Tuberculosis

Question 1

Drugs used in intial phase of TB infection

Answer 1

Rifampicin, Isoniazide, Pyirazinamide and Ethambutol (+pyridoxine)

Question 2

How long should the inital phase of TB drugs be given for?

Answer 2

2 months, then 4 months of continuous phase

Question 3

what drugs are used in the continuation phase of TB

Answer 3

Rifampicin + isoniazid

Question 4

What is the total treatment length for extrapulmonary TB

Answer 4

12 months

Question 5

What is the test for laten TB

Answer 5

Mantoux skin test (+ CXR)

Question 6

When would you offer chemoprophylaxis to a laten TB patient?

Answer 6

If they are a HCP, close contact of an active TB patient, immuncompromised –> give 6 months isoniazide or 3 months isoniazide + rifampicin

Question 7

Rifampicin counselling

Answer 7

Discolours soft contact lenses, turns sectrions orange-red, report sx of hepatic disorders

Question 8

monitoring of Rifampicin

Answer 8

renal function, hepatic function, FBC

Question 9

What are Aminosalicylic acid, Bedaquiline, capreomycin and cycloserine used for?

Answer 9

MDRTB

Question 10

Side effect of Isoniazid

Answer 10

peripheral neuropathy (give pyridoixine alongside) q

Question 11

Monitoring with isoniazid

Answer 11

Acetylator status - slow = inreased risk of peripheral neuropathy, renal and liver function

Question 12

Monitoring associated wiht Ethambutol

Answer 12

Visual acuity, renal function

Question 13

Monitoring wiht Pyrazinamide

Answer 13

renal and hepatic function