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Renal > Tubular Resorption > Flashcards

Tubular Resorption Flashcards

1
Q

What pumps that creates the charge and ion gradient?

A

Na+K+ATPase

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2
Q

Where does sodium linked co-transport of glucose, amino acids and phosphate occur?

A

Proximal convoluted tubule

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3
Q

Is proximal convoluted tubule water permeable?

A

Yes

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4
Q

How are water and Na+ reabsorbed in proximal convoluted tubule?

A

Leaky intercellular junction

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5
Q

Where are most of solutes reabsorbed in loop of Henle?

A

Thick ascending loop of Henle

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6
Q

Is thick ascending loop of Henle water permeable?

A

No

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7
Q

What is co-transporter on luminal surface in thick ascending loop of Henle?

A

Na+K+2Cl-

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8
Q

What are ions reabsorbed via paracellular diffusion in loop of Henle?

A

Na+ K+ Mg2+ Ca2+

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9
Q

Is early distal convoluted tubule water permeable?

A

No

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10
Q

What co-transporter is on luminal surface in cortical diluting segment?

A

Na+Cl-

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11
Q

What are two types of cells in collecting duct?

A
  • alpha and beta intercalated

- principal

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12
Q

Is Na+ reabsorbed into principal cells?

A

Yes

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13
Q

Is K+ reabsorbed into principal cells?

A

No

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14
Q

What hormone controls channels in principal cells?

A

Aldosterone

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15
Q

What is function of alpha intercalated cells?

A

H+ excretion

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16
Q

How is H+ excreted in collecting duct?

A
  • H+ pump (active transport) on luminal membrane

- K+/H+ exchanger on luminal membrane

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17
Q

What exchanger is on basolateral membrane of alpha intercalated cells?

A

Cl-/HCO3- exchanger

18
Q

What is function of beta intercalated cells?

A
  • Reabsorption of H+

- Excretion of HCO3-

19
Q

What pump and exchanger located on beta intercalated cells?

A
  • H+ pump on basolateral membrane

- Cl-/HCO3- on luminal membrane

20
Q

What are different isoforms of aquaporins?

A

AQP1-4

21
Q

What isoforms of aquaporins are constitutively expressed on basolateral membrane of collecting duct?

A

AQP 3/4

22
Q

What isoform of aquaporin is expressed on luminal membrane under control of ADH?

A

AQP 2

23
Q

Where is AQP 1 located?

A

Proximal tubule

24
Q

Where does countercurrent multiplier occur?

A

Thick ascending loop of Henle

25
Q

In countercurrent multiplier, does thick ascending loop of Henle pump NaCl into interstitium?

A

Yes

26
Q

In countercurrent multiplier, what happens at descending loop of Henle?

A

Water moves out

27
Q

Where does countercurrent exchange occur?

A

Vasa rectae

28
Q

In countercurrent exchange, does water move in/out in descent?

A

Out

29
Q

In countercurrent exchange, does salt move in/out in descent?

A

In

30
Q

In countercurrent exchange, does salt move in/out in ascent?

A

Out

31
Q

In countercurrent exchange, does water move in/out in ascent ?

A

In

32
Q

What two parts of nephron are permeable to urea?

A
  • Thin descending/ascending loop of Henle

- Medullary (not cortical) collecting duct

33
Q

What controls urea permeability in medullary cortical collecting duct?

A

ADH

34
Q
  1. Urea in ___ collecting duct is concentrated by removal of ___in upstream ___collecting duct.
  2. This creates a ___gradient between luminal urea concentration in ___collecting duct and adjacent___
  3. When ___ increases urea permeability in ___ collecting duct, urea moves ___ adjacent ___
  4. Urea in ___ is increased in concentration with respect to concentration of urea in thin ___/___
  5. Urea moves into tubular fluid of _____
A
  1. medullary, water, cortical
  2. concentration, medullary, interstitium
  3. ADH, medullary, into, interstitium
  4. interstitium, descending/ascending loop of Henle
  5. Loop of Henle
35
Q

Where does SGLT2-inhibitor act in nephron?

A

Proximal convoluted tubule

36
Q

What is function of SGLT2-inhibitor?

A

Bind to and inhibit glucose/sodium symporter

37
Q

An example of loop diuretics

A

Frusemide

38
Q

Where does loop diuretic act in nephron?

A

Na+K+2Cl- in loop of Henle

39
Q

What is function of loop diuretic?

A

Increase urinary loss of:

  • sodium
  • potassium
  • magnesium
  • calcium
40
Q

What is function of Thiazide diuretics?

A

Block NaCl cotransporter in cortical collecting duct

Renal (5 decks)

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