True Learn Flashcards
Most common papillary muscle that causes mitral regurgitation post MI? What blood supply?
Posteromedial pap
RCA
Symptoms of MH
Increase in ETCo2
Peak T waves
Lactic acidosis
Muscle rigidity
What’s the earliest you can restart px heparin after an uncomplicated epidural placement
Immediately
(Wait w placement or removal of catheter, immediately start after placement or removal)
What’s the most common complication of a celiac plexus block
Orthostatic hypotension and diarrhea
Reflexive movement as a response to surgical stimulus
(What level of anesthesia)
General
Safest flow meter arrangement
W oxygen closest to the patient/ most downstream
What would you expect pulse ox to read in someone w methemoglobinemia
85%
What cardiac anomaly is most common in carcinoid tumor?
Tricuspid regurgitation
Tricuspid stenosis (much less common)
Carcinoid triad
Wheezing
Flushing
Right heart dx
Volume compartments
Interstitial > intravascular
Intracellular = extracellular
Shunt fraction
Qs / Qt = (1n− SaO2) / (1 − SvO2), where Qs = pulmonary physiologic shunt, Qt = cardiac output, SaO2 = arterial oxygen saturation, and Sv02 = venous oxygen saturation
Alveolar oxygen equation
PaO2 = FiO2 × (Patm − PH2O)−(PaCO2 / R)
FiO2 = Fraction of inspired oxygen
Patm = atmospheric pressure = 760 mmHg
PH2O = partial pressure of water vapor = 47 mmHg
R = constant = 0.8
Who qualifies for early invasive cardiac strategies?
Worsening underlying heart disease
- recurrent angina or ischemia at rest
- elevated cardiac bio markers
- new ST depression
- new or worsening mitral regurgitation
- hemodynamic instability
- sustained tachy
- pci within 6 mos
- prior coronary artery bypass
- high risk TIMI score > 2
- reduced left ventricular function
What is appropriate management of epiglottitis in a pediatric patient
DL under deep GA
What are the benefits of smoking cessation and what is the optimal time for quitting?
Decrease carboxyhemoglobin levels
Increase in ciliary function
Decrease in sputum production
Decrease in stimulation of the cardiovascular system
8 weeks
*reduction in carboxyhemoglobin shifts the oxygen dissociation curve to the right = more oxygen unloading
What’s the order of invasive accretas
Accreta
Increta
Percreta
How does lidocaine cause fetal acidosis
Lidocaine crosses the placenta and accumulates to toxic levels due to ion trapping
What are the four factors that determine placental transfer of drugs
Size : <500 Da
Lipophilicity: lipophilic cross (fentanyl), high ionized do not
Protein binding
Maternal drug concentration
What drugs do not cross the placenta
Heparin
Insulin
Glycopyrrolate
Nondepolarizing muscle relaxants
Sux
He is going nowhere soon
Most common cause of adrenal insufficiency in pts w critical illness
Functional adrenal insufficiency : causing corticosteroid def, due to cellular dysfunction, peripheral glucocorticoid resistance, and impaired transport
What causes the acid base status w NS infusion
Metabolic acidosis due to decreased strong ion difference
SID= strong cations - strong anions
SID takes into account HCO3, albumin, phosphate, unmeasured ions
In pt w cirrhosis and BP what is the most common cause of ARF?
Type 1 HRS (acute renal failure from a precipitating event related to cirrhosis ; such as bacterial peritonitis)
Type 2 is an insidious onset of renal failure from portal htn caused by splanchnic vasodilation and activation of raas
What is the CAM-ICU assessment?
The CAM-ICU asks the following:
Is there an acute change in mental status or fluctuating course? (yes/no)
Is the patient inattentive or easily distracted? (yes/no)
Is there an altered level of consciousness or RASS other than zero? (yes/no)
Does the patient experience disorganized thinking? (yes/no)
Which drugs are unsafe agents to use in patients with MH?
- volatile anesthetics
- succinylcholine
What are the safe drugs to use in patients with MH
- barbiturates
- inhaled non-volatile anesthetics (NO)
- local anesthetics
- opioids
- non-depolarizing muscle relaxants
- benzos
What are the commonly used anesthetics used in ECT and what are their durations
Etomidate- increases seizure duration
methohexital/ ketamine- no/minimal effect on seizure duration
midazolam, propofol, lidocaine, and volatiles- decrease seizure duration
When does airway closure begin in patients with emphysema?
earlier/ closer to the alveoli
what is the dose for oral midazolam in pediatric patients
0.5mg/kg
IV is 0.05-0.1 mg/kg
What are the target sites for sympathetic cardiac innervation?
