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GHHM > Tuberculosis > Flashcards

Tuberculosis Flashcards

1
Q

Strongest known risk factor for developing TB.
What’s the estimated relative risk?
Any other risk factors?

A

HIV
20
Age, DM, ETOH, Smoking, malnutrition

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2
Q

TB Lymphadenitis main ddx
What’s characteristic of TB?

A

Lymphoma, HIV
Rubbery, non-tender, necrotic area allowing aspiration, asymmetrical, paradoxical enlargement with treatment

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3
Q

True or False: Two sputum specimens obtained in the clinic are as sensitive as two samples taken on separate days

A

True

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4
Q

True or False: The concentration of bacteria in a smear gives a guide to burden of disease and infectivity of the patient

A

True

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5
Q

Which diagnostic method is the gold standard for TB?

A

Culture - but takes several weeks

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6
Q

What else can original geneXpert tell you other than a diagnosis of TB?

A

Resistance to Rifampicin

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7
Q

Pros of GeneXpert?

A

Rapid, does not require technical experties

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8
Q

Other types of geneXpert?

A

Ultra : higher sensitivity
Omni: Battery operated

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9
Q

Side effects: R, INH, Z

A

Liver dysfunction, rash, GI upset

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10
Q

Side effects: Rifampicin, RifaPentin

A

Major drug interaction including OCP

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11
Q

Side effects: INH
What reduces its risk?

A

Peripheral neuropathy
Vit B6

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12
Q

Side effect: Pyrazinamide

A

Arthralgia

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13
Q

Side effect: Ethambutol

A

Optic neuropathy (Careful with kidney disease)

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14
Q

MDR TB definition

A

Resistance to Rifampicin and Isoniazid

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15
Q

Pre- XDR TB

A

MDR + flouroquinolone

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16
Q

XDR TB:

A

MDR + fluoroquinolone + at least one Group A drug (Bedaquiline & Linezolid)

17
Q

Risk factors for MDR-TB

A
  • Contact of a known case of MDR TB
  • Previous drug treatment for TB
  • Poor adherence to previous treatment
  • Birth or residence in a country with WHO-reported incidence of =/> 5% of new cases
18
Q

Treatment MDR-TB

A

3A +1B
(levofloxacin OR moxifloxacin) OR bedaquiline OR linezolid + clofazimine OR cycloserine OR terizidone
For 20 months

19
Q

Which TB drug should you be worried about giving to a patient on OCP?

A

Rifampicin

GHHM (2 decks)

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