Tuesday, 2-28-Medical conditions in pregnancy (Wootton) Flashcards
when do you screen for Gestational DM? How do you screen?
24-28 weeks
50 gm 1 hr oral load glucose challenge test –> if abnormal followed by a 3 hr 100 gm oral load glucose tolerance test
risk factors for GDM development?
- fat
- previous hx of GDM
- strong FH of DM
- known glucose intolerance
maternal complications of GDM?
- increase risk of gestational HTN
- increased risk of preeclampsia
- greater risk of C section
- increase risk of developing diabetes later
fetal complications of GDM?
- MACROSOMIA
- neonatal hypoglycemia
- hyperbilirubinemia
- operative delivery
- SHOULDER DYSTOCIA
- birth trauma
maternal complications of Pregestational diabetes?
worsening nephropathy and retinopathy, increased risk of developing preeclampsia, greater risk of DKA
fetal complications from pre gestational diabetes?
increase risk of spontaneous abortions, anatomic birth defects (sacral agenesis), fetal growth restriction and prematurity
with good glycemic control, fasting glucose should be less than __ mg/dl, 2 hour postprandial glucose less than __ mg/dl
fasting < 90
2 hr postprandial <120
maternal evaluation for antepartum mgmt of preexisting diabetes?
renal-24 hr collections every trimester
cardiac-EKG
ophthalmic-detailed eye exam in 1st tri
glycemic control-monitor daily fingerstick glucose values and HgBA1C
fetal evaluation for anterpartum mgmt of preexisting diabetes?
early dating US
BCHEM testing for congenital malformations at 16-20 wks
fetal testing (NST/BPP) every week starting 32-34 wks
at what US-estimated fetal weight would you want to recommend caesarean delivery?
4500 gm
how to dx maternal hyperthyroidism?
elevated free T4 and suppressed TSH
When to use methimazole and/or PTU for maternal hyperthyroidism?
methimazole in 2nd and 3rd trimester –> can cause aplasia cutis and choanal atresia in 1st tri
PTU in 1st trimester only –> increased risk of liver toxicity if beyond 1st tri
monitor levels of what throughout pregnancy with maternal hyperthyroidism?
TSH
signs and symptoms of thyroid storm? tx?
s/s: hyperthermia, tachy, perspiring, high CO failure, maternal mortality rate of ~25%
tx: B-blockers (propanolol)), block secretion of thyroid hormone (Na iodide), stop synthesis of thyroid hormone (PTU), halting peripheral conversion of T4 to T3 (dexamethasone), replace fluid loss, bring temp down
increased risk associated with untreated maternal hypothyroidism? tx? monitor what monthly?
increased risk: spontaneous abortion preeclampsia abruption low birth weight infants stillbirth low intelligence
tx: thyroid replacement, i.e., Levothyroxine
monitor TSH and free T3/4 levels monthly