Trichomonas Vaginalis Flashcards
Trichomonas reproduces by……, its definitive host is……
Longitudinal binary fission
Human
What are the infective, pathogenic & diagnostic stages of Trichomonas
Trophozoite stage
What is the habitat of trichomonas?
In female: vagina, cervix, urethra, UB, Bartholin & Skene glands
In male: ant urethra, prostate, seminal vesicles
Describe mode of infection & infective stage of Trichomas?
- Sexual intercourse is the 1ry mode of transmission of trophozoite (infective stage)
- Occasionally, transmitted by toilet seats & fomites
- Rarely, mother to infant through birth canal
Describe pathogenesis of trichomoas
An obligate noninvasive parasite, causes contact dependent cytopatyic effect of target cells due to toxic & mechanical irritation, it produces proteases & a cell detaching factor that causes detachment of vaginal epithelial cells.
List Predisposing factors to Trichomonas
- Inc vaginal pH
- Superadded infection as gonorrhea
- Dec in IgA
Trichomonas vaginalis requires pH……
5.0-5.5
Mention factors that interfere with lactic acid production thus predispose to trichomonas
a. Dec in number of doderlein bacilli due to OCP,steroids, Abx
b. Hormonal disturbance
IP of trichomoas is….
5-28 days
Compare signs of trichomonas in males & females
M: white urethral discharge, enlarged tender prostate due to prostatitis
F: leucorrhea (creamy or yellow vaginal purulent frothy discharge with foul odour), strawberry vagina (hyperemia & petechial Hge)
List complications of Trichomonas
- Pregnant women may a..deliver prematurely, b..have low birth weight baby, c..transmit infection to baby
- Postoperative infections
- Cervical neoplasia
- Trichomonas vaginalis inc risk of HIV transmission
- In male, urethral stricture & infertility
Compare diagnostic specimen for Trichomonas in males & females
M: urine sediment, semen or prostatic secretion
F: vaginal swab or urine sediment
Fixed smears for Trichomonas are stained by….
Giemsa or Papanicolaou stain
Mention media for trichomonas
Modified Diamond’s medium or Trussel’s & Johnson’s medium
Drug of choice for Trichomonas is……., in pregnant women it is……
Oral metronidazole (Flagyl)
Suppository of Clotrimazole