Truelearn Flashcards
primary hyper pth most commonly from….
what if localization studies are negative
primary adenoma single in 85%
prepare for bilateral neck exploration
Inclusion and exclusion criteria for superficial surgical wound infections
Malignant hyperthermia:
rec mutation?
inh pattern?
usual inciting medicaiton?
Other SEs of this medication? tx? MOA of med?
ryanodine receptor
AD
sux
hyperkalemia; dantrolene; depolarizing muscle blockade
Pt populations to hold succinylcholine in ?
closed head trauma, burns, NM disease
Standard approach for popliteal aneurysms?
Standard operation?
medial
exclusion with ligation and bypass with GSV
describe RAAS components
4 classes of pilonidal disease
what PFTs must be met prior to pneumonectomy?
Lung resection?
fev1>80, DLCO>60, FEV1 >2L
Hypermagnesemia severe range?
EKG changes?
Tx?
> 12
Pr interval prolongation
Ca; hydration and diuresis
best test for elderly hip pain after fall
CT
2 things that change goiong from class 3 to 4 shock?
lethargy/obtunded and absent uop
atypical ductal hyperplasia has a —-% chance of harboring in situ or CA
15-30
MC presentation and mammogram finding for DCIS
clustered microcalcs
in what order do cell types show up in wound healing? approximate times?
Platelets - immed
Neutrophils - 24-48 —-cytokines, debris
Macroghages - 48-96
Lymphocytes
Fibroblasts
3 stages of wound healing and predominant cell types
inflam -1-7d - neutrophils, mps, lymph
prolif - 3d-3wk –all
recon - 3wk - fibroblasts
2 collagens in wound healing, when they show up and which is left?
3 and 1; 3 spikes in prolif and then 1 takes off and stays; fibronectin is also around
what margins are required for a cancerous polyp snaring to be definitive
2mm margins with no base involvement
wound classes and their % chance of SSI
when and what multiple of amylase abnormality needs to be present to define panc leak
POD3 x 3
differences between the vasculature of the adrenals
inf phreni, aorta and renal feed arterial supply b/l
right adrenal vein goes to IVC
left adrenal vein goes to left renal
4 s/s of hypocalcemia?
perioral numbness
chevstock - cheek tap
Troussea -BP cuff and carpopedal spasm
prolong qt
pancreatic injury grading
confirmatory study for ischemic colitis
scope
why altmeir of delorme in necrotic prolapse?
delorme just strips mucosa, may not see all full thickness
sensitivity?
ppv, npv?
specificity
amphotericin B MOA?
AE?
binds to fungal cell wall sterols
nephro
fluconazole MOA
AE
cell wall synth inhibit
capsofungin moa
D B glucan synthase inhibition
felon vs paronychia appearance?
MC bug?
definiive tx for felon and why is this so seriosous
felon is in volar pulp v infection under nail bed
staph
I&d —- 75% necrosis possible
max ligasure vessel size
7MM
visceral Blood vessel diameters
splenic - 5mm
cha - 6mm
rha - 3mm
celiac - 8mm
sma - 8mm
ima - 5mm
MCC of cushing syndrome? endo v exo v overall
What is cushing disease
cush dis v steroids v steroids
pit tumor – ACTH secreting
3 burn meds and their SEs
All sepsis pressors and their MOAs + receptors
what other deficiency can hypomagnesemia cause?
Calcium
GB cancer staging and next steps
what defines unresectable GB cancer
PV or hepatic artery
2 or more organs
Differing features among crohns and uc
crypt abscesses in uc, only colon and rectum, only mucosa and submucosa
burn grades and appearances
how does desmopressin work?
what if that does not work for uremic bleeding
increases factor 8 and vwf
dialysis
transfusion reaction types and their treatments
BIRADS?
what birads do we start biopsies
4
cushing diagnosis flow chart
Tx for branchial cleft cyst if infection concerns
always delay surgery, tx with abx in the meantime
tx of biliary injury iatrogenic and trauma
A single duct < 3 mm in size identified on cholangiography, draining a single segment/subsegment of liver can be primarily ligated; 4 mm or greater generally requires repair.
< 50% circumference injury, non-electrocautery: primary repair with 4-0 or 5-0 absorbable suture, placement of T-tube
> 50% circumference injury OR electrocautery: biliary-enteric reconstruction, typically Roux-en-Y choledochojejunostomy vs choledochoduodenostomy
What is involved in a superficial inguinal nod dissection?
when should a deep dissection be performed for melanoma?(3)
what is cloquets node
femoral canal nodes
cloquets is pos, large numbe of superficial nodes pos, or imaging concerns
what is the next step after deep inguinal node dissection
4 cancers associated with EBV
burkit lymphoma, gastric ca, nasopharyngeal, hodgkins
what cancers are assoc with li fraumeni
gene?
tp53
How to cover former trach site after repositioning pos innominate ligation
local strap muscle flap
preferred reversals for anticoags in head trauma
inflammatory breast cancer criteria
MC complication of hepatic trauma
bile leak
tx for symptomatic hemangioma in child
MC suppurative thrombophlebitis bug
staph aureus
normal systemic periph vasc resist. numbers?
what are elevated peak pressures?
