Tricyclic antidepressants Flashcards
1
Q
MOA of tricyclic antidepressants?
A
-blocks the reuptake of monoamines
- mainly noradrenaline and 5 HT into presynaptic terminals
2
Q
side effects of TCA?
A
- anticholingeric
1- blurred vision
2- dry mouth
3- constipation
4- urinary retention - sedation
- weight gain
- cardiovascular
1- postural HTN
2- tachycardia
3- arrhythmias
4- cardiotoxic in overdose
3
Q
examples of TCA?
A
- imipramine
- dosulepin
- amitriptyline
- lofepramine