting < 90

2 hr postprandial <120

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8
Q

maternal evaluation for antepartum mgmt of preexisting diabetes?

A

renal-24 hr collections every trimester
cardiac-EKG
ophthalmic-detailed eye exam in 1st tri
glycemic control-monitor daily fingerstick glucose values and HgBA1C

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9
Q

fetal evaluation for anterpartum mgmt of preexisting diabetes?

A

early dating US
BCHEM testing for congenital malformations at 16-20 wks
fetal testing (NST/BPP) every week starting 32-34 wks

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10
Q

at what US-estimated fetal weight would you want to recommend caesarean delivery?

A

4500 gm

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11
Q

how to dx maternal hyperthyroidism?

A

elevated free T4 and suppressed TSH

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12
Q

When to use methimazole and/or PTU for maternal hyperthyroidism?

A

methimazole in 2nd and 3rd trimester –> can cause aplasia cutis and choanal atresia in 1st tri

PTU in 1st trimester only –> increased risk of liver toxicity if beyond 1st tri

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13
Q

monitor levels of what throughout pregnancy with maternal hyperthyroidism?

A

TSH

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14
Q

signs and symptoms of thyroid storm? tx?

A

s/s: hyperthermia, tachy, perspiring, high CO failure, maternal mortality rate of ~25%

tx: B-blockers (propanolol)), block secretion of thyroid hormone (Na iodide), stop synthesis of thyroid hormone (PTU), halting peripheral conversion of T4 to T3 (dexamethasone), replace fluid loss, bring temp down

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15
Q

increased risk associated with untreated maternal hypothyroidism? tx? monitor what monthly?

A
increased risk:
spontaneous abortion
preeclampsia
abruption
low birth weight infants
stillbirth
low intelligence

tx: thyroid replacement, i.e., Levothyroxine

monitor TSH and free T3/4 levels monthly

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16
Q

result of neonatal hypothyroidism?

A

deficiency results in generalized developmental retardation

17
Q

flares of SLE tx with? fetal complications?

A

tx with prednisone

fetal complications: preterm delivery, fetal growth restrictions, stillbirth, miscarriage

18
Q

pregnancy complications in mother w/ antiphospholipid syndrome? tx w/?

A

increase risk of miscarriage
risk for developing preeclampsia
fetal growth restriction

tx: heparin/LMW heparin and low-dose aspirin

19
Q

most common cause of asymptomatic bacteriuria/UTI in pregnant mom? tx?

A

E coli

may need suppressive abx tx with recurrent infx

20
Q

pyelonephritis in mom can result in what? tx?

A

can result in adult RDS

Tx: IV hydration, abx, antipyretics, tocolytics if needed, will need suppression for remainder of pregnancy

21
Q

tx of n/v of pregnancy?

A

symptomatic-vit B6, doxylamine, promethazine

50-80% of women complain of n/v during first 8-12 weeks

22
Q

when does hyperemesis gravidarum frequently occur? outcomes? tx?

A

frequently in 1st pregnancies, multiple pregnancies, trophoblastic disease

outcomes are good

tx is symptomatic

23
Q

tx of GERD? tx of peptic ulcer?

A

GERD: symptomatic –> small meals, avoid lying down after eating, elevate head when sleeping, antacids, H2 blockers/PPIs

Ulcers: pregnancy may improve condition, tx is avoid caffeine, alcohol, tobacco, spicy foods; antacids, H2 blockers/PPIs, abx tx to tx H pyolori

24
Q

tx of acute fatty liver of pregnancy?

A
  • termination of pregnancy
  • supportive care –> IV fluids w/10% glucose, FFP and cryoprecipitate
  • maternal mortality 7-18%
  • fetal mortality 9-23%
  • if survive, usually full recovery
25
Q

most common cause of anemia in pregnancy? when to screen? how to tx?

A

Fe-deficiency

screened at initial prenatal visit and again at 26-28 wks

Fe supplementation

26
Q

symptoms and tx of superficial thrombophlebitis in pregnant woman?

A

symptoms: swelling, tenderness
tx: bed rest, pain meds, local heat, no need for anticoag, wear support hose

27
Q

symptoms of DVT? Dx? Tx?

A

symptoms: more common in left leg than right, pain in calf with dorsiflexion (Homanns sign), may also have dull ache, tingling, or pain with walking

Dx: clinically difficult (50% are asymptomatic), compression US with doppler flow, MRI may be used if suspect pelvic thrombosis

tx: anticoag tx should be initiated when clinically dx
- use LMW or UFH –> follow aPTT values with Heparin and Factor Xa values w/LMW to assure therapeutic values
- Coumadin used for 6 wks postpartum but NOT during pregnancy d/t risk of fetal hemorrhage or teratogenesis (Follow INR)

28
Q

symptoms of PE? signs?

A

symptoms: pleuritic chest pain, short of air, air hunger, palpitations, hempotysis
signs: tachypnea, tachycardia, low grade fever, pleural friction rub, chest splinting, pulm rales, accentuated pulm valve 2nd heart sound

29
Q

evaluation of PE? tx?

A

Eval: EKG, CXR, ABG, VQ scan, helical CT

tx: Anticoag (Lovenox then heparin)

30
Q

what do pts with DVT or PE have to get worked up for?

A

thrombophilia work up –> lupus anticoag, anticardiolipid Ab, Factor V leiden, Protein c and s, ATIII, Prothrombin G20210A

31
Q

severe asthma associated with increase in?

A
miscarriage
preeclampsia
intrauterine fetal demise
intrauterine fetal growth restriction
preterm delivery
32
Q

most common type of HA in pregnancy? how to tx?

A

Tension –> tx with acetaminophen

33
Q

which anti-seizure med is more teratogenic than the others? which anti-seizure meds most commonly used?

A

valproate

most commonly used seizure meds are dilantin and phenobarbital

34
Q

how long after giving birth should you be concerned for postpartum depression if the mother is depressed after giving birth?

A

2 weeks post-birth