700-1500
40
What must be repleted first in an altered gastric bypass patient with dehydration 6 weeeks later
thiamine as it is absorbed in the duo and jejunum
what incision do you choose for sma arteriotomy and why
transverse with healthy vessel
longitudinal if unhealthy and patch may be needed
How are sb hemangiomas dg and how should they be managed
CT IV
no intervention if asymptomatic
endo or IR can control bleeding
surgery if all else fails
2 most common sites for peripheral artery aneurysmsative sizes?
Pop then CF
2 and 2.5
CDH1 prophylaxis timing?
total gastrectomy 18-30 and screen like BRCA
what is the mc electrolyte abnormality in SBO
mechs?
so what type of fluid are you giving
hypok hypo cl met alk
vomiting Cl and H leads to higher bicarb in blood
RAAS tries to retain H and drops K
LR balanced
MCC of intussusception in adults
Ca
4 common bugs in SB overgrowth
4 structures that predispose
streptococci, bacteroids, Escherichia coli, and lactobacillus.
blind loops, fistula, larg divert, stricture
what can be seen on cbc for SB overgrowth patients and why?
B12 deficiency due to bacteria overconsumption
testing for sb overgrowth
imaging?
labs?
A d-xylose test (carbohydrate breath test) is useful. The metabolism of carbohydrate substrates from bacteria leads to the production of hydrogen and/or methane, which is detected in the breath.
Cross-sectional imaging may serve to delineate anatomy if blind loops or strictures are present.
Laboratory findings include low vitamin B12, thiamine, and niacin levels, with high serum folate and vitamin K levels.
non op tx for sb overgrowth
MOA and duration
rifaximin
DNA dep RNA poly; 14 d
supplements for blind loop patients
B12 and med chain FA
2 most important surgical anatomy factors in optimizing short gut
how do these help
keeping IC valve and ileum
ICV allows for transit control
Ileum absorbs ADEK, B12 and bile acids; most adaptable
compare ileum and jejunum
4 instances of TPN failure in short gut
Parenteral nutrition–associated liver disease
Loss of central venous access (ie, loss of three to six central venous access sites in children or two to four central venous access sites in adults)
Recurrent catheter-related sepsis or a single episode of fungal sepsis
Recurrent bouts of severe dehydration or metabolic abnormalities
absolute contraindication to SB transplant
Active infection or malignancy
3 long term complications with short gut outside of intestine
Calcium oxalate kidney stones and gallstones
Hepatic and biliary disease
Metabolic bone disease
alternate PE findings for appendicitis
Rather, patients with a retrocecal appendix will often have a positive psoas sign (pain with active flexion of the right hip), whereas patients with a pelvic appendix will often have a positive obturator sign (pain with passive adduction of a flexed right hip).
For appy, what causes luminal obstruction in kids v adults
MALT v fecelith
median age of appendicitis
28
assoc disease with appy
CF
Appy ddg in women
pelvic inflammatory disease, adnexal cysts, ovarian torsion, ectopic pregnancy, or a tubo-ovarian abscess should be considered.
percent of pop with appy
6%
All the appy PE signs
negative appy risk for pregnancy
Negative appendectomy is associated with a 4% rate of fetal loss and a 10% rate of early delivery.
considerations in interval appy
An underlying mass should be excluded with colonoscopy in appropriate patients.
Delayed appendectomies are recommended for two reasons: to prevent the recurrence of appendicitis and to exclude neoplasms within the appendix or cecum.
The incidence of appendiceal neoplasms at appendectomy is approximately 1% to 1.5% and increases after age 40. This risk should be weighed when considering interval appendectomy.
Lap appy risk %s
Patients undergoing laparoscopic appendectomies have a 1.2% chance of requiring conversion to open operation, a 0.7% risk for intraoperative complications, and a 1.5% risk for postoperative complications.
Describe toxigenesis of C diff
Toxigenic strains produce two toxins, A and B, which cause mucosal injury and increased fluid secretion from colonic enterocytes, in turn causing the characteristic watery diarrhea seen in active infection. Toxin B is more than 10 times as potent as toxin A.
Localized necrosis of the mucosa and the subsequent inflammatory cascade lead to the formation of pseudomembranes on the mucosal surface, which are localized collections of cellular inflammatory debris.
What hx should be asked if concern for c diff
Workup for C difficile colitis is indicated for patients with clinically significant watery diarrhea (>3 episodes in 24 hours), recent antibiotic use (most commonly within 2 weeks prior to the onset of symptoms), recent hospitalization or residence in a health care facility, or a known history of C difficile infection.
first line test for c diff; whats the issue
next?
stool toxin, false negatives
NAAT — looks for gene encoding toxin B
concerning colonic measurements in c diff
colon> 6cm
cecum>12
2 labs for severe c diff
15k wbc or 1.5 cr
what may be a harbringer of worsening c diff colitis?
this is secondary to….
worsening ileus; colonic atony
mortality and stoma reversal rates with c diff colectomy
preferred operation?
