Tuberculosis Flashcards
mycobacterium are fast or slow growing microbes?
slowwww
2 ways to test for latent TB
- PPD skin test
2. blood tests (quantiferon gold*)
tx for latent TB
3 tx:
- isoniazid (daily 6-9 months)
- isoniazid + rifapentine (q week for 12 weeks)
- rifampin (daily 4 months)
considering the 3 recommended tx for latent TB and dosing, what tx is most likely to have increased adherence?
isoniazid + rifapentine b/c 12 total doses vs hundreds!
risk of treating active TB with isoniazid only…
could lead to resistant bacteria
action of isoniazid on actively dividing mycobacterium
bactericidal
action of isoniazid on resting/dormant mycobacterium
bacteriostatic
what 4 drugs are typically given as INDUCTION therapy for active TB?
- isoniazid
- rifampin
- pyrazinamide
- ethambutol
when would we use 2nd line drug therapy for TB?
when TB becomes resistant to 1st line drugs
MDR-TB is resistant to which 2 drugs?
isoniazid + rifampin
XDR-TB is resistant to which drugs (4)?
isoniazid + rifampin + fluroquinolones + at least 1 injectable 2nd line
goal of induction phase tx for TB
get rid of ACTIVELY dividing extracellular bacilli to MAKE SPUTUM NONINFECTIOUS
goal of continuation phase tx for TB
eliminate persistent intracellular bacilli
TB meds that cause hepatotoxicity
- isoniazid
- rifampin
- PZA (pyrazinamide)
TB med with major SE of optic neuritis
ethambutol
= blurred vision, can’t discriminate colors
TB med that can turn excretions orange-red color
rifampin
B6 given to prevent peripheral neuropathy with this TB drug
isoniazid
“ISO tingly I’m buzzing like a B”
TB meds to avoid with liver disease or ETOH use
- isoniazid
- rifampin
- PZA (pyrazinamide)
should use another form of BC with this TB med
rifampin
TB meds to have liver enzymes checked with
- isoniazid
- rifampin
- PZA
DON’T give this TB med with food (decreases absorption)
rifampin
drug-drug interactions with HIV meds with this TB drug
rifampin
should give routine eye exams with this TB med
ethambutol (optic neuritis risk)
after tx for active TB, patients should see improvement with clinical manifestations in _________ (time frame)
2 weeks
after tx for active TB, CXR should improve within _______ (time frame)
3 months
after tx for active TB, sputum cultures should become negative in most (90%) patients in ______ (time frame)
3 months
