Trypanosoma Leishmania

Question 1

Heteroxenous

Answer 1

More than one host in lifecycle

Question 2

Both T & L

Answer 2

One stage lives in vertebrate host blood/body fluids or tissues
Another stage lives in gut of bloodsucking insects

Question 3

African Trypanosomiasis

Answer 3

Trypanosoma Brucei

subspecies: T.B Gambiense (west africa) and T.B Rhodesiense (east africa)
- causes african sleeping sickness

Question 4

American Trypanosomiasis

Answer 4

Trypanosoma Cruzi

-causes chagas disease

Question 5

African T: Hosts

Answer 5

-Tstetse flies are intermediate host and wector
-Verterbrate host are humans
trypanosome and trypomastigotes inhabit the blood,lymph, and cerebrospinal fluid
-Parasite stages live in extracellular fluid

Question 6

Trypanosoma Brucei subspecies LIFECYCLE

Answer 6

Human Stages:
1. Tsetse fly takes blood meal
2. Injected trypomastigotes transform into bloodstream trpos and are carried throughout
3. Trypom. multiply by binary fission
Tsetse fly stages
5. Tsetse fly takes a meal
6. Bloodsteam trypom. transform into procyclic trypom. then multiplies by binary fission
7. Procyclic Trypom. leave midgut and transform into epimastigotes
8. Epimastigotes multiple in salivary gland, transform into metacyclic trypom.

Question 7

Trypanosoma Brucei

Answer 7

• Sore at sight of insect bite
• Parasitemia. fever throughout body
• swollen lymph nodes

Question 8

T.B Rhodesiense

Answer 8

• MORE LETHAL (few months)
• weight loss
• heart complications
• death

Question 9

T.B Gambiense

Answer 9

-invades nervous system

apathy, tremors, convulsions, paralysis, coma, death (sleeping sickness)

Question 10

African Tryp: Treatment

Answer 10

Arsenic-“magic bullet”

Suramin