Tuberculosis Flashcards

1
Q

what causes TB?

A

Mycobacterium TB- aerosol droplets

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2
Q

how many people will develop dz?

A

most exposed will mount an immune response that is sufficient to prevent progression

but 10% will- “Primary TB”

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3
Q

what happens when a person can’t contain the primary infxn?

A

progresses to active TB w/in 2 yrs

“progressive primary TB”

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4
Q

what is a “latent TB infx”?

A

“LTBI”

those that contain the
bacterium w.o become infected-

they are not considered to be infx, nor can they spread the dz

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5
Q

where is inactive TB most commonly found in the body?

A

apices of the lung

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6
Q

what is “reactivation TB”?

A

develops from LTBI in the setting of immune compromise

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7
Q

what is the most common sx of TB>

A

cough

dry cough and progesses to a productive cough
+/- hemoptysis that last longer than 3 wks

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8
Q

what are other sx?

A

cough, pleuritis chest pain, fever, night sweats, anorexia, weight loss

**posttussive rales

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9
Q

how might the pt appear?

A

chronically ill and malnourished

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10
Q

Laboratory findings of primary TB

A

homogenous inflitrates, hilar/paratracheal lymph node enlargement, segmental atelectasis, cavitations w/ progressive dz

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11
Q

XR or reactivation TB

A

fibrocavitary apical dz, nodules, infiltrates, posterior and apical segments of the Right upper lob, apical-psterior segments of the left upper lob, superior segments of the lower lobs

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12
Q

healed primary infx show what on the xra?

A

ghon and ranke

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13
Q

ghon complexes

A

calcified primary focus

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14
Q

Ranke complexes

A

calcified primary focus and calcified hilar lymph nodes

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15
Q

PPD?

A

reported accourding to the diameter of INDURATION

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16
Q

ppd read?

A

> 15mm-pts w/ no rf for tb

> 5mm-pts w/ active HIV

17
Q

definitive dx of TB

A

identification of myco. TB from cultures or b by DNA/RNA amplification techniques

18
Q

what is the histologic hallmark?

A

bx revealing caseating granulomas

19
Q

how do you tx TB?

A

isoniazid
rifampin
pyrazinamide
ethambutaol

20
Q

ADR of isoniazid?

A

hepatitis, peripheral neuropathy

*coadminister vit B6 to reduce risk

21
Q

ADR of rifampin?

A

hepatitis, flu syndrome, orange body fluid

22
Q

ADR of ethambutaol

A

optic neuritis

23
Q

how long to you tx ps w/ active dx for?

A

6-9 mnts, pts w/ HiV requires at least a year

24
Q

what is the bacille Calmette-Guerin vaccine?

A

use in aread where TB is endim

25
Q

what about kids and immunocompromised that have been in close contact w. active TB?

A

offer tx until TST is neg 12 wks after exposure