Mortality rates for C difficile colitis requiring surgery are greater than 50%.
Stoma reversal rates are less than 35%.
total
recurrent c diff recs: 1st 2nd 3rd
For the first recurrence: pulse-tapered oral vancomycin or oral fidaxomicin is indicated if the infection was initially treated with vancomycin. If it was initially treated with fidaxomicin or metronidazole, oral vancomycin is indicated.
For the second recurrence: longer courses of vancomycin, fidaxomicin, rifaximin, and/or combinations thereof are indicated.
Consider fecal microbiota transplant in patients with multiple recurrent C difficile infections despite multiple rounds of adequate therapy.
inpatient acute c diff colitis mild, severe and fulminant medical txs
what if ileus is present?
mild: oral vanc or fidaxomycin
sev: same
fulm: oral vanc and IV metro
rectal vanc enemas for ileus
tracking for C diff incidence
The Centers for Medicare & Medicaid Services requires that all acute care hospitals, long-term care facilities, and inpatient rehabilitation facilities report C difficile infections via the National Healthcare Safety Network run by the Centers for Disease Control and Prevention.
Laboratory-positive infections must be reported, as well as the patient’s location at the time of positive specimen collection. Data are collected from inpatient units, emergency departments, and 24-hour observation units (ie, clinical decision units).
What therapy is given after all mastectomies and lumpectomies?
What are the benefits?
WB rads
dec local rec
inc survival
4 patients that cant get breast cons therapy for DCIS
1st tri preg
diff pos margins
small breasts
diffuse susp calcs
MC complication of PEG tube
infection
Tx for any solid intratesticular mass?
radical orchiectomy
What are the 3 antigen presenting cells and which one predominates
Dendritic
mp, B cell
kupffer cells
liver Mps
NK cells attack cells that lack what
MHC1
IL for B cells
4
Reboa zones and where not to occlude
Single bx for barretts confirms high grade, what now
tx
4 quad bx every 1 cm
EMR
MCCx of hemorrhoidectomy and why
urinary incontince
-ivf
-pain irritating nerves
-adv age
Signs concerning for primary graft non function for liver tx
tx
re trans
First line tx for acute rejection of transplant
2nd?
steroids
anti-thymocyte globulin
Mondor dis primary cause
secondary?
idiopathic
trauma, iatrogenic, infection, ca, hypercoag, vasculitis
MCC of suppurative jugular vein thrombo
pharyngitis
Dg imaging for colovesical fistula
CT
MC side of dissection in type B
posterolateral
Gastric NET endoscopic resection cutoff?
2cm as 10% nodal mets at that point
tracheal injury mng:
1. small anterior defects
2. transection(howmany rings can be lost?)
3trach?
- simple transverse
- 6
- Devastating injury
positive predictors for successful reflux surgery
typical gerd signs
demeester appropriate
good response to ppi
ca in celiac patients
enteropathy assoc t cell lymphoma
MCC of liver failure in US?
tx?
acetam
n-acetyl
do i have to tell patients im HIV pos?
not legally, but ethically
MC long term sequelae of ileal pouch
pouchitis
preferred graft type in sma bypass
PTFE
measurement cutoffs for arteries and veins for fistula formation wrist?
upper arm?
2mm artery and 2-3mm veins
3?
rule of 6s for av fistula formation
When can a pregnant woman get rads for breast ca?
what would she receive otherwise if operative
2nd and 3rd
simple mastectomy and SLNB
What is the proven benefit of a trach
less sedation to aid in weaning
3 mechs of PTH ca inc
- osteoclast stim
- stim calcitriol(VD) formation
- DCT rabsorb in kidney
3 MC bugs in SBT
e coli, kleb, pneumococc
Most important vitamin in wound healing
3 mechs
collagen cross linking
makes hydroxyproline
stabilizes collagen
what is a positive apnea test?
pCO2 rises to 60 off vent
combined invasice breast ca and DCIS tumor margin rules
negative ink is good
why 2mm for DCIS
skip lesion
location for thoracentesis
8th midax and mid scap
In patients with hematochezia and hypotn what must be ruled out
UGIB
absolute indications for dialysis
relative?
uremic pericarditis, pleuritis, encephalopathy
AEIOU
mid shaft humoral fracture is associated with what nerve injury
radial
radial , median and ulnar distal ue motor actions?
radial - thumb and wrist ext
median thumb and wrist flex
ulnar - all pinky stuff
early vs late graft infection bugs
aureus vs epidermidis
2 parts of treatment for TTP?
steroids and plasmapheresis
give new ADAMTS3 while suppressing further destruction by immune system
2 GIST grade determinants
when should warfarin be bridged for surgery concerning AF stroke risk
what trial supports this
CHADSVASC of 3
BRIDGE trial
MCC hepatits in west vs east
Western is B
Eastern is C
Do any superficial vein thrombi need anticoag?
3 cm from saphenousfemoral junction