A1, B1, and B2
sympathetic cardiac innervation originates from T1-T4 and travel through bilateral stellate ganglions prior to ending as cardiac nerves
A1: positive inotropy
B1: positive chronotropy, domotropy (conductivity of a nerve), lusitropy (myocardial relaxation), and inotropy
B2: positive chronotropy > isotropy
What is extraction ratio?
fraction of drug removed from blood passing through the liver
which drugs have high liver extraction ratio?
bupivicaine, diltiazem, fentanyl, ketamine, meperidine, metoprolol, morphine, nifedipine, and propofol
these are flow dependent
what drugs have low hepatic extraction ratios?
diazepam, methadone, roc, alfentanil, and thiopental
What medication should be avoided in a thyroid storm?
salicylates (aspirin) because they compete with T3 and T4 for thyroid- binding globulin
signs and sxs of a thyroid storm
hyperthermia
hypertension, tachycardia, arrhythmia
mental status change
cardiovascular collapse
congestive hf in pts prone to hf
medications= PTU (more favorable) and methimazole and iodine after antithyroid drugs
what are the sympathetic block indications?
vascular: A/V occlusion, intra-arterial injection of irritants, raynauds, throboangiitis obliterans, vasospasm, venous insufficiency
neuropathic: acute herpes zoster, CRPS 1 & 2, phantom limb
visceral: abdominal cancer, chronic pancreatitis, refractory angina/ acute MI if medically indicated
What is the oculocardiac reflex
afferent: trigeminal nerve
efferent: vagus nerve causing Brady
Stimuli at the eye -> ciliary ganglion -> ophthalmic division of trigeminal nerve -> Gasserian ganglion -> trigeminal nucleus -> vagus nerve -> bradycardia.
What muscle layers are pierced in a TAP block?
EO and IO
local anesthetic is deposited in the plane between IO and transverses abdominis muscles
is mitral and aortic stenosis contraindicated in neuraxial anesthesia?
no
only severe aortic stenosis
mild to moderate aortic stenosis favors spinal anesthesia
how does Mac change in chronic and acute alcohol intoxication?
chronic- increases Mac
acute- decreases Mac
what’s the safest option of anesthesia in a pediatric patient undergoing pediatric radiation therapy?
propofol for deep sedation while maintaining spontaneous vent
how does intrathecal pumps decrease constipation
avoids first pass effects that you would see in chronic oral opioid therapy, which causes constipation
How do you manage the airway in patient’s with mediastinal masses?
maintained w SV w local and regional anesthesia techniques. Awake intubation and rigid bronch for advanced airway could be beneficial. Positioning in lateral decubitus is preferred to alleviate airway collapse from a supine position
how does abdominal surgery affect hepatic blood flow?
decreases, which will cause increase in liver enzymes
Venous compliance equation
change in venous volume/ change in venous pressure
- Angiotensin 2, endothelin1, increased sympathetic tone, Valsalva maneuvers, and inotropes decrease venous compliance
Uterotonic medications
Carboprost
Methylergonovine
Misoprostol
Oxytocin
Side effects of carboprost and contraindications
SE: bronchospasms and nausea
Contraindication: reactive airway disease
SE and contraindications in Methylergonovine
SE: hypertension, vasoconstriction, coronary vasospasms
Contraindicated: hypertension and preeclampsia
SE/ contraindications in misoprostol
SE: nausea and fever
no contraindications
Oxytocin
SE: hypotension, tachy, coronary vasoconstriction, MI
used for prophylaxis
What is sodium bicarb’s requirement to normalize pH?
0.2 x patient’s weight x base deficit
What cardiac changes do you see with abdominal insufflation
bradycardia, bradyarrythmias, and asystole
what are the prejunctional neuromuscular disorders
Charcot-Marie-Tooth and Friedreich ataxia
what are the postjunctional neuromuscular disorders
DMD, BMD, myotonic dystrophy, myotonia congenita (NNMBD do not alleviate contractures), hyper and hypoK PP
What are the metabolic neuromuscular disorders
metabolism and mitochondrial disorders
What is the major pulmonary pathophysiology of drowning
pulmonary washout of surfactant
o Drowning aspirate 3-4ml/kg of surviving victims
o 11ml/kg to change blood volume
o 22ml/kg to change electrolytes
how does acute cocaine affect mac
increases
treat acute cocaine toxicity w benzos
What meld score poses a risk on postop liver failure
> 10
> 14 is not considered for surgical intervention
How does the body compensate for increases in intracranial volume?
redistribution of intracranial venous blood and CSF to extracranial veins and spinal CSF space respectively
What procedure is commonly performed in pseudo tumor cerebri
lumbar puncture to improve visual disturbances
what cord level injury would you see in paraplegia vs quadriplegia
T1 and below = para
above = quadriplegia
How does TENS units work?
involves electrical stimulation of large diameter A-beta cutaneous mechanoreceptors. This inhibits signaling through A-delta and C pain fibers, closing a “gate”
what is the most common occurrence leading to a malpractice claim?
death - 29%
nerve injury - 21 %
brain damage - 9%
airway - 6%
Where is serotonin stored?
90% of the body’s serotonin is stored in the enterochromaffin cells in the gut wall; it is triggered by toxic substances like hypertonic saline and copper sulfate